A Study to Compare the Efficacy and Safety of BMS-986489 (BMS-986012+ Nivolumab Fixed Dose Combination) in Combination With Carboplatin Plus Etoposide to That of Atezolizumab With Carboplatin Plus Etoposide as First-Line Therapy in Participants With Extensive-Stage Small Cell Lung Cancer (TIGOS).

PHASE3RecruitingINTERVENTIONAL
Enrollment

530

Participants

Timeline

Start Date

February 25, 2025

Primary Completion Date

April 6, 2028

Study Completion Date

September 5, 2031

Conditions
Extensive-Stage Small Cell Lung Cancer
Interventions
BIOLOGICAL

BMS-986489 (BMS-986012+Nivolumab)

Specified dose on specified days

BIOLOGICAL

Atezolizumab

Specified dose on specified days

DRUG

Carboplatin

Specified dose on specified days

DRUG

Etoposide

Specified dose on specified days

Trial Locations (182)

0

RECRUITING

Orlandi Oncologia, Santiago

1200

RECRUITING

Cliniques universitaires Saint-Luc, Brussels

2560

RECRUITING

GenesisCare - Campbelltown, Campbelltown

2750

RECRUITING

Nepean Hospital, Penrith

3350

RECRUITING

Grampians Health, Ballarat Central

4000

RECRUITING

Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman, Liège

4021

RECRUITING

Kepler Universitätsklinikum, Linz

4120

RECRUITING

Gallipoli Medical Research Ltd, Brisbane

4600

RECRUITING

Klinikum Wels-Grieskirchen GmbH, Wels

6150

RECRUITING

St. John of God Murdoch Hospital, Murdoch

6830

RECRUITING

Landeskrankenhaus Rankweil, Rankweil

7000

RECRUITING

Kantonsspital Graubünden, Chur

8036

RECRUITING

Medizinische Universität Graz, Graz

8091

RECRUITING

UniversitätsSpital Zürich, Zurich

8401

RECRUITING

Kantonsspital Winterthur, Winterthur

9000

RECRUITING

UZ Gent, Ghent

13620

RECRUITING

Seoul National University Bundang Hospital, Seongnam

13915

RECRUITING

Assistance Publique Hôpitaux de Marseille - Hôpital Nord, Marseille

14059

RECRUITING

Fakultni Thomayerova nemocnice, Prague

15706

RECRUITING

CHUS - Hospital Clinico Universitario, Santiago de Compostela

16499

RECRUITING

Ajou University Hospital, Suwon

20133

RECRUITING

Fondazione IRCCS Istituto Nazionale dei Tumori, Milan

20141

RECRUITING

Istituto Europeo di Oncologia IRCCS, Milan

22927

RECRUITING

LungenClinic Grosshansdorf, Großhansdorf

23007

RECRUITING

Hospital Universitario de Jaen, Jaén

24014

RECRUITING

Oncology & Hematology Associates of Southwest Virginia, Inc., Roanoke

26121

RECRUITING

Pius Hospital Oldenburg, Oldenburg

27710

RECRUITING

Duke Cancer Institute, Durham

28034

RECRUITING

Hospital Universitario Ramón y Cajal, Madrid

28041

RECRUITING

Hospital Universitario 12 de Octubre, Madrid

28222

RECRUITING

Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda

28644

RECRUITING

Chungbuk National University Hospital, Cheongju-si

29000

RECRUITING

Centre Hospitalier de Cornouaille Quimper - Concarneau, Quimper

30060

RECRUITING

Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital, Marietta

32763

RECRUITING

Mid Florida Hematology and Oncology Center, Orange City

33705

RECRUITING

Florida Cancer Specialists - North, St. Petersburg

33901

RECRUITING

Florida Cancer Specialists - South, Fort Myers

34090

RECRUITING

Hôpital Arnaud de Villeneuve - CHU Montpellier, Montpellier

34732

RECRUITING

Istanbul Medeniyet University, Istanbul

35620

RECRUITING

T.C. Saglik Bakanligi - Izmir Il Saglik Mudurlugu Cigli Bolge Egitim Hastanesi, Çiğli

36526

RECRUITING

Southern Cancer Center, PC, Daphne

37019

RECRUITING

Casa di Cura Dott. Pederzoli, Peschiera del Garda

37203

RECRUITING

SCRI Oncology Partners, Nashville

38700

RECRUITING

Chu Grenoble Alpes, La Tronche

40138

RECRUITING

IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola, Bologna

41009

RECRUITING

Hospital Universitario Virgen Macarena, Seville

41013

RECRUITING

Hospital Universitario Virgen Del Rocio, Seville

41110

RECRUITING

University General Hospital of Larissa, Larissa

42601

RECRUITING

Keimyung University Dongsan Hospital, Daegu

44630

NOT_YET_RECRUITING

Local Institution - 0146, Guadalajara

45242

RECRUITING

Oncology Hematology Care, Cincinnati

46014

RECRUITING

Hospital General Universitario de Valencia, Valencia

50586

RECRUITING

Hospital Kuala Lumpur, Kuala Lumpur

50603

RECRUITING

University Malaya Medical Centre, Kuala Lumpur

51109

RECRUITING

Klinikum Köln-Merheim, Cologne

55407

WITHDRAWN

Local Institution - 0037, Minneapolis

57104

RECRUITING

Sanford Cancer Center, Sioux Falls

59037

RECRUITING

CHU Lille - Institut Coeur Poumon, Lille

60488

RECRUITING

Krankenhaus Nordwest GmbH, Frankfurt am Main

61615

RECRUITING

Illinois Cancer Care, Peoria

66460

NOT_YET_RECRUITING

Local Institution - 0147, Monterrey

69126

RECRUITING

Thoraxklinik-Heidelberg gGmbH, Heidelberg

69310

RECRUITING

Centre Hospitalier Lyon Sud, Pierre-Bénite

69400

RECRUITING

L Hopital Nord Ouest, Gleizé

70736

RECRUITING

Robert Bosch Krankenhaus GmbH, Stuttgart

71913

COMPLETED

Local Institution - 0283, Hot Springs

72424

NOT_YET_RECRUITING

Local Institution - 0145, Puebla City

75248

RECRUITING

Institut Curie, Paris

75702

RECRUITING

Texas Oncology - Northeast Texas, Tyler

78705

RECRUITING

Texas Oncology - Central/South Texas, Austin

80131

RECRUITING

Istituto Nazionale Tumori IRCCS Fondazione Pascale, Napoli

82131

RECRUITING

Asklepios Klinik Gauting GmbH, Gauting

85796

RECRUITING

Centrum Onkologii im. Prof. Franciszka Lukaszczyka, Bydgoszcz

87106

RECRUITING

University of New Mexico Comprehensive Cancer Center, Albuquerque

93586

RECRUITING

Sarawak General Hospital, Kuching

94010

RECRUITING

Centre Hospitalier Intercommunal de Créteil, Créteil

94800

RECRUITING

Gustave Roussy, Villejuif

98026

RECRUITING

Swedish Cancer Institute - Edmonds, Edmonds

98104

RECRUITING

Swedish Medical Center, Seattle

99437

RECRUITING

Zentralklinik Bad Berka, Bad Berka

100142

RECRUITING

Beijing Cancer hospital, Beijing

101149

RECRUITING

Beijing Chest Hospital,Capital Medical University, Beijing

110029

NOT_YET_RECRUITING

Local Institution - 0278, New Delhi

110042

NOT_YET_RECRUITING

Local Institution - 0235, Shenyang

132000

RECRUITING

Jilin Province Tumor Hospital, Changchun

150081

RECRUITING

Harbin Medical University Cancer Hospital, Harbin

200030

RECRUITING

Shanghai Chest Hospital, Shanghai

200032

RECRUITING

Zhongshan Hospital,Fudan University, Shanghai

200120

RECRUITING

Shanghai East Hospital, Shanghai

200542

RECRUITING

"Centrul de Oncologie Sfântul Nectarie", Craiova

221005

NOT_YET_RECRUITING

Local Institution - 0277, Varanasi

250117

RECRUITING

Shandong Cancer Hospital, Jinan

300060

RECRUITING

Tianjin Medical University Cancer Institute & Hospital, Tianjin

310016

RECRUITING

Sir Run Run Shaw Hospital of Zhejiang University School of Medicine, Hangzhou

310022

RECRUITING

Zhejiang Cancer Hospital, Hangzhou

317000

RECRUITING

Taizhou Hospital of Zhejiang Province, Linhai

330006

RECRUITING

The First Affiliated Hospital of Nanchang University, Nanchang

350014

RECRUITING

Fujian Cancer Hospital, Fuzhou

361003

RECRUITING

The First Affiliated hospital of Xiamen University, Xiamen

400015

RECRUITING

Institutul Oncologic Cluj, Cluj-Napoca

400030

RECRUITING

Chongqing University Cancer Hospital, Chongqing

407280

RECRUITING

SC Radiotherapy Center Cluj SRL, Florești

410013

NOT_YET_RECRUITING

Local Institution - 0216, Changsha

430079

RECRUITING

Hubei Cancer Hospital, Wuhan

430100

RECRUITING

Tongji Hospital Tongji Medical,Science & Technology, Wuhan

515000

RECRUITING

Cancer Hospital of Shantou University Medical College, Shantou

560017

NOT_YET_RECRUITING

Local Institution - 0274, Bengaluru

610041

RECRUITING

Sichuan Cancer hospital, Chengdu

625107

NOT_YET_RECRUITING

Local Institution - 0271, Madurai

700094

NOT_YET_RECRUITING

Local Institution - 0273, Kolkata

700106

RECRUITING

S.C. Centrul de Oncologie Euroclinic S.R.L., Iași

700483

RECRUITING

Institutul Regional de Oncologie, Iași

710126

RECRUITING

Xi'an International Medical Center Hospital, Xi'an

1138603

RECRUITING

Nippon Medical School Hospital, Bunkyo-ku

2520598

RECRUITING

Oncocentro Apys, Viña del Mar

7500921

RECRUITING

Fundacion Arturo Lopez Perez (FALP), Santiago

8330032

RECRUITING

Pontificia Universidad Catolica de Chile, Santiago

8420383

RECRUITING

Bradfordhill, Santiago

9810914

RECRUITING

Sendai Kousei Hospital, Sendai

14784400

RECRUITING

Fundação Pio XII - Hospital de Câncer de Barretos, Barretos

C1426ANZ

RECRUITING

Instituto Alexander Fleming, Ciudad Autónoma de Buenos Aires

C1199ABB

RECRUITING

Hospital Italiano de Buenos Aires, ABB

C1417DTB

WITHDRAWN

Local Institution - 0100, Buenos Aires

C1430EGF

RECRUITING

Clinica Adventista Belgrano, CABA

X5800AEV

RECRUITING

Instituto Médico Río Cuarto, Río Cuarto

B-9100

RECRUITING

VITAZ, Sint-Niklaas

60135-237

RECRUITING

Hospital São Carlos, Fortaleza

90035-903

RECRUITING

Hospital de Clinicas de Porto Alegre, Porto Alegre

90610-000

RECRUITING

Hospital São Lucas da PUCRS, Porto Alegre

96830-180

RECRUITING

Instituto de Oncologia Saint Gallen, Santa Cruz do Sul

88301-220

RECRUITING

Clínica de Neoplasias Litoral, Itajaí

01509-010

RECRUITING

A. C. Camargo Cancer Center, São Paulo

T6G 1Z2

RECRUITING

Cross Cancer Institute, Edmonton

G7H 5H6

RECRUITING

CIUSSS- saguenay-Lac-Saint-Jean, Chicoutimi

G1V 4G5

RECRUITING

IUCPQ, Québec

G5L 5T1

RECRUITING

Centre intégré de santé et de services sociaux du Bas Saint-Laurent- Hôpital régional de Rimouski, Rimouski

656 53

RECRUITING

Masarykuv onkologicky ustav, Brno

703 00

RECRUITING

Nemocnice AGEL Ostrava - Vitkovice a.s., Ostrava

779 00

RECRUITING

Fakultni nemocnice Olomouc, Olomouc

06120

RECRUITING

Krankenhaus Martha-Maria Halle-Dölau, Halle

115 26

RECRUITING

Errikos Dunant Hospital Center, Athens

115 27

RECRUITING

"Thoracic General Hospital of Athens I Sotiria", Athens

540 07

RECRUITING

"Theagenio Cancer Hospital of Thessaloniki", Thessaloniki

570 01

RECRUITING

European Interbalkan Medical Center, Thessaloniki

00144

RECRUITING

Istituto Nazionale Tumori Regina Elena, Rome

06132

RECRUITING

AO Santa Maria della Misericordia, Perugia

791-0280

RECRUITING

National Hospital Organization Shikoku Cancer Center, Matsuyama

830-0011

RECRUITING

Kurume University Hospital, Kurume

0608648

RECRUITING

Hokkaido University Hospital, Sapporo

650-0047

RECRUITING

Kobe City Medical Center General Hospital, Kobe

920-8641

RECRUITING

Kanazawa University Hospital, Kanazawa

236-0051

RECRUITING

Kanagawa Cardiovascular and Respiratory Center, Yokohama

634-8522

RECRUITING

Nara Medical University Hospital, Kashihara

710-8602

RECRUITING

Kurashiki Central Hospital, Kurashiki

573-1191

RECRUITING

Kansai Medical University Hospital, Hirakata

589-8511

RECRUITING

Kindai University Hospital- Osakasayama Campus, Ōsaka-sayama

569-8686

RECRUITING

Osaka Medical and Pharmaceutical University Hospital, Takatsuki

350-1298

RECRUITING

Saitama Medical University International Medical Center, Hidaka

362-0806

RECRUITING

Saitama Prefectural Cancer Center, Ina-machi

431-3192

RECRUITING

Hamamatsu University Hospital, Hamamatsu

135-8550

RECRUITING

The Cancer Institute Hospital of JFCR, Koto

960-1295

RECRUITING

Fukushima Medical University, Fukushima

1081 HV

RECRUITING

Amsterdam UMC, locatie VUmc, Amsterdam

6815 AD

RECRUITING

Ziekenhuis Rijnstate, Arnhem

9713 GZ

RECRUITING

University Medical Center Groningen, Groningen

62-500

RECRUITING

Przychodnia Lekarska KOMED, Konin

60-192

RECRUITING

Pratia Poznań, Poznan

82-550

RECRUITING

Szpital Specjalistyczny w Prabutach Spolka z o.o., Prabuty

93-338

RECRUITING

Instytut Centrum Zdrowia Matki Polki, Lodz

013812

RECRUITING

SC Memorial Healthcare International SRL, Bucharest

022328

RECRUITING

Institutul Oncologic Bucuresti, Bucharest

03722

RECRUITING

Severance Hospital, Yonsei University Health System, Seoul

05505

RECRUITING

Asan Medical Center, Seoul

08036

RECRUITING

Hospital Clínic de Barcelona, Barcelona

08041

RECRUITING

Hospital de la Santa Creu i Sant Pau, Barcelona

01370

NOT_YET_RECRUITING

Local Institution - 0154, Adana

06010

RECRUITING

Gulhane Egitim Arastirma Hastanesi, Ankara

06280

RECRUITING

Atatürk Göğüs Hastalıkları Ve Göğüs Cerrahisi Eğitim Araştırma Hastanesi, Ankara

TS4 3BW

RECRUITING

James Cook University Hospital, Central Middlesbrough

AB9 2ZB

RECRUITING

Aberdeen Royal Infirmary, Aberdeen

M20 4BX

RECRUITING

The Christie NHS Foundation Trust, Manchester

CH63 4JY

RECRUITING

The Clatterbridge Cancer Centre, Metropolitan Borough of Wirral

Sponsors
All Listed Sponsors
lead

Bristol-Myers Squibb

INDUSTRY

NCT06646276 - A Study to Compare the Efficacy and Safety of BMS-986489 (BMS-986012+ Nivolumab Fixed Dose Combination) in Combination With Carboplatin Plus Etoposide to That of Atezolizumab With Carboplatin Plus Etoposide as First-Line Therapy in Participants With Extensive-Stage Small Cell Lung Cancer (TIGOS). | Biotech Hunter | Biotech Hunter