180
Participants
Start Date
February 5, 2025
Primary Completion Date
December 31, 2027
Study Completion Date
April 1, 2028
Ketone ester
"Ketone ester (KE) (Chemical name: Bis-octanoyl-(R)-1,3-butanediol, Common name: C8 ketone di-ester) formulated as a dietary supplement.~KE 12.5 g per day for 1 week; followed by KE 25 g per day for 1 week; followed by KE 37.5 g per day split into two doses for 1 week; followed by KE 50 g per day split into two doses for 17 weeks"
Placebo Comparator: Non-ketone placebo
Placebo oil (non-ketogenic canola oil) formulated as a dietary supplement. Placebo oil 12.5 g per day for 1 week; followed by Placebo oil 25 g per day for 1 week; followed by Placebo oil 37.5 g per day split into two doses for 1 week; followed by Placebo oil 50 g per day split into two doses for 17 weeks
NOT_YET_RECRUITING
Ohio State University, Columbus
RECRUITING
Buck Institute for Research on Aging, Novato
NOT_YET_RECRUITING
UConn Health, Farmington
Lead Sponsor
Collaborators (1)
Ohio State University
OTHER
University of Connecticut
OTHER
California Pacific Medical Center Research Institute
OTHER
Buck Institute for Research on Aging
OTHER