Targeting Aging With a Ketone Ester for Function in Frailty

NARecruitingINTERVENTIONAL
Enrollment

180

Participants

Timeline

Start Date

February 5, 2025

Primary Completion Date

December 31, 2027

Study Completion Date

April 1, 2028

Conditions
Frail ElderlyAgingImmune FunctionMuscle Function
Interventions
OTHER

Ketone ester

"Ketone ester (KE) (Chemical name: Bis-octanoyl-(R)-1,3-butanediol, Common name: C8 ketone di-ester) formulated as a dietary supplement.~KE 12.5 g per day for 1 week; followed by KE 25 g per day for 1 week; followed by KE 37.5 g per day split into two doses for 1 week; followed by KE 50 g per day split into two doses for 17 weeks"

OTHER

Placebo Comparator: Non-ketone placebo

Placebo oil (non-ketogenic canola oil) formulated as a dietary supplement. Placebo oil 12.5 g per day for 1 week; followed by Placebo oil 25 g per day for 1 week; followed by Placebo oil 37.5 g per day split into two doses for 1 week; followed by Placebo oil 50 g per day split into two doses for 17 weeks

Trial Locations (3)

43210

NOT_YET_RECRUITING

Ohio State University, Columbus

94945

RECRUITING

Buck Institute for Research on Aging, Novato

06030

NOT_YET_RECRUITING

UConn Health, Farmington

All Listed Sponsors
collaborator

Ohio State University

OTHER

collaborator

University of Connecticut

OTHER

collaborator

California Pacific Medical Center Research Institute

OTHER

lead

Buck Institute for Research on Aging

OTHER