Targeting Repetitive Behaviors in Autism Spectrum Disorder Via Transcranial Direct Current Stimulation

NARecruitingINTERVENTIONAL
Enrollment

78

Participants

Timeline

Start Date

October 3, 2024

Primary Completion Date

January 31, 2026

Study Completion Date

April 30, 2026

Conditions
Autism Spectrum Disorder
Interventions
DEVICE

Active HD-tDCS over pre-SMA

Active cathodal HD-tDCS over pre-SMA cortex will be delivered for 10 days (3 sessions per week). The 4 × 1 montage using small circular electrodes (diameter 1 cm) will be applied with the cathode placed centrally over Fz. The current intensity will be set at 0.5 mA for a total of 20 minutes (30 s ramp up/down).

DEVICE

Active HD-tDCS over left DLPFC

Active cathodal HD-tDCS over left DLPFC cortex will be delivered for 10 days (3 sessions per week). The 4 × 1 montage using small circular electrodes (diameter 1 cm) will be applied with the cathode placed centrally over F3. The current intensity will be set at 0.5 mA for a total of 20 minutes (30 s ramp up/down).

DEVICE

Sham HD-tDCS

Sham HD-tDCS will be delivered over pre-SMA or left-dlPFC cortex for 10 days (3 sessions per week). The same electrodes placement as well as the stimulation set-up will be used as in the active stimulation conditions, but the current will be applied for 30 s and will be ramped down (0 mA) during the rest of the session without the participants awareness. Each Sham session will last 20 minutes.

Trial Locations (1)

00152

RECRUITING

Bambino Gesù Children Hospital, Rome

All Listed Sponsors
collaborator

Ministero della Salute, Italy

OTHER

lead

Bambino Gesù Hospital and Research Institute

OTHER