Progesterone-modified Natural Cycle for FET

PHASE3Not yet recruitingINTERVENTIONAL
Enrollment

336

Participants

Timeline

Start Date

December 5, 2024

Primary Completion Date

September 10, 2026

Study Completion Date

December 1, 2027

Conditions
Infertility, Female
Interventions
DRUG

Progesterone-modified natural cycle preparation for frozen embryo transfer

A novel endometrial preparation protocol that optimizes the natural cycle, whereby as long as the thickness of the endometrium is suitable for embryo transfer, vaginal progesterone can be used to transform the endometrium before ovulation and subsequently FET.

DRUG

Hormone replacement therapy cycle preparation for frozen embryo transfer

A traditional endometrial preparation protocol is used for FET, which involves using fixed or flexible exogenous estradiol for artificial cycles. This protocol typically involves starting exogenous estradiol on day 3 or 4 of the cycle, continuing for 7-10 days, and then discontinuing. Upon determining that the endometrial thickness meets the standard, progesterone conversion of the endometrium can be performed.

All Listed Sponsors
lead

Shandong University of Traditional Chinese Medicine

OTHER