NCT06639061View on ClinicalTrials.gov

Neuromodulation of the Hippocampus to Reduce Intrusive Re-Experiencing in PTSD: A Randomized Controlled Trial

PHASE2RecruitingINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

November 1, 2024

Primary Completion Date

October 31, 2027

Study Completion Date

November 30, 2028

Conditions
PTSD - Post Traumatic Stress DisorderIntrusive Memories of Traumatic Event(s)
Interventions
DEVICE

Hippocampal stimulation using repetitive transcranial magnetic stimulation (rTMS)

"We will use fMRI resting state data to personalize a TMS inhibitory stimulation to a cortical location that is the most strongly connected to a deeper left hippocampal target.~5 once a week sessions of rTMS will be delivered at 1-Hz stimulation frequency for 15 minutes following trauma memory reactivation."

DEVICE

Sham stimulation using repetitive transcranial magnetic stimulation (rTMS)

We will use fMRI resting state data to personalize a TMS sham stimulation to a cortical location with near zero connectivity to a deeper left hippocampal target. 5 once a week sessions of rTMS will be delivered at 1-Hz stimulation frequency for 15 minutes following trauma memory reactivation.

Trial Locations (1)

Unknown

RECRUITING

Tel Aviv University, Tel Aviv

All Listed Sponsors
lead

Tel Aviv University

OTHER