Daptomycin vs. Vancomycin for the Treatment of Methicillin Resistant S. Aureus Bacteremia

PHASE4RecruitingINTERVENTIONAL
Enrollment

300

Participants

Timeline

Start Date

November 14, 2024

Primary Completion Date

January 31, 2027

Study Completion Date

November 30, 2027

Conditions
Staphylococcus Aureus SepticemiaStaphylococcus Aureus BacteremiaS. Aureus BacteremiaS. Aureus Bloodstream InfectionStaphylococcus Aureus Endocarditis
Interventions
DRUG

Daptomycin for Injection

Daptomycin given by injection at a dose determined by the treating team but not to be less than 6mg/kg

DRUG

Vancomycin (IV)

Vancomycin by injection to be given at a dose selected by the treating team to achieve a desired trough level or AUC-based target, as determined by local standards of care

Trial Locations (13)

2139

RECRUITING

Concord Repatriation and General Hospital, Concord

2145

RECRUITING

Westmead Hospital, Westmead

2305

NOT_YET_RECRUITING

John Hunter Hospital, Newcastle

3050

RECRUITING

Royal Melbourne Hospital, Parkville

3128

RECRUITING

Box Hill Hospital, Box Hill

3168

RECRUITING

Monash Medical Campus (Monash Medical Centre + Jesse McPherson Private Hospital), Clayton

4029

RECRUITING

Royal Brisbane and Women's Hospital, Herston

5042

NOT_YET_RECRUITING

Flinders Medical Centre, Bedford Park

6000

NOT_YET_RECRUITING

Royal Perth Hospital, Perth

6150

NOT_YET_RECRUITING

Fiona Stanley Hospital, Murdoch

V3V1Z2

RECRUITING

Fraser Health Authority (Surrey Memorial Hospital), Surrey

Unknown

RECRUITING

Newfoundland Health Services (Health Sciences Centre and St. Clare's Mercy Hospital), St. John's

H4A3S1

RECRUITING

McGill University Health Centre (Royal Victoria Hospital and Montreal General Hospital), Montreal

All Listed Sponsors
collaborator

University of Melbourne

OTHER

collaborator

The Peter Doherty Institute for Infection and Immunity

OTHER

lead

Todd C. Lee MD MPH FIDSA

OTHER

NCT06637332 - Daptomycin vs. Vancomycin for the Treatment of Methicillin Resistant S. Aureus Bacteremia | Biotech Hunter | Biotech Hunter