Probiotics in the Prevention of Recurrent Prosthetic Joint Infection of the Hip and Knee

PHASE4Enrolling by invitationINTERVENTIONAL
Enrollment

152

Participants

Timeline

Start Date

August 15, 2025

Primary Completion Date

June 30, 2027

Study Completion Date

June 30, 2027

Conditions
Prosthetic-joint InfectionDysbiosis
Interventions
DRUG

Probiotic

Culturelle probiotic, one capsule daily to start following SOC surgical treatment for PJI during the initial 6 weeks of SOC antibiotic treatment.

OTHER

Standard of care

Standard of care (SOC) treatment includes surgery and antimicrobials.

Trial Locations (2)

10016

New York University Langone Orthopedics, New York

02118

Boston Medical Center, Orthopedic Surgery, Boston

Sponsors
All Listed Sponsors
collaborator

American Association of Hip and Knee Surgeons

OTHER

lead

Boston Medical Center

OTHER