Optimized Posterior Left Atrial Wall Ablation Strategy for PeAF

NANot yet recruitingINTERVENTIONAL
Enrollment

384

Participants

Timeline

Start Date

October 1, 2024

Primary Completion Date

September 1, 2025

Study Completion Date

January 1, 2026

Conditions
Persistent Atrial Fibrillation
Interventions
PROCEDURE

PVI + Posterior Wall Isolation (PWI) + Electrogram Ablation (EGM)

PVI + Posterior Wall Isolation (PWI) + Electrogram Ablation (EGM) After performing PVI, electrogram mapping of the posterior left atrial wall is conducted. Subsequently, PWI and EGM ablation are performed. In this group, multipolar mapping catheters are used for EGM mapping. Target EGMs include spatially discrete potentials (STPs), localized short cycle length potentials (SCLPs), and focal activities.

PROCEDURE

PVI + Posterior Wall Isolation (PWI)

After performing PVI, the mapping catheter will be placed on the posterior wall to assess electrical activity and guide ablation. A bottom linear ablation (25-40W) will be performed, connecting the lowest points beneath the lower PVs. A top linear ablation (25-40W) will be conducted at the top of the left atrium, connecting the highest points above the upper PVs. If posterior wall isolation is not achieved after completing the bottom and top lines, mapping and localization of the earliest activation point within the box will be performed during pacing from the coronary sinus (CS). Posterior wall isolation will be completed by identifying and ablating local potentials at the entry and exit sites.

PROCEDURE

Pulmonary Vein Isolation (PVI) alone

The distance between the ablation lines on the posterior wall after circumferential pulmonary vein isolation should be at least 2 centimeters to limit the portion of the posterior wall within the PVI ablation zone. PVI will be confirmed by verifying entrance and exit block at the PV orifices.

All Listed Sponsors
collaborator

Tongji Hospital affiliated to Tongji University

UNKNOWN

collaborator

Shanghai 10th People's Hospital

UNKNOWN

collaborator

Shanghai Sixth People's Hospital affiliated to Shanghai Jiao Tong University School Of Medicine

UNKNOWN

lead

Shanghai Chest Hospital

OTHER

NCT06633523 - Optimized Posterior Left Atrial Wall Ablation Strategy for PeAF | Biotech Hunter | Biotech Hunter