Phase 3 Study of Daraxonrasib (RMC-6236) in Patients With Previously Treated Metastatic Pancreatic Ductal Adenocarcinoma (PDAC)

PHASE3RecruitingINTERVENTIONAL
Enrollment

460

Participants

Timeline

Start Date

October 16, 2024

Primary Completion Date

June 30, 2026

Study Completion Date

December 31, 2027

Conditions
Pancreatic CancerPDACPDAC - Pancreatic Ductal Adenocarcinoma
Interventions
DRUG

RMC-6236

Oral Tablets

DRUG

Gemcitabine

intravenous (IV) infusion

DRUG

nab-paclitaxel

IV infusion

DRUG

Irinotecan

IV infusion

DRUG

Liposomal irinotecan

IV infusion

DRUG

5-fluorouracil

IV infusion

DRUG

leucovorin

IV infusion

DRUG

Oxaliplatin

IV infusion

Trial Locations (60)

10016

ACTIVE_NOT_RECRUITING

NYU Lagone Health, New York

10022

ACTIVE_NOT_RECRUITING

Memorial Sloan Kettering Cancer Center, New York

10032

ACTIVE_NOT_RECRUITING

Columbia University Medical Center, New York

13009

ACTIVE_NOT_RECRUITING

Institut Paoli Calmettes, Marseille

13353

RECRUITING

Charité Universitätsmedizin, Campus Berlin Mitte, Berlin

14263

ACTIVE_NOT_RECRUITING

Roswell Park Cancer Institute, Buffalo

15232

ACTIVE_NOT_RECRUITING

UPMC Hillman Cancer Center, Pittsburgh

19104

ACTIVE_NOT_RECRUITING

Abramson Cancer Center Clinical Research Unit, Philadelphia

21287

ACTIVE_NOT_RECRUITING

Johns Hopkins, Baltimore

22031

ACTIVE_NOT_RECRUITING

Virginia Cancer Specialists, Fairfax

27710

ACTIVE_NOT_RECRUITING

Duke University Medical Center, Durham

28041

ACTIVE_NOT_RECRUITING

Hospital 12 de Octubre, Madrid

31008

ACTIVE_NOT_RECRUITING

Clinica Universidad de Navarra, Pamplona

32224

ACTIVE_NOT_RECRUITING

Mayo Clinic Cancer Center - Florida, Jacksonville

32909

ACTIVE_NOT_RECRUITING

Cancer Care Centers of Brevard Inc, Palm Bay

33136

ACTIVE_NOT_RECRUITING

University of Miami Sylvester Comprehensive Cancer Center, Miami

33612

ACTIVE_NOT_RECRUITING

Moffitt Cancer Center, Tampa

35042

ACTIVE_NOT_RECRUITING

Centre Eugene Marquis, Rennes

35128

ACTIVE_NOT_RECRUITING

IOV-Istituto Oncologico, Padua

37203

ACTIVE_NOT_RECRUITING

Sarah Cannon Research Institute (Tennessee), Nashville

45219

ACTIVE_NOT_RECRUITING

University of Cincinnati Medical Center, Cincinnati

46010

ACTIVE_NOT_RECRUITING

Hospital Clinico de Valencia, Valencia

48109

ACTIVE_NOT_RECRUITING

University of Michigan, Ann Arbor

48201

ACTIVE_NOT_RECRUITING

Karmanos Cancer Institute, Detroit

55905

ACTIVE_NOT_RECRUITING

Mayo Clinic Cancer Center - Rochester, Rochester

56126

ACTIVE_NOT_RECRUITING

Azienda Ospedaliera, Pisa

60637

ACTIVE_NOT_RECRUITING

The University of Chicago Medical Center, Chicago

63110

ACTIVE_NOT_RECRUITING

Washington University, St Louis

69120

RECRUITING

Nationales Centrum fur, Heidelberg

73104

ACTIVE_NOT_RECRUITING

Stephenson Cancer Center, Oklahoma City

75063

ACTIVE_NOT_RECRUITING

Texas Oncology - Central South, Irving

75246

ACTIVE_NOT_RECRUITING

Texas Oncology Sammons, Dallas

77030

ACTIVE_NOT_RECRUITING

MD Anderson Cancer Center, Houston

80012

ACTIVE_NOT_RECRUITING

Rocky Mountain Cancer, Aurora

81377

RECRUITING

Universitatsklinikum Ulm, Zentru, München

84112

ACTIVE_NOT_RECRUITING

Huntsman Cancer Institute, Salt Lake City

85054

ACTIVE_NOT_RECRUITING

Mayo Clinic Cancer Center - Phoenix, Phoenix

85234

ACTIVE_NOT_RECRUITING

Banner MD Anderson Cancer Center, Gilbert

89081

RECRUITING

Universitatsklinikum Ulm, Ulm

90048

ACTIVE_NOT_RECRUITING

Cedars-Sinai Medical Center, Los Angeles

90095

ACTIVE_NOT_RECRUITING

UCLA, Los Angeles

91010

ACTIVE_NOT_RECRUITING

City of Hope-Duarte, Duarte

92037

ACTIVE_NOT_RECRUITING

UC San Diego Health Moores Cancer Center, San Diego

94158

ACTIVE_NOT_RECRUITING

Mission Hall UCSF, San Francisco

94804

ACTIVE_NOT_RECRUITING

Hopital Paul Brousse, Villejuif

94805

ACTIVE_NOT_RECRUITING

Gustave Roussy, Villejuif

96813

ACTIVE_NOT_RECRUITING

The Queen's Medical Center, Honolulu

97239

ACTIVE_NOT_RECRUITING

Oregon Health and Science University, Portland

98109

ACTIVE_NOT_RECRUITING

Fred Hutchinson Cancer Center, Seattle

4648681

RECRUITING

Aichi Cancer Center, Nagoya

02215

ACTIVE_NOT_RECRUITING

Dana Farber Cancer Institute, Boston

Unknown

ACTIVE_NOT_RECRUITING

Fondazione IRCCS Istituto Nazionale dei Tumori, Milan

ACTIVE_NOT_RECRUITING

IEO-Istituto Europeo di Oncologia, Milan

277-8577

RECRUITING

National Cancer Center, Chiba

541-8567

RECRUITING

Osaka International Cancer, Osaka

104-0045

RECRUITING

National Cancer Center Hospital, Tokyo

135-8550

RECRUITING

Cancer Institute Hospital of JFCR, Tokyo

241-8515

RECRUITING

Kanagawa Cancer Center, Yokohama

00907

ACTIVE_NOT_RECRUITING

Pan-American Center for Oncology Trials, San Juan

08035

ACTIVE_NOT_RECRUITING

Hospital Unversitari, Barcelona

All Listed Sponsors
lead

Revolution Medicines, Inc.

INDUSTRY