A Study to Compare the Efficacy and Safety of BMS-986393 Versus Standard Regimens in Adult Participants With Relapsed or Refractory and Lenalidomide-exposed Multiple Myeloma (QUINTESSENTIAL-2)

PHASE3RecruitingINTERVENTIONAL
Enrollment

440

Participants

Timeline

Start Date

March 12, 2025

Primary Completion Date

December 30, 2027

Study Completion Date

June 22, 2032

Conditions
Relapsed or Refractory Multiple Myeloma (RRMM)
Interventions
DRUG

BMS-986393

Specified dose on specified days

DRUG

Cyclophosphamide

Specified dose on specified days

DRUG

Fludarabine

Specified dose on specified days

DRUG

Daratumumab

Specified dose on specified days

DRUG

Pomalidomide

Specified dose on specified days

DRUG

Dexamethasone

Specified dose on specified days

DRUG

Carfilzomib

Specified dose on specified days

Trial Locations (125)

106

NOT_YET_RECRUITING

Local Institution - 0150, Taipei City

1097

NOT_YET_RECRUITING

Local Institution - 0125, Budapest

1140

RECRUITING

Hanusch-Krankenhaus, Vienna

1200

NOT_YET_RECRUITING

Local Institution - 0217, Brussels

2050

RECRUITING

Royal Prince Alfred Hospital, Camperdown

2100

RECRUITING

Rigshospitalet, Copenhagen

2170

NOT_YET_RECRUITING

Local Institution - 0190, Liverpool

2650

NOT_YET_RECRUITING

Local Institution - 0220, Edegem

3000

RECRUITING

Peter MacCallum Cancer Centre, Melbourne

3004

RECRUITING

The Alfred Hospital, Melbourne

3010

RECRUITING

Inselspital Bern, Bern

3168

RECRUITING

Monash Health, Clayton

4000

NOT_YET_RECRUITING

Local Institution - 0208, Roskilde

4020

RECRUITING

Ordensklinikum Linz GmbH Elisabethinen, Linz

4102

RECRUITING

Princess Alexandra Hospital, Brisbane

5000

RECRUITING

Royal Adelaide Hospital, Adelaide

RECRUITING

Odense Universitetshospital, Odense

5530

RECRUITING

Université Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant-Godinne - Site Godinne, Yvoir

6150

RECRUITING

Fiona Stanley Hospital, Murdoch

8200

RECRUITING

Aarhus Universitetshospital, Skejby, Aarhus

9000

RECRUITING

UZ Gent, Ghent

9007

RECRUITING

Cantonal Hospital St.Gallen, Sankt Gallen

10002

NOT_YET_RECRUITING

Local Institution - 0152, Taipei

10126

RECRUITING

Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Turin

11217

NOT_YET_RECRUITING

Local Institution - 0200, Taipei

12462

RECRUITING

Attikon General University Hospital, Chaïdári

12713

NOT_YET_RECRUITING

Local Institution - 0178, Riyadh

12808

RECRUITING

Vseobecna fakultni nemocnice v Praze, Prague

13353

NOT_YET_RECRUITING

Local Institution - 0213, Berlin

15706

RECRUITING

CHUS - Hospital Clinico Universitario, Santiago de Compostela

16132

NOT_YET_RECRUITING

Local Institution - 0119, Genova

18012

NOT_YET_RECRUITING

Local Institution - 0202, Granada

19111

RECRUITING

Fox Chase Cancer Center, Philadelphia

20089

RECRUITING

Istituto Clinico Humanitas, Rozzano

20133

RECRUITING

Fondazione IRCCS Istituto Nazionale dei Tumori, Milan

20246

RECRUITING

Universitaetsklinikum Hamburg-Eppendorf, Hamburg

24105

NOT_YET_RECRUITING

Local Institution - 0212, Kiel

26504

RECRUITING

University Hospital of Patras, Pátrai

27157

NOT_YET_RECRUITING

Local Institution - 0216, Winston-Salem

28204

NOT_YET_RECRUITING

Local Institution - 0067, Charlotte

30322

RECRUITING

Winship Cancer Institute, Emory University, Atlanta

30625

RECRUITING

Medizinische Hochschule Hannover, Hanover

31008

RECRUITING

Clinica Universidad de Navarra, Pamplona

33100

NOT_YET_RECRUITING

Local Institution - 0106, Udine

33136

NOT_YET_RECRUITING

Local Institution - 0130, Miami

35205

RECRUITING

University of Alabama at Birmingham, Birmingham

37007

RECRUITING

Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca, Salamanca

39120

NOT_YET_RECRUITING

Local Institution - 0211, Magdeburg

40138

RECRUITING

IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola, Bologna

44000

NOT_YET_RECRUITING

Local Institution - 0194, Nantes

44195

NOT_YET_RECRUITING

Local Institution - 0193, Cleveland

53226

NOT_YET_RECRUITING

Local Institution - 0195, Milwaukee

55455

NOT_YET_RECRUITING

Local Institution - 0219, Minneapolis

59000

RECRUITING

Hopital Claude Huriez - CHU de Lille, Lille

69310

RECRUITING

Centre Hospitalier Lyon Sud, Pierre-Bénite

71103

NOT_YET_RECRUITING

Local Institution - 0218, Shreveport

75010

NOT_YET_RECRUITING

Local Institution - 0210, Paris

81675

RECRUITING

TUM Klinikum, Munich

84112

NOT_YET_RECRUITING

Local Institution - 0044, Salt Lake City

90404

RECRUITING

UCLA Hematology/Oncology - Santa Monica, Los Angeles

90419

RECRUITING

Klinikum Nuernberg Nord, Nuremberg

94010

RECRUITING

Henri Mondor Hospital, Créteil

97080

RECRUITING

Universitaetsklinikum Wuerzburg, Würzburg

119074

NOT_YET_RECRUITING

Local Institution - 0180, Singapore

169608

NOT_YET_RECRUITING

Local Institution - 0181, Singapore

404332

NOT_YET_RECRUITING

Local Institution - 0151, Taichung

700483

RECRUITING

Institutul Regional de Oncologie, Iași

5262100

RECRUITING

Sheba Medical Center, Ramat Gan

6423906

RECRUITING

Sourasky Medical Center, Tel Aviv

9112001

RECRUITING

Hadassah Medical Center, Jerusalem

02118

NOT_YET_RECRUITING

Local Institution - 0196, Boston

C1199ABB

RECRUITING

Hospital Italiano de Buenos Aires, ABB

WITHDRAWN

Local Institution - 0214, ABB

C1118AAT

RECRUITING

Hospital Aleman, Buenos Aires

34000-000

NOT_YET_RECRUITING

Local Institution - 0012, Nova Lima

01509-010

NOT_YET_RECRUITING

Local Institution - 0013, São Paulo

04501-000

NOT_YET_RECRUITING

Local Institution - 0103, São Paulo

05652-900

NOT_YET_RECRUITING

Local Institution - 0031, São Paulo

T2N 4N2

NOT_YET_RECRUITING

Local Institution - 0069, Calgary

V5Z 1M9

RECRUITING

Vancouver General Hospital, Vancouver

B3H 2Y9

RECRUITING

QEII Health Sciences Centre - Victoria General Site, Halifax

L8V5C2

NOT_YET_RECRUITING

Local Institution - 0192, Hamilton

H1T 2M4

RECRUITING

CIUSSS de l'Est-de-l'Île-de-Montréal, Montreal

625 00

RECRUITING

Fakultní nemocnice Brno Bohunice, Brno

500 05

NOT_YET_RECRUITING

Local Institution - 0093, Hradec Králové

00029

RECRUITING

Helsinki University Hospital - Comprehensive Cancer Center (HYKS - Syöpäkeskus), Helsinki

09116

NOT_YET_RECRUITING

Local Institution - 0204, Chemnitz

04103

RECRUITING

Universitätsklinikum Leipzig, Leipzig

D-69120

RECRUITING

Universitaetsklinikum Heidelberg, Heidelberg

106 76

RECRUITING

Evangelismos General Hospital of Athens, Athens

467-8602

RECRUITING

Nagoya City University Hospital, Nagoya

277-8577

RECRUITING

National Cancer Center Hospital East, Kashiwa

663-8501

RECRUITING

Hyogo Medical University Hospital, Nishinomiya

920-8641

RECRUITING

Kanazawa University Hospital, Kanazawa

812-8582

RECRUITING

Kyushu University Hospital, Fukuoka

860-8556

RECRUITING

Kumamoto University Hospital, Kumamoto

701-1192

RECRUITING

National Hospital Organization Okayama Medical Center, Okayama

543-8555

RECRUITING

Osaka Red Cross Hospital, Osaka

150-8935

RECRUITING

Japanese Red Cross Medical Center, Tokyo

990-9585

RECRUITING

Yamagata University Hospital, Yamagata

6525 GA

RECRUITING

Radboudumc, Nijmegen

6229 HX

RECRUITING

Maastricht UMC+, Maastricht

1081 HV

NOT_YET_RECRUITING

Local Institution - 0179, Amsterdam

3584 CX

RECRUITING

Universitair Medisch Centrum Utrecht, Utrecht

0450

RECRUITING

Sykehusapoteket Ull, Oslo

20-090

RECRUITING

Centrum Onkologii Ziemi Lubelskiej, Lublin

80-214

RECRUITING

Uniwersyteckie Centrum Kliniczne, Gdansk

40-519

NOT_YET_RECRUITING

Local Institution - 0084, Katowice

93-513

RECRUITING

Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika w Lodzi, Lodz

4200-072

RECRUITING

Instituto Português de Oncologia do Porto Francisco Gentil, EPE, Porto

022328

RECRUITING

Fundeni Clinical Institute, Bucharest

03080

NOT_YET_RECRUITING

Local Institution - 0147, Seoul

05505

NOT_YET_RECRUITING

Local Institution - 0146, Seoul

06351

NOT_YET_RECRUITING

Local Institution - 0148, Seoul

06591

NOT_YET_RECRUITING

Local Institution - 0149, Seoul

07120

NOT_YET_RECRUITING

Local Institution - 0203, Palma

08916

NOT_YET_RECRUITING

Local Institution - 0201, Badalona

221 85

NOT_YET_RECRUITING

Local Institution - 0023, Lund

141 86

RECRUITING

Karolinska Universitetssjukhuset Huddinge, Huddinge

06200

NOT_YET_RECRUITING

Local Institution - 0170, Ankara

CB2 2QQ

RECRUITING

Addenbrooke's Hospital, Cambridge

NW1 2PG

RECRUITING

University College London Hospital, London

OX3 7LE

NOT_YET_RECRUITING

Local Institution - 0157, Oxford

M20 4BX

RECRUITING

The Christie NHS Foundation Trust, Manchester

NE7 7DN

RECRUITING

Freeman Hospital, Newcastle upon Tyne

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Celgene Corporation

INDUSTRY

lead

Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

INDUSTRY