Non-invasive Treatment for Long COVID (Post COVID-19 Condition) Brain Fog

NARecruitingINTERVENTIONAL
Enrollment

45

Participants

Timeline

Start Date

September 24, 2024

Primary Completion Date

October 31, 2025

Study Completion Date

December 31, 2025

Conditions
Long COVID
Interventions
OTHER

Acute Placebo Visit

The placebo visit will include 6 simulated cycles of 5 minutes breathing 21% oxygen from a douglas bag and 5 minutes breathing room air.

OTHER

Acute Progressive Carbon Dioxide

The progressive carbon dioxide visit will include a 60-minute progressive ramp which includes 6 cycles of progressive CO2 ramping starting at 0% and progressing up to 10% within 5 minutes immediately followed with 5 minutes of room air breathing in between cycles.

OTHER

Acute Intermittent Hypoxia

The intermittent hypoxia exposure visit will include 6 cycles breathing 8-12% oxygen (O2) for 5 minutes with a target pulse oximeter saturation of 86-90%, followed by 5 minutes of breathing room air.

OTHER

Training: Progressive Carbon Dioxide Ramping

Intervention will consist of 6 to 10 study visits (3-5 sessions/week) to be completed within 14 days. Subjects will will be given the progressive CO2 ramp protocol of 60-minute sessions, which will include 6 cycles of progressive CO2 ramping starting at 0% and progressing up to 10% within 5 minutes immediately followed with 5 minutes of room air breathing in between cycles, for every visit during the 14 days.

OTHER

Training: Intermittent Hypoxic Exposure

Intervention will consist of 6 to 10 study visits (3-5 sessions/week) to be completed within 14 days. Subjects will will be given the intermittent hypoxia exposure protocol of 60-minute sessions, which will include 6 cycles breathing 8-12% oxygen (O2) for 5 minutes with a target pulse oximeter saturation of 86-90%, followed by 5 minutes of breathing room air for every visit during the 14 days.

OTHER

Training: Placebo Control

Intervention will consist of 6 to 10 study visits (3-5 sessions/week) to be completed within 14 days. Subjects will complete 6 simulated cycles of 5 minutes breathing 21% oxygen from a douglas bag and 5 minutes breathing room air (60 minutes) for every visit during the 14 days.

Trial Locations (1)

85259

RECRUITING

Mayo Clinic in Arizona, Scottsdale

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Mayo Clinic

OTHER

NCT06614309 - Non-invasive Treatment for Long COVID (Post COVID-19 Condition) Brain Fog | Biotech Hunter | Biotech Hunter