75
Participants
Start Date
December 12, 2017
Primary Completion Date
March 31, 2020
Study Completion Date
March 31, 2020
intravenous rescue opioid analgesia using fentanyl
intraoperative rescue opioid analgesia using 1mcg/kg of fentanyl (Fentanyl WZF, POlfa Warsawa, Poland) )/ body weight when SPI value \> 15 baseline
intravenous rescue atropine administration
atropine (Atropinum Sulfuricum WZF, POlfa Warsawa, Poland) in a dose of 0,5mg/kg of will be administered intravenously when heart rate \< 50
intravenous rescue urapidil administration
urapidil (Ebrantil 25, Takeda PHARMA, Japan) in a dose of 10 mg will be administered intravenously when DAP \> 110 mmHg or SAP \> 200 mmHg
intravenous rescue ephedrine administration
ephedrine (Ephedrinum Sulfuricum WZF, POlfa Warsawa, Poland) in a dose of 10 mg will be administered intravenously when DAP \< 50 mmHg or MAP \< 65 mmHg
concentrate of red blood cells
concentrate of red blood cells will be transfused when concentration of haemoglobin \< 10g%
red blood cells autotransfusion
red blood cells from the operation site will be retransfused using cell saver
primary treatment of postoperative nausea and vomiting (PONV)
dexamethasone ((Dexaven 4mg/ml, Jelfa, Poland) in a dose of 4 mg will be administered intravenously when incidence of PONV is observed
secondary treatment of postoperative nausea and vomiting (PONV)
Ondansetron (Ondansetron Accord 2mg/ml, 2 ml solution, Accord Healthcare Limited, Great Britain) in a dose of 4 mg will be administered intravenously when incidence of persistent PONV is observed despite the dexamethasone in a dose of 4 mg will be administration intravenously
intraopertative fluid challenge (IFC)
3 mililitre of synthetic colloid will be transfused intravenously per each sudden blood loss of 1 mililitre
postoperative rescue opioid analgesia using morphine
postoperative rescue opioid analgesia will be administered intravenously using 2 miligrams of morphine ((Morfini Sulfas WZF, 20mg/ml, solutio pro iniectione, Polfa Warszawa, Poland)every 10 minutes until postoperative pain perception using NPRS scale will decrease below 4 (NPRS; 0 meant no pain and 10 meant the worst pain imaginable)
Medical University of Silesia, Sosnowiec
Silesian University of Medicine
OTHER
Michał Stasiowski
OTHER