A Study of the Pan-KRAS Inhibitor LY4066434 in Participants With KRAS Mutant Solid Tumors

PHASE1RecruitingINTERVENTIONAL
Enrollment

750

Participants

Timeline

Start Date

October 21, 2024

Primary Completion Date

January 31, 2030

Study Completion Date

January 31, 2030

Conditions
Pancreatic Ductal AdenocarcinomaNon-small Cell Lung CancerColorectal CancerAdvanced Solid TumorMetastatic Solid Tumor
Interventions
DRUG

LY4066434.

Administered orally.

DRUG

Cetuximab

Administered intravenously.

DRUG

Nab paclitaxel

Administered intravenously.

DRUG

Gemcitabine

Administered intravenously.

DRUG

Oxaliplatin

Administered intravenously.

DRUG

Leucovorin

Administered intravenously.

DRUG

Irinotecan

Administered intravenously.

DRUG

5Fluorouracil

Administered intravenously.

DRUG

Carboplatin

Administered intravenously.

DRUG

Cisplatin

Administered intravenously.

DRUG

Pemetrexed

Administered intravenously.

DRUG

Pembrolizumab

Administered intravenously.

Trial Locations (56)

1070

RECRUITING

Universite Libre de Bruxelles (ULB) - Institut Jules Bordet, Brussels

1200

RECRUITING

Cliniques universitaires Saint-Luc, Brussels

9000

RECRUITING

UZ Gent, Ghent

10016

RECRUITING

National Taiwan University Hospital, Taipei

10032

RECRUITING

Columbia University, New York

10065

RECRUITING

David H. Koch Center for Cancer Care at Memorial Sloan Kettering Cancer Center, New York

10117

NOT_YET_RECRUITING

Charite Universitaetsmedizin Berlin, Berlin

15213

RECRUITING

University of Pittsburgh Medical Center, Pittsburgh

22031

RECRUITING

Virginia Cancer Specialists, Fairfax

22763

RECRUITING

Asklepios Kliniken Hamburg GmbH - Asklepios Klinik Altona, Hamburg

27710

RECRUITING

Duke University Medical Center, Durham

28007

NOT_YET_RECRUITING

Hospital General Universitario Gregorio Maranon, Madrid

28034

RECRUITING

Hospital Universitario Ramon y Cajal, Madrid

28041

RECRUITING

Hospital Universitario 12 de Octubre, Madrid

29010

RECRUITING

Hospital Regional Universitario de Malaga, Málaga

35233

RECRUITING

University of Alabama at Birmingham, Birmingham

37134

RECRUITING

Centro Ricerche Cliniche di Verona s.r.l., Verona

37203

RECRUITING

Sarah Cannon Research Institute/SCRI, Nashville

RECRUITING

SCRI Oncology Partners, Nashville

44195

RECRUITING

Cleveland Clinic, Cleveland

46202

RECRUITING

Indiana University (IU), Indianapolis

48202

RECRUITING

Henry Ford Health System, Detroit

49546

RECRUITING

South Texas Accelerated Research Therapeutics (START) Midwest, Grand Rapids

55905

NOT_YET_RECRUITING

Mayo Clinic - Rochester, Rochester

60488

RECRUITING

Krankenhaus Nordwest GmbH, Frankfurt

60637

NOT_YET_RECRUITING

The University of Chicago Medical Center (UCMC), Chicago

69008

NOT_YET_RECRUITING

Centre Leon Berard, Lyon

73104

NOT_YET_RECRUITING

University of Oklahoma - Health Sciences Center, Oklahoma City

74078

RECRUITING

SLK-Kliniken Heilbronn GmBH, Heilbronn

75244

RECRUITING

University of Texas Southwestern, Dallas

77030

RECRUITING

MD Anderson Cancer Center, Houston

78229

RECRUITING

South Texas Accelerated Research Therapeutics (START), San Antonio

80220

NOT_YET_RECRUITING

University of Colorado Denver, Denver

85054

RECRUITING

Mayo Clinic, Phoenix

90025

RECRUITING

University of California, Los Angeles (UCLA), Los Angeles

91010

RECRUITING

City of Hope, Duarte

94805

NOT_YET_RECRUITING

Institut Gustave Roussy, Villejuif

97080

RECRUITING

Universitaetsklinikum Wuerzburg, Würzburg

98104

RECRUITING

Swedish Cancer Institute (SCI), Seattle

100021

NOT_YET_RECRUITING

Cancer Institute & Hospital, Chinese Academy of Medical Sciences, Beijing

250117

NOT_YET_RECRUITING

Shandong Province Tumor Hospital, Jinan

300060

NOT_YET_RECRUITING

Tianjin Medical University Cancer Institute & Hospital, Tianjin

300195

RECRUITING

National Taiwan University Hospital Hsin-Chu Branch, Hsinchu

310006

NOT_YET_RECRUITING

The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou

06520-8028

RECRUITING

Yale University School of Medicine - Yale Cancer Center, New Haven

02114

RECRUITING

Massachusetts General Hospital, Boston

02215

RECRUITING

Dana-Farber Cancer Institute, Boston

0200120

NOT_YET_RECRUITING

Shanghai East Hospital, Tongji University, Shanghai

277-8577

RECRUITING

National Cancer Center Hospital East, Chiba

606-8507

RECRUITING

Kyoto University Hospital, Kyoto

411-8777

RECRUITING

Shizuoka Cancer Center, Shizuoka

104-0045

RECRUITING

National Cancer Center Hospital, Tokyo

135-8550

RECRUITING

Cancer Institute Hospital of JFCR, Tokyo

08003

RECRUITING

Hospital del Mar, Barcelona

08035

RECRUITING

Hospital Universitario Vall d'Hebron, Barcelona

08908

RECRUITING

Institut Catala d'Oncologia - L'Hospitalet, Barcelona

All Listed Sponsors
lead

Eli Lilly and Company

INDUSTRY