A Study to Evaluate the Efficacy and Safety of GDC-8264 in Preventing Cardiac Surgery-Associated Acute Kidney Injury (AKI) and Major Adverse Kidney Events (MAKE)

PHASE2RecruitingINTERVENTIONAL
Enrollment

404

Participants

Timeline

Start Date

January 17, 2025

Primary Completion Date

November 15, 2027

Study Completion Date

November 15, 2027

Conditions
Acute Kidney Injury
Interventions
DRUG

GDC-8264

GDC-8264 will be administered as per pre-defined regimen.

DRUG

Placebo

Placebo will be administered as per pre-defined regimen.

Trial Locations (35)

1023

RECRUITING

Auckland City Hospital, Auckland

3000

RECRUITING

UZ Leuven, Leuven

3600

RECRUITING

ZOL Genk campus Sint Jan, Genk

4000

RECRUITING

Hopital de la Citadelle, Liège

4215

RECRUITING

Gold Coast University Hospital, Southport

4810

RECRUITING

Townsville Hospital, Townsville

10032

RECRUITING

Columbia University Irving Medical Center, New York

12808

RECRUITING

Vseobecna fakultni nemocnice v Praze, Prague

14004

RECRUITING

C.H. Regional Reina Sofia - PPDS, Córdoba

19140

RECRUITING

Temple University Hospital, Philadelphia

22908

RECRUITING

University of Virginia Health System, Charlottesville

27705

RECRUITING

Duke University Medical Center, Durham

28006

RECRUITING

Hospital Universitario de La Princesa, Madrid

49933

RECRUITING

CHU Angers, Angers

51092

RECRUITING

CHU de Reims, Reims

53215

RECRUITING

Aurora St Lukes Medical Center, Milwaukee

75013

RECRUITING

APHP - Hopital de la Pitie Salpetriere, Paris

90095

RECRUITING

Ronald Reagan UCLA Medical Center, Los Angeles

99999

RECRUITING

Richmond VA Medical Center NAVREF PPDS, Richmond

94305-2200

RECRUITING

University of Stanford Medical Center, Stanford

06519-1369

RECRUITING

Yale School of Medicine Yale New Haven Hospital, New Haven

33612-4745

RECRUITING

James A Haley Veteran Affairs Medical Center - NAVREF - PPDS, Tampa

01107

RECRUITING

Baystate Cardiac Surgery, Springfield

55905-0001

RECRUITING

Mayo Clinic - PPDS, Rochester

68526-9437

RECRUITING

CHI Health Nebraska Heart, Lincoln

27157-0001

RECRUITING

Atrium Health Wake Forest University School of Medicine - PPDS, Winston-Salem

75390-7202

RECRUITING

University of Texas Southwestern Medical Center, Dallas

E2L 4L2

RECRUITING

Saint John Regional Hospital, Saint John

150 06

RECRUITING

Fakultni nemocnice v Motole, Prague

01307

RECRUITING

Herzzentrum Dresden GmbH Universitatsklinikum, Dresden

03722

RECRUITING

Severance Hospital Yonsei University Health System - PPDS, Seoul

06351

RECRUITING

Samsung Medical Center - PPDS, Seoul

08916

RECRUITING

Hospital Universitario Germans Trias i Pujol, Badalona

EH16 4SA

RECRUITING

Royal Infirmary of Edinburgh, Edinburgh

SO16 6YD

RECRUITING

Southampton General Hospital, Southampton

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Genentech, Inc.

INDUSTRY

NCT06602453 - A Study to Evaluate the Efficacy and Safety of GDC-8264 in Preventing Cardiac Surgery-Associated Acute Kidney Injury (AKI) and Major Adverse Kidney Events (MAKE) | Biotech Hunter | Biotech Hunter