NCT06599502 - A Phase I/IIa Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Efficacy of AZD0022 as Monotherapy and in Combination With Anti-cancer Agents in Adult Participants With Tumours Harbouring a KRASG12D Mutation | Biotech Hunter

Enrollment

430

Participants

Timeline

Start Date

October 18, 2024

Primary Completion Date

January 20, 2028

Study Completion Date

January 20, 2028

Conditions

Advanced Solid TumoursNon-Small Cell Lung Cancer (NSCLC)Pancreatic Ductal Adenocarcinoma (PDAC)Colorectal Cancer (CRC)

Interventions

DRUG

AZD0022

AZD0022 is an oral KRASG12D inhibitor that blocks KRASG12D function in patients with this type of mutation.

DRUG

Cetuximab

Cetuximab (Erbitux®) is a recombinant chimeric human/mouse Immunoglobulin G monoclonal antibody which binds to EGFR and competitively inhibits the binding of EGFR and other ligands

Trial Locations (40)

2650

RECRUITING

Research Site, Edegem

3000

RECRUITING

Research Site, Melbourne

RECRUITING

Research Site, Leuven

5505

RECRUITING

Research Site, Seoul

10016

RECRUITING

Research Site, New York

10400

NOT_YET_RECRUITING

Research Site, Bangkok

10700

NOT_YET_RECRUITING

Research Site, Bangkok

20132

RECRUITING

Research Site, Milan

22031

RECRUITING

Research Site, Fairfax

28007

RECRUITING

Research Site, Madrid

28027

RECRUITING

Research Site, Madrid

34718

NOT_YET_RECRUITING

Research Site, Istanbul

37134

NOT_YET_RECRUITING

Research Site, Verona

37203

RECRUITING

Research Site, Nashville

46026

RECRUITING

Research Site, Valencia

78229

RECRUITING

Research Site, San Antonio

80131

NOT_YET_RECRUITING

Research Site, Napoli

91010

RECRUITING

Research Site, Duarte

100142

NOT_YET_RECRUITING

Research Site, Beijing

450008

NOT_YET_RECRUITING

Research Site, Zhengzhou

610041

RECRUITING

Research Site, Chengdu

999077

NOT_YET_RECRUITING

Research Site, Hong Kong

94305-5847

RECRUITING

Research Site, Stanford

T6G 1Z2

RECRUITING

Research Site, Edmonton

M5G 1X5

RECRUITING

Research Site, Toronto

H3A 1A1

RECRUITING

Research Site, Montreal

227-8577

RECRUITING

Research Site, Kashiwa

104-0045

RECRUITING

Research Site, Tokyo

1066CX

RECRUITING

Research Site, Amsterdam

80-214

RECRUITING

Research Site, Gdansk

93-513

RECRUITING

Research Site, Lodz

03080

RECRUITING

Research Site, Seoul

06351

RECRUITING

Research Site, Seoul

120-752

RECRUITING

Research Site, Seoul

08035

RECRUITING

Research Site, Barcelona

08908

RECRUITING

Research Site, L'Hospitalet de Llobregat

06800

NOT_YET_RECRUITING

Research Site, Ankara

CB2 0QQ

NOT_YET_RECRUITING

Research Site, Cambridge

M20 4BX

NOT_YET_RECRUITING

Research Site, Manchester

NE7 7DN

NOT_YET_RECRUITING

Research Site, Newcastle upon Tyne