30,240
Participants
Start Date
June 1, 2024
Primary Completion Date
July 31, 2026
Study Completion Date
March 31, 2027
The comprehensive TDA based approach
"The intervention consists of implementing a comprehensive TDA-based approach for TB diagnosis and treatment decision-making, including shorter treatment for non-severe TB in children identified as TB presumptive cases through a CDSS. It will also include the management of high-risk groups. In practice, all sick children will be assessed using the WHO-suggested TDAs A with CXR (DH) and B without CXR (PHC). CLHIV and those hospitalised with SAM at DH will have further assessment and treatment decisions based on the PAANTHER and TB-Speed SAM TDAs, respectively.~Clinical and microbiological assessment data will be incorporated into a CDSS to help with the clinical decision to initiate TB treatment. The CDSS will incorporate specific features and test results for high-risk group children based on the PAANTHER TDA and the TB-Speed SAM TDA and will incorporate the results of the severity assessment to guide the choice of TB treatment duration once children are diagnosed with TB."
RECRUITING
Chawama Urban Health Centre, Chingola
RECRUITING
Chiwempala Urban Health Centre, Chingola
RECRUITING
Kabundi East Urban Health Clinic, Chingola
RECRUITING
Kasompe Urban Health Centre, Chingola
RECRUITING
Muchinshi Rural Health Centre, Chingola
RECRUITING
Nchanga 1 Urban Health Centre, Chingola
RECRUITING
Nchanga North Referal Hospital, Chingola
RECRUITING
Allessandras Urban Health Centre, Luanshya
RECRUITING
Chaisa Urban Health Centre, Luanshya
RECRUITING
Fisenge Urban Health Centre, Luanshya
RECRUITING
Kawama Urban Health Centre, Luanshya
RECRUITING
Malaika Urban Health Centre, Luanshya
RECRUITING
Mikomfwa Urban Health Centre, Luanshya
RECRUITING
Roan Antelope General Hospital, Luanshya
RECRUITING
Thomson District Hospital, Luanshya
RECRUITING
Chipepo Rural Health Centre, Chirundu
RECRUITING
Hachipilika Rural Health Centre, Chirundu
RECRUITING
Jamba Rural Health Centre, Chirundu
RECRUITING
Kapululira Rural Health Centre, Chirundu
RECRUITING
Lusitu Rural Health Centre, Chirundu
RECRUITING
Mtendere Mission Referal hospital, Chirundu
RECRUITING
Sikoongo Rural Health Centre, Chirundu
RECRUITING
Habulile Rural Health Centre, Kalomo
RECRUITING
Kalomo District Hospital, Kalomo
RECRUITING
Kalomo Urban Health Centre, Kalomo
RECRUITING
Mawaya Urban Health Centre, Kalomo
RECRUITING
Namwianga Urban Health Centre, Kalomo
RECRUITING
Nkandanzovu Rural Health Centre, Kalomo
RECRUITING
Siachitema Rural Health Centre, Kalomo
Collaborators (1)
University of Bordeaux
OTHER
Instituto Nacional de Saúde, Mozambique
OTHER_GOV
ADERA
UNKNOWN
University of Stellenbosch
OTHER
Imperial College London
OTHER
Institut de Recherche pour le Développement (IRD)
UNKNOWN
University of Sheffield
OTHER
Ludwig-Maximilians - University of Munich
OTHER
Ministry of Health, Zambia
OTHER_GOV
Ministry of Health, Mozambique
OTHER_GOV
Eduardo Mondlane University
OTHER
European and Developing Countries Clinical Trials Partnership (EDCTP)
OTHER_GOV
Chishala Chabala
OTHER