Perioperative Rehabilitation Therapy in Patients Undergoing Liver Transplantation

NANot yet recruitingINTERVENTIONAL
Enrollment

750

Participants

Timeline

Start Date

October 1, 2024

Primary Completion Date

December 31, 2027

Study Completion Date

December 31, 2027

Conditions
Liver TransplantationSarcopenia
Interventions
DIETARY_SUPPLEMENT

BCAA Nutritional Intervention

Patients will receive BCAA nutritional supplements. The supplement is taken orally twice daily, with each sachet containing 10g of powder, of which 6g is BCAA, and the remainder consists of preservatives and fruit flavorings to enhance palatability. The morning dose is taken with breakfast, and the second dose is taken as a late evening snack after dinner. For critically ill patients, enteral nutrition is provided instead. During each follow-up visit, patients are required to retain and submit all empty and unused sachets to accurately assess compliance. Dietitians will adjust the type and amount of food for each patient according to the guidelines of the European Society for Parenteral and Enteral Nutrition to ensure a total caloric intake of 35-40 kcal/kg and a protein intake of 1.2-1.5 g/kg (including BCAA supplements).

BEHAVIORAL

Muscle Rehabilitation Training

Phase 1: Resistance Training (During Hospital Stay, First Month) Phase 2: Resistance Training (Home-Based, From Hospital Discharge Until 3 Months Post-Surgery) Phase 3: Physical Activity Training (Post-Surgery, After 3 Months)

DIETARY_SUPPLEMENT

Standard Nutritional Therapy

Standard Nutritional Therapy

All Listed Sponsors
lead

Zhejiang University

OTHER

NCT06591507 - Perioperative Rehabilitation Therapy in Patients Undergoing Liver Transplantation | Biotech Hunter | Biotech Hunter