Combining Aspirin With Ticagrelor or Cilostazol in Large-vessel Minor Stroke or TIA

PHASE3RecruitingINTERVENTIONAL
Enrollment

900

Participants

Timeline

Start Date

August 10, 2024

Primary Completion Date

September 19, 2025

Study Completion Date

October 1, 2025

Conditions
Ischemic Stroke
Interventions
DRUG

Ticagrelor 90 MG

The ticagrelor arm will receive (a 180mg loading dose of cilostazol during the first 24 hours of stroke onset, followed by 90mg once daily from the 2nd day to the 90th day) and an open-label loading 300 mg aspirin, followed by a maintenance dose of 75 mg aspirin

DRUG

Cilostazol 100 MG

The cilostazol arm will receive (a 200 mg loading dose of clopidogrel during the first 24 hours of stroke onset, followed by 100 mg twice daily from the 2nd day to the 90th day) and open-label loading 300 mg aspirin, followed by a maintenance dose of 75 mg aspirin.

DRUG

Aspirin 75mg

The ticagrelor arm will receive (a 180mg loading dose of cilostazol during the first 24 hours of stroke onset, followed by 90mg once daily from the 2nd day to the 90th day) and an open-label loading 300 mg aspirin, followed by a maintenance dose of 75 mg aspirin

DRUG

Aspirin 75mg

The cilostazol arm will receive (a 200 mg loading dose of clopidogrel during the first 24 hours of stroke onset, followed by 100 mg twice daily from the 2nd day to the 90th day) and open-label loading 300 mg aspirin, followed by a maintenance dose of 75 mg aspirin.

Trial Locations (2)

22514

RECRUITING

El-sahel teaching hospital, Cairo

33511

RECRUITING

Kafr Elsheikh University Hospital, Kafr ash Shaykh

All Listed Sponsors
collaborator

El-Sahel Teaching Hospital

OTHER_GOV

lead

Kafrelsheikh University

OTHER