Comparative Study Between Photodynamic Therapy with LED Associated with Probiotics in the Treatment of Halitosis

PHASE1RecruitingINTERVENTIONAL
Enrollment

92

Participants

Timeline

Start Date

November 1, 2024

Primary Completion Date

November 30, 2025

Study Completion Date

December 30, 2025

Conditions
Halitosis
Interventions
PROCEDURE

Oral hygiene at home

Participant will be taught on how to correctly brush their teeth, use dental floss and scrape their tongues at home.

PROCEDURE

aPDT

A weekly aPDT session will be performed for a period of 30 days, with the photosensitizer (PS) annatto manipulated at a concentration of 20% (Fórmula e Ação®). 2 ml (quantity measured with a pipette) will be applied to the middle third and dorsum of the tongue for 2 minutes for incubation (pre-irradiation time). The excess will be removed with a suction device in order to keep the surface moist with the PS itself. Six points will be irradiated with a distance of 1 cm between them, considering the light scattering halo; the LED will be positioned at a distance from the tongue so as to form a 2 cm halo at each point. The device will be previously calibrated with a wavelength of 395-480 nm, for 20 seconds per point, energy of 9.6 J.

DIETARY_SUPPLEMENT

Probiotics

Probiotic lozenges containing Streptococcus salivarius K12 (BLIS K12®) (OralBiotic; Master Products, Fort Lauderdale, Florida, United States) will be used. Each patient will receive 60 lozenges, which should be allowed to dissolve slowly and completely in the mouth. Patients are instructed to use the lozenges twice a day for a period of 30 days.

Trial Locations (1)

01525-000

RECRUITING

Nove de Julho University, São Paulo

All Listed Sponsors
lead

University of Nove de Julho

OTHER