Testing the Addition of an IDH2 Inhibitor, Enasidenib, to Usual Treatment (Cedazuridine-Decitabine) for Higher-Risk Myelodysplastic Syndrome (MDS) With IDH2 Mutation (A MyeloMATCH Treatment Trial)

PHASE2RecruitingINTERVENTIONAL
Enrollment

54

Participants

Timeline

Start Date

June 12, 2025

Primary Completion Date

March 1, 2027

Study Completion Date

March 1, 2027

Conditions
Myelodysplastic Syndrome
Interventions
PROCEDURE

Biospecimen Collection

Undergo buccal swab and blood sample collection

PROCEDURE

Bone Marrow Aspiration

Undergo bone marrow aspiration

PROCEDURE

Bone Marrow Biopsy

Undergo bone marrow biopsy

DRUG

Decitabine and Cedazuridine

Given PO

DRUG

Enasidenib

Given PO

Trial Locations (105)

14263

RECRUITING

Roswell Park Cancer Institute, Buffalo

15232

RECRUITING

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

17822

RECRUITING

Geisinger Medical Center, Danville

23298

RECRUITING

VCU Massey Comprehensive Cancer Center, Richmond

27710

RECRUITING

Duke University Medical Center, Durham

29316

RECRUITING

Prisma Health Cancer Institute - Spartanburg, Boiling Springs

29605

RECRUITING

Prisma Health Cancer Institute - Butternut, Greenville

RECRUITING

Prisma Health Cancer Institute - Faris, Greenville

29615

RECRUITING

Prisma Health Cancer Institute - Eastside, Greenville

29640

RECRUITING

Prisma Health Cancer Institute - Easley, Easley

29650

RECRUITING

Prisma Health Cancer Institute - Greer, Greer

29672

RECRUITING

Prisma Health Cancer Institute - Seneca, Seneca

40202

RECRUITING

The James Graham Brown Cancer Center at University of Louisville, Louisville

40245

RECRUITING

UofL Health Medical Center Northeast, Louisville

43210

RECRUITING

Ohio State University Comprehensive Cancer Center, Columbus

46307

RECRUITING

UChicago Medicine Northwest Indiana, Crown Point

48114

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Brighton, Brighton

48118

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital, Chelsea

48154

RECRUITING

Trinity Health Saint Mary Mercy Livonia Hospital, Livonia

48188

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Canton, Canton

48197

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti

48503

RECRUITING

Cancer Hematology Centers - Flint, Flint

SUSPENDED

Genesee Hematology Oncology PC, Flint

RECRUITING

Genesys Hurley Cancer Institute, Flint

53226

RECRUITING

Medical College of Wisconsin, Milwaukee

53705

RECRUITING

William S Middleton VA Medical Center, Madison

54301

RECRUITING

Saint Vincent Hospital Cancer Center Green Bay, Green Bay

54303

RECRUITING

Saint Vincent Hospital Cancer Center at Saint Mary's, Green Bay

54601

RECRUITING

Gundersen Lutheran Medical Center, La Crosse

54806

RECRUITING

Duluth Clinic Ashland, Ashland

55072

RECRUITING

Essentia Health Sandstone, Sandstone

55746

RECRUITING

Essentia Health Hibbing Clinic, Hibbing

55792

RECRUITING

Essentia Health Virginia Clinic, Virginia

55805

RECRUITING

Essentia Health Cancer Center, Duluth

56401

RECRUITING

Essentia Health Saint Joseph's Medical Center, Brainerd

56636

RECRUITING

Essentia Health - Deer River Clinic, Deer River

58103

RECRUITING

Essentia Health Cancer Center-South University Clinic, Fargo

59101

RECRUITING

Billings Clinic Cancer Center, Billings

59405

RECRUITING

Benefis Sletten Cancer Institute, Great Falls

59711

RECRUITING

Community Hospital of Anaconda, Anaconda

59804

RECRUITING

Community Medical Center, Missoula

59901

RECRUITING

Logan Health Medical Center, Kalispell

60026

RECRUITING

Northwestern Medicine Glenview Outpatient Center, Glenview

60030

RECRUITING

Northwestern Medicine Grayslake Outpatient Center, Grayslake

60045

RECRUITING

Northwestern Medicine Lake Forest Hospital, Lake Forest

60115

RECRUITING

Northwestern Medicine Cancer Center Kishwaukee, DeKalb

60134

RECRUITING

Northwestern Medicine Cancer Center Delnor, Geneva

60451

RECRUITING

UC Comprehensive Cancer Center at Silver Cross, New Lenox

60462

RECRUITING

Northwestern Medicine Orland Park, Orland Park

RECRUITING

University of Chicago Medicine-Orland Park, Orland Park

60555

RECRUITING

Northwestern Medicine Cancer Center Warrenville, Warrenville

60611

RECRUITING

Northwestern University, Chicago

60637

RECRUITING

University of Chicago Comprehensive Cancer Center, Chicago

61021

RECRUITING

Illinois CancerCare-Dixon, Dixon

61350

RECRUITING

Illinois CancerCare-Ottawa Clinic, Ottawa

61354

RECRUITING

Illinois CancerCare-Peru, Peru

61356

RECRUITING

Illinois CancerCare-Princeton, Princeton

61401

RECRUITING

Illinois CancerCare-Galesburg, Galesburg

61443

RECRUITING

Illinois CancerCare-Kewanee Clinic, Kewanee

61455

RECRUITING

Illinois CancerCare-Macomb, Macomb

61520

RECRUITING

Illinois CancerCare-Canton, Canton

61530

RECRUITING

Illinois CancerCare-Eureka, Eureka

61554

RECRUITING

Illinois CancerCare-Pekin, Pekin

61571

RECRUITING

Illinois CancerCare - Washington, Washington

61615

RECRUITING

Illinois CancerCare-Peoria, Peoria

61704

RECRUITING

Illinois CancerCare-Bloomington, Bloomington

61801

RECRUITING

Carle Cancer Center, Urbana

61832

RECRUITING

Carle at The Riverfront, Danville

61938

RECRUITING

Carle Physician Group-Mattoon/Charleston, Mattoon

62269

RECRUITING

Cancer Care Center of O'Fallon, O'Fallon

RECRUITING

HSHS Saint Elizabeth's Hospital, O'Fallon

62321

RECRUITING

Illinois CancerCare-Carthage, Carthage

62401

RECRUITING

Crossroads Cancer Center, Effingham

62526

RECRUITING

Cancer Care Specialists of Illinois - Decatur, Decatur

RECRUITING

Decatur Memorial Hospital, Decatur

62702

RECRUITING

Southern Illinois University School of Medicine, Springfield

RECRUITING

Springfield Clinic, Springfield

62781

RECRUITING

Springfield Memorial Hospital, Springfield

63080

RECRUITING

Missouri Baptist Sullivan Hospital, Sullivan

63127

RECRUITING

BJC Outpatient Center at Sunset Hills, Sunset Hills

63131

RECRUITING

Missouri Baptist Medical Center, St Louis

63640

RECRUITING

Parkland Health Center - Farmington, Farmington

63670

RECRUITING

Sainte Genevieve County Memorial Hospital, Sainte Genevieve

70805

RECRUITING

LSU Health Baton Rouge-North Clinic, Baton Rouge

70808

RECRUITING

Our Lady of the Lake Physician Group, Baton Rouge

RECRUITING

Our Lady of The Lake, Baton Rouge

73104

RECRUITING

University of Oklahoma Health Sciences Center, Oklahoma City

83619

RECRUITING

Saint Luke's Cancer Institute - Fruitland, Fruitland

83642

RECRUITING

Saint Luke's Cancer Institute - Meridian, Meridian

83687

RECRUITING

Saint Luke's Cancer Institute - Nampa, Nampa

83712

RECRUITING

Saint Luke's Cancer Institute - Boise, Boise

83814

RECRUITING

Kootenai Health - Coeur d'Alene, Coeur d'Alene

83854

RECRUITING

Kootenai Clinic Cancer Services - Post Falls, Post Falls

83864

RECRUITING

Kootenai Clinic Cancer Services - Sandpoint, Sandpoint

84112

RECRUITING

Huntsman Cancer Institute/University of Utah, Salt Lake City

87106

RECRUITING

University of New Mexico Cancer Center, Albuquerque

94401

RECRUITING

Mills Health Center, San Mateo

94704

RECRUITING

Alta Bates Summit Medical Center-Herrick Campus, Berkeley

98026

RECRUITING

Swedish Cancer Institute-Edmonds, Edmonds

98029

RECRUITING

Swedish Cancer Institute-Issaquah, Issaquah

98122

RECRUITING

Swedish Medical Center-First Hill, Seattle

02111

RECRUITING

Tufts Medical Center, Boston

08903

RECRUITING

Rutgers Cancer Institute of New Jersey, New Brunswick

00927

RECRUITING

Centro Comprensivo de Cancer de UPR, San Juan

00936

RECRUITING

San Juan City Hospital, San Juan

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH

NCT06577441 - Testing the Addition of an IDH2 Inhibitor, Enasidenib, to Usual Treatment (Cedazuridine-Decitabine) for Higher-Risk Myelodysplastic Syndrome (MDS) With IDH2 Mutation (A MyeloMATCH Treatment Trial) | Biotech Hunter | Biotech Hunter