NCT06572605View on ClinicalTrials.gov

External Beam Radiation Therapy in Combination With Talquetamab for the Treatment of Multiple Myeloma Patients With Extramedullary Disease

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

20

Participants

Timeline

Start Date

August 29, 2025

Primary Completion Date

January 18, 2030

Study Completion Date

January 18, 2030

Conditions
Extramedullary Disease in Multiple MyelomaMultiple Myeloma
Interventions
PROCEDURE

Biospecimen Collection

Undergo collection of blood samples

PROCEDURE

Bone Marrow Aspiration

Undergo bone marrow aspiration

PROCEDURE

Bone Marrow Biopsy

Undergo bone marrow biopsy

PROCEDURE

Computed Tomography

Undergo CT and/or PET/CT

OTHER

Electronic Health Record Review

Ancillary studies

RADIATION

External Beam Radiation Therapy

Undergo EMD-EBRT

PROCEDURE

Image Guided Biopsy

Undergo image-guided EMD biopsy

PROCEDURE

Positron Emission Tomography

Undergo PET/CT

BIOLOGICAL

Talquetamab

Given SC

Trial Locations (1)

91010

RECRUITING

City of Hope Medical Center, Duarte

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

City of Hope Medical Center

OTHER