A Phase III, Randomised Study of Adjuvant Dato-DXd in Combination With Rilvegostomig or Rilvegostomig Monotherapy Versus Standard of Care, Following Complete Tumour Resection, in Participants With Stage I Adenocarcinoma NSCLC Who Are ctDNA-positive or Have High-risk Pathological Features

PHASE3RecruitingINTERVENTIONAL
Enrollment

660

Participants

Timeline

Start Date

October 15, 2024

Primary Completion Date

May 19, 2033

Study Completion Date

January 19, 2035

Conditions
Non-small Cell Lung Cancer
Interventions
DRUG

Datopotamab Deruxtecan

Datopotamab Deruxtecan IV (intravenous)

DRUG

Rilvegostomig

Rilvegostomig IV (intravenous)

DRUG

Carboplatin

Carboplatin IV (intravenous), Active Comparator

DRUG

Cisplatin

Cisplatin IV (intravenous), Active Comparator

DRUG

Etoposide

Etoposide IV (intravenous), Active Comparator

DRUG

Pemetrexed

Pemetrexed IV (intravenous), Active Comparator

DRUG

Vinorelbine

Vinorelbine IV (intravenous), Active Comparator

DRUG

UFT

UFT Oral route of administration, Active Comparator

Trial Locations (228)

112

RECRUITING

Research Site, Taipei

114

RECRUITING

Research Site, Taipei

333

RECRUITING

Research Site, Taoyuan District

1033

WITHDRAWN

Research Site, Budapest

1083

NOT_YET_RECRUITING

Research Site, Budapest

1121

NOT_YET_RECRUITING

Research Site, Budapest

1122

NOT_YET_RECRUITING

Research Site, Budapest

2045

NOT_YET_RECRUITING

Research Site, Törökbálint

2050

NOT_YET_RECRUITING

Research Site, Camperdown

2650

NOT_YET_RECRUITING

Research Site, Edegem

3200

NOT_YET_RECRUITING

Research Site, Gyöngyös - Mátraháza

3500

NOT_YET_RECRUITING

Research Site, Hasselt

4032

NOT_YET_RECRUITING

Research Site, Debrecen

4810

NOT_YET_RECRUITING

Research Site, Townsville

6150

NOT_YET_RECRUITING

Research Site, Murdoch

6772

NOT_YET_RECRUITING

Research Site, Deszk

7624

NOT_YET_RECRUITING

Research Site, Pécs

8000

NOT_YET_RECRUITING

Research Site, Zalaegerszeg

8035

NOT_YET_RECRUITING

Research Site, Barcelona

8091

NOT_YET_RECRUITING

Research Site, Zurich

10002

RECRUITING

Research Site, Taipei

10016

RECRUITING

Research Site, New York

10065

RECRUITING

Research Site, New York

WITHDRAWN

Research Site, New York

10300

RECRUITING

Research Site, Dusit

10400

RECRUITING

Research Site, Bangkok

RECRUITING

Research Site, Ratchathewi

10450

RECRUITING

Research Site, George Town

10467

RECRUITING

Research Site, The Bronx

10601

WITHDRAWN

Research Site, White Plains

10700

RECRUITING

Research Site, Bangkoknoi

11501

RECRUITING

Research Site, Mineola

13057

RECRUITING

Research Site, East Syracuse

13915

WITHDRAWN

Research Site, Marseille

15212

RECRUITING

Research Site, Pittsburgh

15213

WITHDRAWN

Research Site, Pittsburgh

16247

NOT_YET_RECRUITING

Research Site, Suwon

18015

RECRUITING

Research Site, Bethlehem

19107

RECRUITING

Research Site, Philadelphia

19713

WITHDRAWN

Research Site, Newark

20007

RECRUITING

Research Site, Washington D.C.

20010

RECRUITING

Research Site, Washington D.C.

20089

NOT_YET_RECRUITING

Research Site, Rozzano

20090

NOT_YET_RECRUITING

Research Site, Monza

20422

NOT_YET_RECRUITING

Research Site, Washington D.C.

20910

RECRUITING

Research Site, Silver Spring

21201

NOT_YET_RECRUITING

Research Site, Baltimore

21202

RECRUITING

Research Site, Baltimore

21231

WITHDRAWN

Research Site, Baltimore

21237

RECRUITING

Research Site, Baltimore

21401

RECRUITING

Research Site, Annapolis

21565

NOT_YET_RECRUITING

Research Site, Incheon

21702

NOT_YET_RECRUITING

Research Site, Frederick

22031

RECRUITING

Research Site, Fairfax

WITHDRAWN

Research Site, Fairfax

23502

RECRUITING

Research Site, Norfolk

23538

WITHDRAWN

Research Site, Lübeck

27710

RECRUITING

Research Site, Durham

28040

NOT_YET_RECRUITING

Research Site, Madrid

29004

NOT_YET_RECRUITING

Research Site, Málaga

32224

RECRUITING

Research Site, Jacksonville

32763

RECRUITING

Research Site, Orange City

32803

WITHDRAWN

Research Site, Orlando

33136

RECRUITING

Research Site, Miami

33140

RECRUITING

Research Site, Miami Beach

33240

RECRUITING

Research Site, Mersin

33401

RECRUITING

Research Site, West Palm Beach

33705

RECRUITING

Research Site, St. Petersburg

33709

RECRUITING

Research Site, St. Petersburg

33901

RECRUITING

Research Site, Fort Myers

34214

RECRUITING

Research Site, Istanbul

34711

RECRUITING

Research Site, Clermont

35128

NOT_YET_RECRUITING

Research Site, Padua

35392

NOT_YET_RECRUITING

Research Site, Giessen

37203

RECRUITING

Research Site, Nashville

37920

RECRUITING

Research Site, Knoxville

38120

RECRUITING

Research Site, Memphis

40002

RECRUITING

Research Site, Muang

40503

RECRUITING

Research Site, Lexington

44106

WITHDRAWN

Research Site, Cleveland

44111

RECRUITING

Research Site, Cleveland

44124

RECRUITING

Research Site, Cleveland

44131

RECRUITING

Research Site, Independence

44195

RECRUITING

Research Site, Cleveland

45219

RECRUITING

Research Site, Cincinnati

45239

NOT_YET_RECRUITING

Research Site, Essen

45245

RECRUITING

Research Site, Cincinnati

46804

WITHDRAWN

Research Site, Fort Wayne

48109

WITHDRAWN

Research Site, Ann Arbor

48126

RECRUITING

Research Site, Dearborn

48163

NOT_YET_RECRUITING

Research Site, Münster

48197

WITHDRAWN

Research Site, Ypsilanti

48202

WITHDRAWN

Research Site, Detroit

48334

RECRUITING

Research Site, Farmington Hills

49124

NOT_YET_RECRUITING

Research Site, Georgsmarienhütte

49503

RECRUITING

Research Site, Grand Rapids

49933

NOT_YET_RECRUITING

Research Site, Angers

50009

NOT_YET_RECRUITING

Research Site, Zaragoza

50134

NOT_YET_RECRUITING

Research Site, Florence

50200

RECRUITING

Research Site, Muang

50586

RECRUITING

Research Site, Kuala Lumpur

53127

NOT_YET_RECRUITING

Research Site, Bonn

53792

NOT_YET_RECRUITING

Research Site, Madison

55407

RECRUITING

Research Site, Minneapolis

55805

RECRUITING

Research Site, Duluth

55905

RECRUITING

Research Site, Rochester

59100

RECRUITING

Research Site, Kuala Lumpur

59102

RECRUITING

Research Site, Billings

60099

RECRUITING

Research Site, Zion

60201

RECRUITING

Research Site, Evanston

60637

RECRUITING

Research Site, Chicago

62250

RECRUITING

Research Site, Kuala Selangor

63108

RECRUITING

Research Site, St Louis

66160

RECRUITING

Research Site, Kansas City

68105

NOT_YET_RECRUITING

Research Site, Omaha

68130

RECRUITING

Research Site, Omaha

70000

NOT_YET_RECRUITING

Research Site, Ho Chi Minh City

73730

NOT_YET_RECRUITING

Research Site, Esslingen am Neckar

74120

RECRUITING

Research Site, Banphaeo

75231

RECRUITING

Research Site, Dallas

75248

NOT_YET_RECRUITING

Research Site, Paris

75390

NOT_YET_RECRUITING

Research Site, Dallas

76031

NOT_YET_RECRUITING

Research Site, Rouen

76137

NOT_YET_RECRUITING

Research Site, Karlsruhe

77030

NOT_YET_RECRUITING

Research Site, Houston

77090

WITHDRAWN

Research Site, Houston

77598

RECRUITING

Research Site, Webster

78217

RECRUITING

Research Site, San Antonio

78745

RECRUITING

Research Site, Austin

80045

WITHDRAWN

Research Site, Aurora

80124

RECRUITING

Research Site, Lone Tree

80756

RECRUITING

Research Site, Kaohsiung City

82131

NOT_YET_RECRUITING

Research Site, Gauting

83000

NOT_YET_RECRUITING

Research Site, Toulon

83702

WITHDRAWN

Research Site, Boise

84112

NOT_YET_RECRUITING

Research Site, Salt Lake City

85054

RECRUITING

Research Site, Phoenix

85234

WITHDRAWN

Research Site, Gilbert

85724

RECRUITING

Research Site, Tucson

86301

RECRUITING

Research Site, Prescott

87439

NOT_YET_RECRUITING

Research Site, Kempten

89102

RECRUITING

Research Site, Las Vegas

90089

RECRUITING

Research Site, Los Angeles

90095

NOT_YET_RECRUITING

Research Site, Los Angeles

90110

RECRUITING

Research Site, Hat Yai

91010

RECRUITING

Research Site, Duarte

91204

RECRUITING

Research Site, Glendale

92123

NOT_YET_RECRUITING

Research Site, San Diego

92150

NOT_YET_RECRUITING

Research Site, Suresnes

92612

NOT_YET_RECRUITING

Research Site, Irvine

92663

RECRUITING

Research Site, Newport Beach

92708

RECRUITING

Research Site, Fountain Valley

92868

NOT_YET_RECRUITING

Research Site, Orange

93105

RECRUITING

Research Site, Santa Barbara

93586

RECRUITING

Research Site, Kuching

97067

NOT_YET_RECRUITING

Research Site, Würzburg

97213

WITHDRAWN

Research Site, Portland

97239

RECRUITING

Research Site, Portland

98026

RECRUITING

Research Site, Edmonds

98104

RECRUITING

Research Site, Seattle

98108

NOT_YET_RECRUITING

Research Site, Seattle

98109

WITHDRAWN

Research Site, Seattle

98383

NOT_YET_RECRUITING

Research Site, Silverdale

98684

RECRUITING

Research Site, Vancouver

99089

NOT_YET_RECRUITING

Research Site, Erfurt

100000

RECRUITING

Research Site, Hanoi

RECRUITING

Research Site, Hà Nội

460000

RECRUITING

Research Site, Vinh

550000

NOT_YET_RECRUITING

Research Site, Da Nang

700000

RECRUITING

Research Site, Ho Chi Minh City

999077

RECRUITING

Research Site, Hong Kong

NOT_YET_RECRUITING

Research Site, Hong Kong

02111

WITHDRAWN

Research Site, Boston

02114

WITHDRAWN

Research Site, Boston

02115

NOT_YET_RECRUITING

Research Site, Boston

01655

WITHDRAWN

Research Site, Worcester

08103

NOT_YET_RECRUITING

Research Site, Camden

14784-057

RECRUITING

Research Site, Barretos

70200-730

RECRUITING

Research Site, Brasília

88034-000

RECRUITING

Research Site, Florianópolis

01323-903

RECRUITING

Research Site, São Paulo

64049-200

RECRUITING

Research Site, Teresina

A1B 3V6

WITHDRAWN

Research Site, St. John's

B3H 2Y9

RECRUITING

Research Site, Halifax

L3Y 2R2

WITHDRAWN

Research Site, Newmarket

L1G 2B9

RECRUITING

Research Site, Oshawa

J4V 2H1

RECRUITING

Research Site, Greenfield Park

H2X 3J4

RECRUITING

Research Site, Montreal

S7M 0Z9

NOT_YET_RECRUITING

Research Site, Saskatoon

07548

NOT_YET_RECRUITING

Research Site, Gera

00144

NOT_YET_RECRUITING

Research Site, Roma

00168

NOT_YET_RECRUITING

Research Site, Roma

113-8603

RECRUITING

Research Site, Bunkyō City

260-0877

RECRUITING

Research Site, Chiba

104-0045

RECRUITING

Research Site, Chūōku

812-8582

RECRUITING

Research Site, Fukuoka

350-1298

RECRUITING

Research Site, Hidaka-shi

730-8518

RECRUITING

Research Site, Hiroshima

734-8551

RECRUITING

Research Site, Hiroshima

740-8510

RECRUITING

Research Site, Iwakuni-shi

277-8577

RECRUITING

Research Site, Kashiwa

362-0806

RECRUITING

Research Site, Kitaadachi-gun

650-0017

RECRUITING

Research Site, Kobe

135-8550

RECRUITING

Research Site, Kōtoku

860-8556

RECRUITING

Research Site, Kumamoto

464-8681

RECRUITING

Research Site, Nagoya

951-8566

RECRUITING

Research Site, Niigata

589-8511

RECRUITING

Research Site, Osakasayama-shi

003-0804

RECRUITING

Research Site, Sapporo

980-0873

RECRUITING

Research Site, Sendai

980-8574

RECRUITING

Research Site, Sendai

641-8510

RECRUITING

Research Site, Wakayama

241-8515

RECRUITING

Research Site, Yokohama

3015 GD

NOT_YET_RECRUITING

Research Site, Rotterdam

10-357

NOT_YET_RECRUITING

Research Site, Olsztyn

60-569

NOT_YET_RECRUITING

Research Site, Poznan

01-138

NOT_YET_RECRUITING

Research Site, Warsaw

03722

NOT_YET_RECRUITING

Research Site, Seoul

05505

NOT_YET_RECRUITING

Research Site, Seoul

06351

NOT_YET_RECRUITING

Research Site, Seoul

03010

NOT_YET_RECRUITING

Research Site, Alicante

08003

NOT_YET_RECRUITING

Research Site, Badalona

171 76

NOT_YET_RECRUITING

Research Site, Solna

06010

RECRUITING

Research Site, Ankara

06280

RECRUITING

Research Site, Ankara

LS9 7TF

RECRUITING

Research Site, Leeds

SE1 9RT

NOT_YET_RECRUITING

Research Site, London

NG5 1PB

NOT_YET_RECRUITING

Research Site, Nottingham

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

Daiichi Sankyo

INDUSTRY

lead

AstraZeneca

INDUSTRY