Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant

PHASE3RecruitingINTERVENTIONAL
Enrollment

582

Participants

Timeline

Start Date

May 12, 2025

Primary Completion Date

October 31, 2031

Study Completion Date

December 31, 2032

Conditions
AmyloidosisAmyloid CardiomyopathyTransthyretin AmyloidosisCardiomyopathiesHeart DiseasesPolyneuropathies
Interventions
DRUG

Acoramidis

TTR stabilizer administered orally twice daily (BID)

DRUG

Placebo oral tablet

Non-active control administered orally twice daily (BID)

Trial Locations (53)

500

RECRUITING

Changhua Christian Hospital - Taiwan, Changhua

10016

RECRUITING

New York University (NYU) School of Medicine - Langone Medical Center, New York

10029

RECRUITING

Mount Sinai Hospital, New York

10032

RECRUITING

Columbia University Medical Center, New York

10117

RECRUITING

Charite Universitaetsmedizin Berlin, Berlin

11217

RECRUITING

Taipei Veterans General Hospital, Taipei

11422

RECRUITING

Laurelton Heart Specialists, Rosedale

20010

RECRUITING

MedStar Washington Hospital Center - MedStar Heart and Vascular Institute, Washington D.C.

21201

RECRUITING

University of Maryland Medical Center, Baltimore

21287

RECRUITING

Johns Hopkins University, Baltimore

23219

RECRUITING

Virginia Commonwealth University, Richmond

27100

RECRUITING

Fondazione IRCCS Policlinico San Matteo, Pavia

27710

RECRUITING

Duke University Medical Center, Durham

29425

RECRUITING

Medical University of South Carolina (MUSC), Charleston

30322

RECRUITING

Emory University School of Medicine, Atlanta

31400

RECRUITING

CHU de Toulouse - Hopital Rangueil, Toulouse

32224

RECRUITING

Mayo Clinic - Jacksonville, Jacksonville

35000

RECRUITING

CHU Rennes, Rennes

37007

RECRUITING

Hospital Clinico Universitario de Salamanca, Salamanca

40138

RECRUITING

Azienda Ospedaliero-Universitaria di Bologna IRCCS Policlinico di S.Orsola, Bologna

48202

RECRUITING

Henry Ford Health System, Detroit

55905

RECRUITING

Mayo Clinic - Rochester, Rochester

56124

RECRUITING

Fondazione Toscana Gabriele Monasterio per la Ricerca Medica e di Sanità Pubblica - Ospedale San Cataldo, Pisa

59100

RECRUITING

University Malaya Medical Centre (UMMC), Kuala Lumpur

60612

RECRUITING

John H. Stroger, Jr. Hospital of Cook County, Chicago

63110

RECRUITING

Washington University in St. Louis, St Louis

64111

RECRUITING

St. Luke's Hospital of Kansas City, Kansas City

78759

RECRUITING

National Neuromuscular Research Institute, Austin

89605

RECRUITING

Prisma Health Cancer Institute, Greenville

92037

RECRUITING

University of California, San Diego (UCSD) - Medical Center, La Jolla

94270

RECRUITING

AP-HP Hopital Bicetre, Le Kremlin-Bicêtre

94305

RECRUITING

Stanford University, Stanford

97239

RECRUITING

Oregon Health & Science University, Portland

169608

RECRUITING

Singapore General Hospital, Singapore

06519

RECRUITING

Yale University School of Medicine - Section of Cardiology, New Haven

02114

RECRUITING

Massachusetts General Hospital, Boston

02115

RECRUITING

Brigham and Women's Hospital, Boston

08901

RECRUITING

Rutgers-Robert Wood Johnson Medical School, New Brunswick

T2N 4Z6

RECRUITING

University of Calgary, Calgary

Unknown

RECRUITING

Azienda Ospedaliero-Universitaria Careggi, Florence

RECRUITING

Hospital Universitario Juan Ramon Jimenez, Huelva

RECRUITING

Hospital Universitario Puerta de Hierro, Majadahonda

00168

RECRUITING

Fondazione Policlinico Universitario A. Gemelli IRCCS - Universita Cattolica del Sacro Cuore, Rome

00189

RECRUITING

Azienda Ospedaliero-Universitaria Sant'Andrea, Rome

9713 GZ

RECRUITING

University Medical Center Groningen, Groningen

3584 CX

RECRUITING

Universitair Medisch Centrum Utrecht, Utrecht

1649-035

RECRUITING

Unidade Local de Saude de Santa Maria EPE - Hospital de Santa Maria, Lisbon

03080

RECRUITING

Seoul National University Hospital, Seoul

03722

RECRUITING

Severance Hospital, Yonsei University Health System, Seoul

06351

RECRUITING

Samsung Medical Center, Seoul

06591

RECRUITING

Seoul St. Mary's Hospital, Seoul

08907

RECRUITING

Hospital Universitari de Bellvitge, Barcelona

07198

RECRUITING

Hospital Universitario Son Llatzer, Palma de Mallorca

All Listed Sponsors
lead

Eidos Therapeutics, a BridgeBio company

INDUSTRY