A Study to Compare the Efficacy of Nivolumab and Relatlimab Plus Chemotherapy vs Pembrolizumab Plus Chemotherapy for Stage IV/Recurrent Non-squamous Non-small Cell Lung Cancer With PD-L1 Expression ≥ 1%

PHASE3RecruitingINTERVENTIONAL
Enrollment

1,000

Participants

Timeline

Start Date

October 7, 2024

Primary Completion Date

July 30, 2030

Study Completion Date

August 4, 2032

Conditions
Non-small Cell Lung Cancer
Interventions
DRUG

Nivolumab

Specified dose on specified days

DRUG

Relatlimab

Specified dose on specified days

DRUG

Pembrolizumab

Specified dose on specified days

DRUG

Carboplatin

Specified dose on specified days

DRUG

Pemetrexed

Specified dose on specified days

DRUG

Cisplatin

Specified dose on specified days

Trial Locations (277)

0

RECRUITING

Orlandi Oncologia, Santiago

NOT_YET_RECRUITING

Local Institution - 0415, Medellín

NOT_YET_RECRUITING

Local Institution - 0443, Bogotá

235

RECRUITING

Taipei Medical University Shuang Ho Hospital, New Taipei City

407

RECRUITING

Taichung Veterans General Hospital, Taichung

1011

NOT_YET_RECRUITING

Local Institution - 0291, Lausanne

1023

NOT_YET_RECRUITING

Local Institution - 0405, Auckland

1090

RECRUITING

UZ Brussel, Brussels

1210

NOT_YET_RECRUITING

Local Institution - 0293, Vienna

1280

RECRUITING

Hospital Británico de Buenos Aires, Ciudad Autónoma de Buenos Aires

2013

NOT_YET_RECRUITING

Local Institution - 0431, Soweto

2065

RECRUITING

GenesisCare North Shore, St Leonards

2100

RECRUITING

Rigshospitalet, Copenhagen

2193

NOT_YET_RECRUITING

Local Institution - 0429, Johannesburg

2196

NOT_YET_RECRUITING

Local Institution - 0427, Sandton

2250

RECRUITING

Gosford Hospital, Gosford

2650

RECRUITING

Antwerp University Hospital, Edegem

3040

NOT_YET_RECRUITING

Local Institution - 0404, Coimbra

3112

NOT_YET_RECRUITING

Local Institution - 0407, Tauranga

NOT_YET_RECRUITING

Local Institution - 0447, Tauranga

3128

RECRUITING

Box Hill Hospital, Box Hill

3500

NOT_YET_RECRUITING

Local Institution - 0314, Krems

RECRUITING

Jessa Ziekenhuis, Hasselt

4000

RECRUITING

Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman, Liège

4031

NOT_YET_RECRUITING

Local Institution - 0290, Basel

4032

RECRUITING

The Prince Charles Hospital, Brisbane

4120

RECRUITING

Gallipoli Medical Research Ltd, Brisbane

4600

NOT_YET_RECRUITING

Local Institution - 0292, Wels

5016

RECRUITING

Hospital Privado Universitario de Córdoba, Córdoba

5112

NOT_YET_RECRUITING

Local Institution - 0057, Elizabeth Vale

5530

RECRUITING

Université Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant-Godinne - Site Godinne, Yvoir

6021

NOT_YET_RECRUITING

Local Institution - 0406, Wellington

6150

RECRUITING

Fiona Stanley Hospital, Murdoch

RECRUITING

St. John of God Murdoch Hospital, Murdoch

6400

RECRUITING

Sygehus Soenderjylland, Sønderborg

6500

NOT_YET_RECRUITING

Local Institution - 0341, Bellinzona

7570

NOT_YET_RECRUITING

Local Institution - 0428, Cape Town

7600

RECRUITING

Hospital Privado de Comunidad, Mar del Plata

8200

RECRUITING

Aarhus Universitetshospital, Skejby, Aarhus

8596

NOT_YET_RECRUITING

Local Institution - 0398, Münsterlingen

8800

RECRUITING

AZ Delta vzw, Roeselare

9016

NOT_YET_RECRUITING

Local Institution - 0425, Dunedin

10002

RECRUITING

National Taiwan University Hospital, Taipei

10016

RECRUITING

Veterans Affairs New York Harbor Healthcare System, New York

10408

RECRUITING

National Cancer Center, Goyang-si

10468

WITHDRAWN

Local Institution - 0357, The Bronx

10532

RECRUITING

WMCHealth Advanced Physician Services, Hawthorne

11217

RECRUITING

Taipei Veterans General Hospital, Taipei

11426

NOT_YET_RECRUITING

Local Institution - 0408, Riyadh

11768

WITHDRAWN

Local Institution - 0380, Northport

13210

RECRUITING

SUNY Upstate Medical University, Syracuse

13353

RECRUITING

Charité Campus Virchow-Klinikum, Berlin

13496

RECRUITING

CHA Bundang Medical Center, CHA University, Seongnam-si

13915

NOT_YET_RECRUITING

Local Institution - 0158, Marseille

14642

NOT_YET_RECRUITING

Local Institution - 0325, Rochester

15006

NOT_YET_RECRUITING

Local Institution - 0270, A Coruña

17601

RECRUITING

Lancaster General Hospital - Ann B Barshinger Cancer Institute, Lancaster

20900

NOT_YET_RECRUITING

Local Institution - 0045, Monza

21565

RECRUITING

Gachon University Gil Medical Center, Namdong-gu

22927

RECRUITING

LungenClinic Grosshansdorf, Großhansdorf

23433

NOT_YET_RECRUITING

Local Institution - 0409, Jeddah

27858

NOT_YET_RECRUITING

Local Institution - 0351, Greenville

28034

RECRUITING

Hospital Universitario Ramón y Cajal, Madrid

28041

RECRUITING

Hospital Universitario 12 de Octubre, Madrid

28222

RECRUITING

Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda

28644

RECRUITING

Chungbuk National University Hospital, Cheongju-si

28806

RECRUITING

Messino Cancer Centers, Asheville

29011

RECRUITING

H.R.U Málaga - Hospital General, Málaga

29200

NOT_YET_RECRUITING

Local Institution - 0462, Brest

30161

RECRUITING

Praxis Onkologie am Raschplatz, Hanover

31059

NOT_YET_RECRUITING

Local Institution - 0090, Toulouse

31444

NOT_YET_RECRUITING

Local Institution - 0440, Dammam

33028

RECRUITING

Memorial Hospital West, Pembroke Pines

33136

RECRUITING

University of Miami Hospital and Clinics, Sylvester Cancer Center, Miami

33401

RECRUITING

Florida Cancer Specialists - East, West Palm Beach

33705

RECRUITING

Florida Cancer Specialists - North, St. Petersburg

34214

NOT_YET_RECRUITING

Local Institution - 0410, Istanbul

34298

WITHDRAWN

Local Institution - 0092, Montpellier

34722

NOT_YET_RECRUITING

Local Institution - 0364, Istanbul

35033

WITHDRAWN

Local Institution - 0093, Rennes

RECRUITING

Universitätsklinikum Marburg, Marburg

37019

RECRUITING

Casa di Cura Dott. Pederzoli, Peschiera del Garda

40503

NOT_YET_RECRUITING

Local Institution - 0130, Lexington

41013

RECRUITING

Hospital Universitario Virgen Del Rocio, Seville

41017

RECRUITING

Saint Elizabeth Medical Center Edgewood, Edgewood

44106

RECRUITING

Louis Stokes Cleveland VA Medical Center, Cleveland

44260

NOT_YET_RECRUITING

Local Institution - 0170, Guadalajara

44646

WITHDRAWN

Local Institution - 0366, Massillon

44651

NOT_YET_RECRUITING

Local Institution - 0397, Herne

44708

WITHDRAWN

Local Institution - 0369, Canton

45122

RECRUITING

Universitaetsklinikum Essen, Essen

45219

RECRUITING

University of Cincinnati Medical Center, Cincinnati

46015

NOT_YET_RECRUITING

Local Institution - 0411, Valencia

46026

NOT_YET_RECRUITING

Local Institution - 0269, Valencia

48121

NOT_YET_RECRUITING

Local Institution - 0400, Ravenna

WITHDRAWN

Local Institution - 0222, Ravenna

48149

NOT_YET_RECRUITING

Local Institution - 0438, Münster

49241

RECRUITING

Pusan National University Hospital, Busan

53127

RECRUITING

Universitätsklinikum Bonn, Bonn

54511

RECRUITING

Centre Hospitalier Régional Universitaire de Nancy - Hôpitaux de Brabois, Vandœuvre-lès-Nancy

58128

RECRUITING

Chonnam National University Hwasun Hospital, Hwasun

59037

RECRUITING

CHU Lille - Institut Coeur Poumon, Lille

59715

COMPLETED

Local Institution - 0308, Bozeman

60415

RECRUITING

Affiliated Oncologists, LLC, Chicago Ridge

64109

RECRUITING

Centre Hospitalier de la Côte Basque, Bayonne

69310

NOT_YET_RECRUITING

Local Institution - 0157, Pierre-Bénite

70124

RECRUITING

Instituto Tumori Giovanni Paolo II, Bari

73730

RECRUITING

Klinikum Esslingen, Esslingen am Neckar

75014

RECRUITING

Hopitaux Universitaires Paris Centre-Hopital Cochin, Paris

75248

NOT_YET_RECRUITING

Local Institution - 0095, Paris

75701

RECRUITING

The University of Texas Health Science Center at Tyler dba UT Health East Texas HOPE Cancer Center, Tyler

76000

NOT_YET_RECRUITING

Local Institution - 0168, Querétaro City

77030

RECRUITING

University of Texas MD Anderson Cancer Center, Houston

78250

NOT_YET_RECRUITING

Local Institution - 0169, San Luis Potosí City

78550

WITHDRAWN

Local Institution - 0305, Harlingen

80131

RECRUITING

A.O.R.N. Ospedale dei Colli - Monaldi V., Naples

NOT_YET_RECRUITING

Local Institution - 0049, Naples

81377

RECRUITING

Klinikum der Ludwig-Maximilians-Universitaet Muenchen, München

82131

RECRUITING

Asklepios Klinik Gauting GmbH, Gauting

83100

RECRUITING

Centre Hospitalier intercommunal de Toulon La Seyne sur Mer, Toulon

83301

RECRUITING

Chang Gung Memorial Hospital at Kaohsiung, Kaohsiung Niao Sung Dist

84112

NOT_YET_RECRUITING

Local Institution - 0302, Salt Lake City

85723

RECRUITING

Southern Arizona VA Health Care System, Tucson

85796

NOT_YET_RECRUITING

Local Institution - 0260, Bydgoszcz

87108

RECRUITING

New Mexico VA Healthcare System, Albuquerque

87439

NOT_YET_RECRUITING

Local Institution - 0287, Kempten (Allgäu)

89081

NOT_YET_RECRUITING

Local Institution - 0439, Ulm

89502

RECRUITING

Renown Regional Medical Center, Reno

90404

WITHDRAWN

Local Institution - 0112, Los Angeles

RECRUITING

UCLA Hematology/Oncology - Santa Monica, Santa Monica

94115

RECRUITING

San Francisco Oncology Associates, San Francisco

95817

RECRUITING

University of California Davis (UC Davis) Comprehensive Cancer Center, Sacramento

100142

RECRUITING

Beijing Cancer hospital, Beijing

100337

RECRUITING

Spitalul Municipal Schuller Ploiești, Ploieşti

110029

RECRUITING

All India Institute of Medical Sciences, New Delhi

NOT_YET_RECRUITING

Local Institution - 0448, New Delhi

110042

RECRUITING

Liaoning Cancer Hospital, Shenyang

110085

RECRUITING

Rajiv Gandhi Cancer Institute And Research Centre, New Delhi

110131

NOT_YET_RECRUITING

Local Institution - 0418, Bogotá

150081

RECRUITING

Harbin Medical University Cancer Hospital, Harbin

200001

NOT_YET_RECRUITING

Local Institution - 0417, Valledupar

200030

RECRUITING

Shanghai Chest Hospital, Shanghai

RECRUITING

Shanghai Chest Hospital, Shanghai

200032

RECRUITING

Zhongshan Hospital,Fudan University, Shanghai

200542

RECRUITING

"Centrul de Oncologie Sfântul Nectarie", Craiova

223300

RECRUITING

First Huai'an Hospital Affiliated to Nanjing Medical University, Huai'an

230031

NOT_YET_RECRUITING

Local Institution - 0182, Hefei

250117

RECRUITING

Shandong Cancer Hospital, Jinan

300060

RECRUITING

Tianjin Medical University Cancer Institute & Hospital, Tianjin

310003

RECRUITING

The first Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou

310016

RECRUITING

Sir Run Run Shaw Hospital of Zhejiang University School of Medicine, Hangzhou

310022

RECRUITING

Zhejiang Cancer Hospital, Hangzhou

317000

RECRUITING

Taizhou Hospital of Zhejiang Province, Linhai

330209

RECRUITING

The First affiliated hospital of Nanchang University (Xianghu campus), Nanchang

350014

RECRUITING

Fujian Cancer Hospital, Fuzhou

400012

NOT_YET_RECRUITING

Local Institution - 0336, Mumbai

400015

RECRUITING

Institutul Oncologic Cluj, Cluj-Napoca

400030

RECRUITING

Chongqing University Cancer Hospital, Chongqing

404000

RECRUITING

Chongqing Three Gorges Central Hospital, Wanzhou

407280

RECRUITING

SC Radiotherapy Center Cluj SRL, Florești

410013

RECRUITING

Hunan Cancer Hospital, Changsha

430079

WITHDRAWN

Local Institution - 0235, Wuhan

450000

COMPLETED

Local Institution - 0237, Zhengzhou

453100

NOT_YET_RECRUITING

Local Institution - 0420, Xinxiang

500003

RECRUITING

Yashoda Hospital, Secunderabad

510080

RECRUITING

The First Affiliated Hospital, Sun Yat-sen University, Guangzhou

510120

RECRUITING

Guangdong Provincial People's Hospital, Guangzhou

510140

RECRUITING

The First Affiliated Hospital of Guangzhou Medical University, Guangzhou

516001

RECRUITING

Huizhou Central People's Hospital, Huizhou

530201

RECRUITING

Guangxi Medical University Affiliated Tumor Hospital, Nanning

545006

RECRUITING

Liuzhou People's Hospital, Liuzhou

560017

NOT_YET_RECRUITING

Local Institution - 0333, Bengaluru

610041

RECRUITING

Sichuan Cancer hospital, Chengdu

641000

RECRUITING

The Second People's Hospital of Neijiang, Neijiang

660001

NOT_YET_RECRUITING

Local Institution - 0416, Pereira

695011

RECRUITING

Regional Cancer Centre - Thiruvananthapuram, Thiruvananthapuram

700483

RECRUITING

Institutul Regional de Oncologie, Iași

710126

RECRUITING

Xi'an International Medical Center Hospital, Xi'an

711103

RECRUITING

Narayana Superspecialty Hospital, Howrah

760032

NOT_YET_RECRUITING

Local Institution - 0442, Santiago de Cali

2418515

RECRUITING

Kanagawa cancer center, Yokohama

2520598

RECRUITING

Oncocentro Apys, Viña del Mar

6738558

RECRUITING

Hyogo Cancer Center, Akashi

7500921

RECRUITING

Fundacion Arturo Lopez Perez (FALP), Santiago

8330032

RECRUITING

Pontificia Universidad Catolica de Chile, Santiago

8420383

RECRUITING

Bradfordhill, Santiago

9810914

RECRUITING

Sendai Kousei Hospital, Sendai

14784400

RECRUITING

Fundação Pio XII - Hospital de Câncer de Barretos, Barretos

60810180

RECRUITING

Pronutrir, Fortaleza

39401-7233

RECRUITING

Hattiesburg Clinic Hematology/Oncology, Hattiesburg

07503

RECRUITING

St. Joseph's Regional Medical Center, Paterson

79606-5208

RECRUITING

Texas Oncology - West Texas, Abilene

C1426ANZ

RECRUITING

Instituto Alexander Fleming, Ciudad Autónoma de Buenos Aires

C1199ABB

RECRUITING

Hospital Italiano de Buenos Aires, ABB

X5800AEV

RECRUITING

Instituto Médico Río Cuarto, Río Cuarto

S2000DSV

RECRUITING

Sanatorio Parque, Rosario

X5000HWE

RECRUITING

Instituto Oncológico de Córdoba, Córdoba

30110-022

RECRUITING

Cetus Oncologia - Unidade Belo Horizonte, Belo Horizonte

66063-495

NOT_YET_RECRUITING

Local Institution - 0375, Belém

59075-740

RECRUITING

Liga Norte Riograndense Contra o Câncer, Natal

90035-903

RECRUITING

Hospital de Clinicas de Porto Alegre, Porto Alegre

90610-000

RECRUITING

Hospital São Lucas da PUCRS, Porto Alegre

88301-220

RECRUITING

Clínica de Neoplasias Litoral, Itajaí

17033-490

RECRUITING

NAIC - Instituto do Câncer, Bauru

09541-270

RECRUITING

Centro de Oncologia - CEON+ - Unidade São Caetano do Sul, São Caetano do Sul

20231-050

RECRUITING

Instituto Nacional de Câncer - INCA, Rio de Janeiro

01246-000

RECRUITING

Icesp - Instituto Do Câncer Do Estado de São Paulo, São Paulo

030000

RECRUITING

Shanxi Cancer Hospital, Taiyuan

09116

RECRUITING

Klinikum Chemnitz, Chemnitz

400 057

RECRUITING

Mumbai Oncocare Centre Vile Parle, Mumbai

D08 E9P6

RECRUITING

St. James's Hospital, Dublin

D18 AK68

NOT_YET_RECRUITING

Local Institution - 0028, Dublin

D24 NR0A

RECRUITING

Tallaght University Hospital, Dublin

D9

WITHDRAWN

Local Institution - 0027, Dublin

00144

NOT_YET_RECRUITING

Local Institution - 0250, Rome

277-8577

NOT_YET_RECRUITING

Local Institution - 0312, Kashiwa

807-8556

RECRUITING

University of Occupational and Enviromental Health, Kitakyushu

830-0011

RECRUITING

Kurume University Hospital, Kurume

720-0001

RECRUITING

Chugoku Central Hospital, Fukuyama-shi

003-0804

RECRUITING

National Hospital Organization Hokkaido Cancer Center, Sapporo

236-0051

RECRUITING

Kanagawa Cardiovascular and Respiratory Center, Yokohama

783-8505

RECRUITING

Kochi Medical School Hospital, Nankoku

634-0813

RECRUITING

Nara Medical University Hospital, Kashihara

951-8566

RECRUITING

Niigata Cancer Center Hospital, Niigata

710-8602

RECRUITING

Kurashiki Central Hospital, Kurashiki

573-1191

RECRUITING

Kansai Medical University Hospital, Hirakata

589-8511

RECRUITING

Kindai University Hospital- Osakasayama Campus, Ōsaka-sayama

350-1298

RECRUITING

Saitama Medical University International Medical Center, Hidaka

431-3192

RECRUITING

Hamamatsu University Hospital, Hamamatsu

411-8777

RECRUITING

Shizuoka Cancer Center, Nagaizumi-cho,Sunto-gun

135-8550

RECRUITING

The Cancer Institute Hospital of JFCR, Koto

960-1295

RECRUITING

Fukushima Medical University, Fukushima

541-8567

RECRUITING

Osaka International Cancer Institute, Osaka

06700

NOT_YET_RECRUITING

Local Institution - 0172, México

3844 DG

WITHDRAWN

Local Institution - 0030, Harderwijk

6419 PC

RECRUITING

Atrium-Orbis - Zuyderland Medisch Centrum Heerlen, Heerlen

5223 GZ

WITHDRAWN

Local Institution - 0196, 's-Hertogenbosch

8025 AB

WITHDRAWN

Local Institution - 0195, Zwolle

2333 ZA

RECRUITING

Leids Universitair Medisch Centrum, Leiden

2512 VA

WITHDRAWN

Local Institution - 0315, The Hague

6815 AD

NOT_YET_RECRUITING

Local Institution - 0033, Arnhem

9700 RB

WITHDRAWN

Local Institution - 0032, Groningen

62-500

NOT_YET_RECRUITING

Local Institution - 0255, Konin

60-192

NOT_YET_RECRUITING

Local Institution - 0256, Poznan

60-693

NOT_YET_RECRUITING

Local Institution - 0261, Poznan

04-125

NOT_YET_RECRUITING

Local Institution - 0259, Warsaw

75-581

NOT_YET_RECRUITING

Local Institution - 0257, Koszalin

82-550

NOT_YET_RECRUITING

Local Institution - 0258, Prabuty

93-338

NOT_YET_RECRUITING

Local Institution - 0254, Lodz

1099-023

NOT_YET_RECRUITING

Local Institution - 0402, Lisbon

4200-072

RECRUITING

Instituto Português de Oncologia do Porto Francisco Gentil, EPE, Porto

4200-319

NOT_YET_RECRUITING

Local Institution - 0401, Porto

013812

RECRUITING

SC Memorial Healthcare International SRL, Bucharest

022338

RECRUITING

Institutul Oncologic Bucuresti, Bucharest

0181

NOT_YET_RECRUITING

Local Institution - 0432, Pretoria

03722

RECRUITING

Severance Hospital, Yonsei University Health System, Seoul

05505

RECRUITING

Asan Medical Center, Seoul

06351

RECRUITING

Samsung Medical Center, Seoul

08035

RECRUITING

Hospital Universitari Vall d'Hebron, Barcelona

08041

RECRUITING

Hospital de la Santa Creu i Sant Pau, Barcelona

08908

NOT_YET_RECRUITING

Local Institution - 0267, L'Hospitalet de Llobregat

07198

RECRUITING

Hospital Son Llàtzer, Palma

01140

NOT_YET_RECRUITING

Local Institution - 0361, Adana

01370

NOT_YET_RECRUITING

Local Institution - 0365, Adana

06230

NOT_YET_RECRUITING

Local Institution - 0383, Ankara

06800

NOT_YET_RECRUITING

Local Institution - 0362, Ankara

EX2 5DW

WITHDRAWN

Local Institution - 0441, Exeter

DD1 9SY

RECRUITING

Ninewells Hospital and Medical School, Dundee

FK5 4WR

RECRUITING

Forth Valley Royal Hospital, Larbert

g12OYN

NOT_YET_RECRUITING

Local Institution - 0189, Glasgow

SW3 6JJ

WITHDRAWN

Local Institution - 0021, London

LE1 5WW

NOT_YET_RECRUITING

Local Institution - 0026, Leicester

EC1A 7BE

RECRUITING

St Bartholomew's Hospital, London

SE1 9RT

NOT_YET_RECRUITING

Local Institution - 0001, London

M20 4BX

WITHDRAWN

Local Institution - 0020, Manchester

CH63 4JY

WITHDRAWN

Local Institution - 0024, Metropolitan Borough of Wirral

RG1 5AN

NOT_YET_RECRUITING

Local Institution - 0463, Reading

Sponsors
All Listed Sponsors
lead

Bristol-Myers Squibb

INDUSTRY