NCT06560645 - A Study of PRT7732, an Oral SMARCA2 Degrader, in Patients With Advanced or Metastatic Solid Tumors With a SMARCA4 Mutation | Biotech Hunter

Enrollment

104

Participants

Timeline

Start Date

November 4, 2024

Primary Completion Date

October 31, 2026

Study Completion Date

April 30, 2027

Conditions

Advanced Solid TumorMetastatic Solid TumorNon-small Cell Lung CarcinomaSMARCA4 MutationEsophageal AdenocarcinomaEsophageal Squamous Cell CarcinomaGastric AdenocarcinomaGastric Squamous Cell CarcinomaGastroesophageal Junction AdenocarcinomaGastroesophageal Junction Squamous Cell Carcinoma

Interventions

DRUG

PRT7732

PRT7732 capsules will be self-administered once daily at the dose-level assigned

Trial Locations (28)

2031

RECRUITING

Scientia Clinical Research Ltd, Randwick

2576

RECRUITING

Southern Highlands Cancer Centre, Bowral

2640

RECRUITING

Border Medical Oncology Research Unit, Albury

3168

RECRUITING

Monash Health, Clayton

6009

RECRUITING

Linear Clinical Research Ltd, Nedlands

10029

RECRUITING

Icahn School of Medicine at Mount Sinai, New York

10065

RECRUITING

Memorial Sloan Kettering Cancer Center - Main Campus, New York

10408

RECRUITING

National Cancer Center, Goyang-si

19104

RECRUITING

Hospital of the University of Pennsylvania, Philadelphia

22903

RECRUITING

University of Virginia Comprehensive Cancer Center, Charlottesville

27514

RECRUITING

UNC Hospitals, The University of North Carolina Chapel Hill, Chapel Hill

28040

RECRUITING

Start Madrid-FJD, Hospital Universitario Fundacion Jimenez Diaz-Servicio de Oncologia, Madrid

28050

RECRUITING

Hospital Universitario HM Sanchinarro, Madrid

37203

RECRUITING

SCRI Oncology Partners, Nashville

44106

RECRUITING

University Hospitals Cleveland Medical Center, Cleveland

48202

RECRUITING

Brigitte Harris Cancer Pavilion, Detroit

50937

RECRUITING

University Clinic Cologne, Clinic for Internal Medicine, Cologne

77030

RECRUITING

The University of Texas MD Anderson Cancer Center, Houston

94158

RECRUITING

UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco

97239

RECRUITING

Oregon Health & Science University, Portland

01307

RECRUITING

Technische Universitat Dresden, Medizinlsche Fakultat Carl Gustav Carus Nationales Centrum fur Tumorerkrankungen Dresden, Early Clinical Trial Unit (NCT/UCC ECTU), Dresden

589-8511

RECRUITING

Kindai University Hospital, Sayama

565-0871

RECRUITING

The Univerity of Osaka Hospital, Suita

104-0045

RECRUITING

National Cancer Center Hospital, Chuo Ku

135-8550

RECRUITING

Cancer Institute Hospital of JFCR, Koto-ku

03722

RECRUITING

Severance Hospital, Yonsei University Health System, Seoul

06351

RECRUITING

Samsung Medical Center, Seoul

08035

RECRUITING

Hospital Universitario Vall d'Hebron, Barcelona