Restrictive Versus Liberal Thresholds for RBC Transfusion in ECMO

NARecruitingINTERVENTIONAL
Enrollment

526

Participants

Timeline

Start Date

November 26, 2024

Primary Completion Date

October 1, 2028

Study Completion Date

October 1, 2029

Conditions
TransfusionRed Blood CellExtracorporeal Membrane OxygenationAnemiaECMO
Interventions
OTHER

Red Blood Cell transfusion

When the appropriate Hb threshold is reached, patients in each group will have one unit of RBC administered at a time. Within 3 hours after the transfusion, a repeat Hb concentration will be measured. Each group will only be transfused when their Hb level falls below the transfusion threshold. In case of a outlier measurement, clinicians are advised to repeat the measurement. The RBC transfusion must take place within 4 hours when the Hb trigger was measured.

Trial Locations (12)

1070

RECRUITING

Hôpital Erasme Brussels, Brussels

3000

RECRUITING

KU Leuven, medical IC, Leuven

RECRUITING

KU Leuven, surgical IC, Leuven

6000

RECRUITING

CHU Charleroi, Charleroi

7512 KZ

RECRUITING

Medisch Spectrum Twente (MST), Enschede

6229 HX

RECRUITING

Maastricht Universitair Medisch Centrum+ (MUMC+), Maastricht

1105 AZ

RECRUITING

Amsterdam UMC, location AMC, Amsterdam

9713 GZ

RECRUITING

Universitair Medisch Centrum Groningen (UMCG), Groningen

2333 ZA

NOT_YET_RECRUITING

Leids Universitair Medisch Centrum (LUMC), Leiden

3015 GD

NOT_YET_RECRUITING

Erasmus MC, Rotterdam

3435 CM

RECRUITING

St. Antonius Ziekenhuis, Nieuwegein

171 76

NOT_YET_RECRUITING

Karolinska Universtiy Hospital, Stockholm

All Listed Sponsors
collaborator

ZonMw: The Netherlands Organisation for Health Research and Development

OTHER

lead

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

OTHER