Ketoconazole Contributes to Cryptorchidism Outcome Via Modulating Macrophage Trem2

NARecruitingINTERVENTIONAL
Enrollment

10

Participants

Timeline

Start Date

February 3, 2024

Primary Completion Date

December 1, 2024

Study Completion Date

December 31, 2024

Conditions
Cryptorchidism
Interventions
DRUG

Ketoconazole

A fetal developmental stage is precisely determined. Then, fetal tissues are extracted for in vitro cultivation. Intact aborted fetal testicular tissues are cultured in a medium containing 10-6 mol/L ketoconazole, which is the injectable solution powder. Ketoconazole is administered starting on the first day and then every other day, for a total of 7 times over the 14-day in vitro culture period.

DRUG

Luteinizing Hormone

A fetal developmental stage is precisely determined. Then, fetal tissues are extracted for in vitro cultivation. Intact aborted fetal testicular tissues are cultured in a medium containing 1 IU/mL luteinizing hormone, which is the injectable solution powder. Luteinizing hormone is administered starting on the first day and then every other day, for a total of 7 times over the 14-day in vitro culture period.

Trial Locations (1)

226001

RECRUITING

Affiliated hospital of nantong university, Nantong

All Listed Sponsors
lead

Affiliated Hospital of Nantong University

OTHER