Weight Cycling on Hyperandrogenemia and Insulin Resistance in Polycystic Ovary Syndrome

NANot yet recruitingINTERVENTIONAL
Enrollment

425

Participants

Timeline

Start Date

August 15, 2024

Primary Completion Date

August 15, 2025

Study Completion Date

August 15, 2026

Conditions
Polycystic Ovary Syndrome
Interventions
OTHER

Adjusting dietary structure + exercise + behavioral intervention

Adjusting to a healthy diet involves consuming low GI and low-fat foods, avoiding sugary drinks, increasing dietary fiber intake, reducing saturated fat while increasing omega-3 unsaturated fat intake, and limiting trans fat consumption. A weight loss program includes a high-protein diet, exercise, and behavioral intervention with daily total energy needs calculated based on ideal body weight (kg) x 15-20 kcal/kg/d; developing a daily meal plan with regular protein supplementation; limiting salt intake to ≤5 g/d; ensuring adequate water consumption at 2-3L/d; aiming for a dietary fiber intake of 25-30g/d; recommending micronutrient supplementation as needed; maintaining daily aerobic exercise (40 minutes at 70-80% HRmax) along with resistance training (20 minutes); establishing an early bedtime before 11pm and an early wake-up time.

Trial Locations (1)

100730

Peking Union Medical College Hospital, Beijing

All Listed Sponsors
lead

Peking Union Medical College Hospital

OTHER

NCT06545721 - Weight Cycling on Hyperandrogenemia and Insulin Resistance in Polycystic Ovary Syndrome | Biotech Hunter | Biotech Hunter