Coated or Chewable Aspirin and a Hybrid Strategy to Mitigate Adverse Effects of Air Pollution in Stable Atherosclerotic Disease

NARecruitingINTERVENTIONAL
Enrollment

3,000

Participants

Timeline

Start Date

March 6, 2024

Primary Completion Date

March 30, 2026

Study Completion Date

March 30, 2027

Conditions
Atherosclerotic Cardiovascular DiseaseCoronary Artery DiseaseIschemic Heart DiseaseIschemic StrokePeripheral Arterial DiseaseCarotid Artery StenosisCarotid Atherosclerosis
Interventions
DRUG

Enteric-coated aspirin

Enteric-coated aspirin tablet 81 mg, once daily

DRUG

Plain aspirin

Plain aspirin tablet 81 mg, once daily

OTHER

Hybrid strategy

"A hybrid strategy composed from:~* A one-page educational flashcard~* Alerting patients on highly polluted days via text message~* Encouraging patients to stay at home or minimizing outdoor activity on highly polluted days~* Encouraging patients via text message to wear KN-95 facemasks (provided by the investigators of this study) during outdoors time on highly polluted days~* Encouraging patients to consume citrus fruits during highly polluted days"

Trial Locations (1)

1995614331

RECRUITING

Rajaie Cardiovascular Medical and Research Center, Tehran

All Listed Sponsors
collaborator

Brigham and Women's Hospital

OTHER

lead

Rajaie Cardiovascular Medical and Research Center

OTHER