Phase I Study Evaluating Tolerability, Safety, Pharmacokinetics, and Efficacy of Combined ONO-4059 and R-MPV Therapy for PCNSL

PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

20

Participants

Timeline

Start Date

May 17, 2024

Primary Completion Date

April 28, 2028

Study Completion Date

August 31, 2028

Conditions
Primary Central Nervous System Lymphoma
Interventions
DRUG

ONO-4059

Specified dose, once daily

DRUG

Rituximab

Specified dose on specified days

DRUG

Methotrexate

Specified dose on specified days

DRUG

Procarbazine

Specified dose on specified days

DRUG

Vincristine

Specified dose on specified days

Trial Locations (44)

Unknown

Aichi Cancer Center, Nagoya

Nagoya City University Hospital, Nagoya

Akita University Hospital, Akita

Juntendo University Urayasu Hospital, Urayasu-shi

Fukuoka University Hospital, Fukuoka

Kyushu University Hospital, Fukuoka

Hospital of the University of Occupational and Environmental Health,Japan, Kitakyushu-shi

Kurume University Hospital, Kurume-shi

Fukushima Medical University Hospital, Fukushima

Gifu University Hospital (Tokai National Higher Education and Research System), Gifu

Gunma University Hospital, Maebashi

Sapporo Medical University Hospital, Sapporo

Kobe City Medical Center General Hospital, Kobe

Hyogo Medical University Hospital, Nishinomiya-shi

University of Tsukuba Hospital, Tsukuba

Kanazawa Medical University Hospital, Kahoku-gun

Kagawa University Hospital, Kita-gun

St. Marianna University Hospital, Kawasaki-shi

Yokohama City University Hospital, Yokohama

Kochi Medical School Hospital, Nankoku-shi

University of Miyazaki Hospital, Miyazaki

NAGASAKI University Hospital, Nagasaki

Kindai University Nara Hospital, Ikoma-shi

Nara Medical University, Kashihara-shi

Niigata University Medical & Dental Hospital, Niigata

Oita University Hospital, Yufu-shi

Kurashiki Central Hospital, Kurashiki-shi

Osaka International Cancer Institute, Osaka

Kindai University Hospital, Osakasayama-shi

Osaka University Hospital, Suita-shi

Saga University Hospital, Saga

Saitama Medical Center, Kawagoe-shi

Shizuoka Cancer Center, Sunto-gun

Dokkyo Medical University Hospital, Shimotsuga-gun

Institute of Science Tokyo Hospital, Bunkyo-ku

The Cancer Institute Hospital of JFCR, Koto-ku

National Hospital Organization Disaster Medical Center, Midorichō

The Jikei University Hospital, Minato-ku

Toranomon Hospital, Minato-ku

Tokyo Medical University Hospital, Shinjuku-ku

Tokyo Women's Medical University Hospital, Shinjuku-ku

Toyama University Hospital, Toyama

Yamaguchi University Hospital, Ube-shi

University of Yamanashi Hospital, Chuo-shi

Sponsors
All Listed Sponsors
lead

Ono Pharmaceutical Co. Ltd

INDUSTRY