2,500
Participants
Start Date
April 24, 2024
Primary Completion Date
April 30, 2027
Study Completion Date
April 30, 2028
De-escalation VS No De-escalation
"No de-escalation group: continue to receive the same antibiotic that was started initially (as long as it is confirmed to be effective based on the blood culture sensitivity result). De-escalation is only allowed within 7 days if patient is being discharged from hospital.~De-escalation group: switched to narrower spectrum antibiotic (based on spectrum scale specified in protocol)."
Oral beta-lactams VS non beta-lactams
"Beta-lactam antibiotic: This can be, but not limited to, amoxicillin, amoxicillin-clavulanate, cephalexin, cefadroxil, or cefixime.~Non beta-lactam antibiotic: This can be ciprofloxacin, moxifloxacin, levofloxacin or trimethoprim-sulfamethoxazole."
Central vascular catheter retention VS Central vascular catheter replacement
"Central vascular catheter replacement: the catheter will be changed by the treating team as soon as possible and within a maximum of 72 hours from blood culture finalization~Central vascular catheter retention: the catheter will not be changed and will be retained until it is non functional or no longer needed."
Cephalosporin VS Carbapenem for low risk AmpC organisms
"Cephalosporin (ceftriaxone) at standard doses~Carbapenem (Meropenem or Ertapenem) at standard doses"
Routine follow-up blood culture VS No routine follow-up blood culture
"Routine follow-up blood culture: routine repeat blood collection 4 days from the index blood collection with positive bacteria.~No follow-up blood culture: no routine repeat blood collection 4 days from the index blood collection with positive bacteria"
RECRUITING
St George Hospital, Kogarah
RECRUITING
John Hunter Hospital, New Lambton
RECRUITING
Redcliffe Hospital, Redcliffe
RECRUITING
Sunshine Coast University Hospital, Sunshine Coast
RECRUITING
Monash Medical Center, Clayton
RECRUITING
Fiona Stanley Hospital, Murdoch
RECRUITING
St John of God, Murdoch
RECRUITING
Foothills Hospital, Calgary
RECRUITING
Peter Lougheed Centre, Calgary
RECRUITING
Rockyview General Hospital, Calgary
RECRUITING
South Health Campus, Calgary
RECRUITING
University of Alberta, Edmonton
RECRUITING
Surrey Memorial Hospital, Surrey
RECRUITING
Vancouver General Hospital, Vancouver
RECRUITING
Grace Hospital, Winnipeg
RECRUITING
Health Sciences Centre, Winnipeg
ACTIVE_NOT_RECRUITING
St. Boniface Hospital, Winnipeg
NOT_YET_RECRUITING
Dr. Everett Chalmers Regional Hospital, Fredericton
RECRUITING
Eastern Regional Health Authority, St. John's
NOT_YET_RECRUITING
Trillium Health Partners - Mississauga Hospital, Mississauga
NOT_YET_RECRUITING
Humber River Health system, North York
RECRUITING
North York General Hospital, North York
RECRUITING
The Ottawa Hospital, Ottawa
RECRUITING
Niagara Health System, St. Catharines
RECRUITING
Michael Garron Hospital, Toronto
RECRUITING
Mount Sinai Hospital, Toronto
RECRUITING
St. Joseph's Health Centre, Toronto
RECRUITING
University Health Network, Toronto
NOT_YET_RECRUITING
CHU de Québec - Université Laval, Laval
RECRUITING
Hôpital de la Cité de la Santé, Laval
RECRUITING
Montreal General Hospital- McGill, Montreal
RECRUITING
Royal Victoria Hospital- McGill, Montreal
RECRUITING
Université de Sherbrooke, Sherbrooke
RECRUITING
Universidad de La Sabana, Chía
RECRUITING
Sheba Medical Center, Ramat Gan
RECRUITING
Sunnybrook Health Sciences Centre, Toronto
Canadian Institutes of Health Research (CIHR)
OTHER_GOV
Sunnybrook Health Sciences Centre
OTHER