Ketogenic Diet in MASLD-related cACLD

NANot yet recruitingINTERVENTIONAL
Enrollment

50

Participants

Timeline

Start Date

November 30, 2024

Primary Completion Date

November 30, 2026

Study Completion Date

November 30, 2026

Conditions
Steatohepatitis, NonalcoholicSteatosis of LiverCirrhosis, Liver
Interventions
DIETARY_SUPPLEMENT

Mediterranean diet

This equilibrated diet has a caloric value 10% below the total metabolic expenditure of each individual. The total metabolic expenditure is calculated from the basal metabolic expenditure (based on the formula FAO/WHO/UN) multiplied by the coefficient of activity, which is calculated according to the physical activity of each participant. The calories provide to this group range between 1,400 and 1,800 kcal/day. The ration of macronutrients provided is 45-55 % arbohydrates,15-25 % proteins, and 25-35 % fat, in addition to a recommended intake of 20-40 g/day of fiber in the form of vegetables and fruits.

DIETARY_SUPPLEMENT

Very Low Ketogenic Diet

The VLCKD ketogenic protocol entails: a caloric intake \< 800 calories, a protein intake calculated based on individual needs: 1.2 + 0.2 g/kg/ideal body weight, low carbohydrate content (approximately 45-55 g of carbohydrates per day), and low lipids (10-15g/day). Vitamins and minerals, Unlimited vegetables.

Trial Locations (1)

Unknown

Section of Gastroenterology, PROMISE, University of Palermo, Palermo

All Listed Sponsors
lead

University of Palermo

OTHER

NCT06537466 - Ketogenic Diet in MASLD-related cACLD | Biotech Hunter | Biotech Hunter