A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Tirzepatide in People With Type 2 Diabetes Treated With Metformin, SGLT2 Inhibitor or Both

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

1,023

Participants

Timeline

Start Date

November 5, 2024

Primary Completion Date

June 2, 2026

Study Completion Date

July 14, 2026

Conditions
Diabetes Mellitus, Type 2
Interventions
DRUG

Cagrilintide

Participants will receive once-weekly cagrilintide subcutaneously.

DRUG

Semaglutide

Participants will receive once-weekly semaglutide subcutaneously.

DRUG

Tirzepatide

Participants will receive once-weekly tirzepatide subcutaneously.

Trial Locations (144)

333

Chang Gung Memorial Hospital Linkou, Taoyuan

Chang Gung Memorial Hospital, Linkou, Taoyuan District

404

China Medical University Hospital, Taichung

407

Taichung Veterans General Hospital, Taichung

704

National Cheng Kung University Hospital, Tainan City

807

Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City

Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaoshiung

1036

QUALICLINIC Egészségügyi Szolgáltató és Kutatásszervező Kft, Budapest

Óbudai Egészségügyi Centrum, Budapest

1042

Szőcs Depot Egészségügyi Szolgáltató Kft., Budapest

1083

Semmelweis Egyetem, Budapest

1089

ClinDiab Egészségügyi Szolgáltató és Kereskedelmi Kft., Budapest

1102

PVN Kutato Kft., Budapest

1132

MED-TIMA Kft., Budapest

2065

Austrials, St Leonards

Momentum Clinical Research, St Leonards

2148

Roger Chih Yu Chen, Sydney

2291

Hunter Diabetes Centre, Merewether

2617

Paratus Clinical, Bruce

2900

Komáromi Selye János Kórház, Komárom

4000

Centro de Investigaciones Médicas Tucumán, San Miguel de Tucuimán

4006

Paratus Clinical, Herston

4814

Townsville University Hospital, Douglas

6300

Fundación CESIM, Santa Rosa

6725

Szegedi Tudomanyegyetem St Györgyi Albert Klinikai Központ, Szeged

10676

Evangelismos Hospital, Athens

11527

"Laiko General Hospital of Athens", Goudi/Athens

11528

Alexandra General Hospital, Therapeutic Clinic, Athens

12203

Albany Medical College, Albany

17562

Iatriko Athinon 'Palaiou Falirou', Athens

19464

Circuit Clinical - PMSI, Pottstown

20010

FEME Medical LLC, Washington D.C.

22607

Wendisch/Dahl Hamburg (DZHW), Hamburg

23606

TPMG Clinical Research, Newport News

28557

Carteret Medical Group, Morehead City

28625

Piedmont Healthcare/Research, Statesville

30214

Javara Inc. / Privia Medical Group Georgia LLC, Fayetteville

31008

Clinica Universitaria de Navarra, Pamplona

31096

Rambam MC - Diabetes and obesity center of excellence, Haifa

32545

Herz- und Diabeteszentrum NRW - Bad Oeynhausen, Bad Oeynhausen

32763

Optimal Research Sites, Orange City

33012

AGA Clinical Trial, Hialeah

33027

South Broward Research LLC, Miramar

33144

Clinical Trial Services Corp, Miami

33155

Bioclinical Research Alliance, Miami

33165

New Horizon Research Center, Miami

33761

Tampa Bay Medical Research, Clearwater

34761

West Orange Endocrinology, Ocoee

35124

Cahaba Research, Pelham

37203

Clinical Research Associates, Nashville

37660

Holston Medical Group, Kingsport

41003

Clínica Nuevas Tecnologías en Diabetes y Endocrinología, Seville

45147

Universitätsklinikum Essen - Klinik für Endokrinologie, Diabetologie und Stoffwechsel, Essen

45355

Praxis am Markt Dr. Becker, Essen

45500

University General Hospital of Ioannina,Internal Medicine, Ioannina

47003

Hospital Clínico de Valladolid, Valladolid

48153

MedicalCenter am Clemenshospital - Schwerpunktpraxis für Diabetologie und Ernährungsmedizin, Münster

49100

Rabin MC Beilinson - Endo unit, Petah Tikva

50266

Iowa Diabetes & Endo Res Ctr, West Des Moines

52621

Sheba MC - Endocrinology Clinic, Tel Litwinsky

54635

General Hospital of Thessaloniki 'G. Gennimatas, Thessaloniki

54642

'Ippokrateio' General Hospital of Thessaloniki, Thessaloniki

55423

AES Minneapolis DRS, Richfield

58100

Wolfson MC - Diabetes Clinic, Holon

58104

Lillestol Research LLC, Fargo

60031

Clinical Invest Special_Gurnee, Gurnee

71409

Venizeleio Pananeio, Heraklion

72211

Woodland Int. Research Group, Little Rock

73072

Triad Research Institute, Norman

75390

UT Southwestern Medical Center - Lingvay, Dallas

76401

Privia Health Javara Clin Res., Stephenville

77040

Juno Research, LLC_Houston, Houston

77061

Discovery MM Services - Houston - Broadway Street, Houston

77079

PlanIt Research, PLLC, Houston

78028

Sante Clinical Research, Kerrville

78041

Aeres Clinical Research, Laredo

78503

RGV Endocrine Center, McAllen

78759

Velocity Clin Res Austin, Austin

80906

Optumcare Clinical Trials,LLC-Golden, Colorado Springs

81667

Medicover Neuroendokrinologie MVZ München, München

84109

J.Lewis Research Inc, Salt Lake City

84790

Chrysalis Clinical Research, St. George

85006

Velocity Clinical Research-Phoenix, Phoenix

85712

AES Tucson DRS, Tucson

88239

Zentrum für klinische Studien Allgäu Oberschwaben, Wangen

91120

Hadassah Ein Karam MC - Diabetes Unit, Jerusalem

91405

Velocity Clin Res - Panorama, Van Nuys

91942

Diabetes & Endocrine Specialists - La Mesa, La Mesa

92262

Desert Oasis Healthcare, Palm Springs

94520

John Muir Physicians Network, Concord

110029

All India Institute of Medical Sciences (AIIMS), New Delhi

226002

Udyaan Health Care, Lucknow

302004

SMS Hospital, Jaipur

302006

Diabetes, Thyroid and Endocrine Centre, Jaipur

305001

Jawahar Lal Nehru Govt. Medical College, Ajmer

404328

China Medical University Hospital, Taichung

410147

Diabdana S.R.L., Oradea

430222

CMI Dr Pop Lavinia, Baia Mare

440055

Clinica Korall S.R.L. Satu Mare, Satu Mare

442001

Acharya Vinoba Bhave Rural Hospital, Sawangi Meghe, Wardha, Wardha

500032

AIG Hospitals,Hyderabad, Hyderabad

522001

Endolife Specialty Hospitals, Guntur

540142

Sc Mediab Srl, Târgu Mureş

560054

Ramaiah Memorial Hospital, Bengaluru

700020

IPGME&R and SSKM Hospital, Kolkata

4630945

Clalit sick fund Herzeliya, Herzeliya

6423906

Sourasky MC - Institute of Endocrinology, metabolism and hypertension, Tel Aviv

66606-2806

Cotton-Oneill Diabetes and End, Topeka

68198-3020

Univ of Nebraska Medical CTR, Omaha

02864

Clinical Res Collaborative, Cumberland

02818

Velocity Clin Res Providence, East Greenwich

B1824KAJ

Centro Médico CIMEL, Lanús Este

B7600GNY

Centro de Investigaciones Médicas Clínica de Fracturas y Or, Mar del Plata

C1056ABH

IMOBA, City of Buenos Aires

B2900

Instituto de Investigaciones Clinicas San Nicolás, San Nicolás

80810-040

Centro de Diabetes Curitiba, Curitiba

90430-001

Núcleo de Pesquisa Clínica do Rio Grande do Sul Ltda., Porto Alegre

01228-000

CPQuali Pesquisa Clínica Ltda, São Paulo

V4A 0C1

Hilltop Medical Clinic, Surrey

E1G 1A7

G.A. Research Associates Ltd., Moncton

L6S 0C6

Centricity Research Brampton, Brampton

M9R 4E1

Centricity Research Etobicoke, Etobicoke

N7T 4X3

London Road Diagnostic Clinic and Medical Centre, Sarnia

M6G 1M2

Diabetes Heart Research Centre, Toronto

H7T 2P5

Ctr de rech Clin de Laval, Laval

G6V 0C9

Alpha Recherche Clinique - Clinique de Levis, Lévis

H4N 2W2

Centre Medical Acadie, Montreal

J6X 4P7

Ctr de Med Metab de Lanaudiere, Terrebonne

625 020

Arthur Asirvatham hospital,, Madurai

15-276

Uniwersytecki Szpital Kliniczny w Bialymstoku, Bialystok

15-269

Uniwersytecki Szpital Kliniczny w Bialymstoku, Bialystok

41-516

Diab Serwis Popenda Spółka Jawna, Chorzów

66-400

Specjalistyczny Gabinet Diabetologiczny Rumianowski Radosław, Gorzów Wielkopolski

90-338

Centrum Terapii Wspolczesnej J.M. Jasnorzewska S.K.A., Lodz

10-117

Etyka Osrodek Badan Klinicznych Tomasz Pesta S.K.A., Olsztyn

41-209

Kiepury Clinic MALGORZATA JARNOT SPECJALISTYCZNA PRAKTYKA GINEKOLOGICZNO-POLOZNICZA, Sosnowiec

52-416

Centrum Medyczne Oporow, Wroclaw

41-800

Samodzielny Publiczny Szpital Kliniczny Nr 1 im. Prof. Szyszko, Zabrze

020475

Institutul National De Diabet Nutritie Si Boli Metabolice Prof.Dr.N.Paulescu Bucuresti- Ion Movila, Bucharest

013764

SC Nutrilife SRL, Bucharest

050913

Diabet Med SRL, Bucharest

060013

Sanamed Hospital SRL, Bucharest

04009

Centro Periferico De Especialidades Bola Azul, Almería

08035

Hospital Vall d'Hebron, Barcelona

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Novo Nordisk A/S

INDUSTRY