Methylene Blue for the Treatment of Septic Shock

Methylene Blue 100mg will be diluted in 40ml 5% dextrose solution.The patient will receive Methylene Blue bolus with a dose of 1 mg/kg (Ideal Body Weight) over 30 minutes,followed by 0.25mg/kg/h as a continuous infusion for 6 hours for 5 days or discontinution of norepinephrine or until ICU discharge, whichever occurred first.

An identical volume of 5% dextrose solution from the placebo drug bag will be administered to patients using the same protocol as intervention arm.