A Phase Ⅲ Clinical Study of HLX22 in Combination With Trastuzumab and Chemotherapy for the Treatment of Gastroesophageal Junction and Gastric Cancer

PHASE3RecruitingINTERVENTIONAL
Enrollment

550

Participants

Timeline

Start Date

November 22, 2024

Primary Completion Date

June 1, 2027

Study Completion Date

September 1, 2028

Conditions
Gastroesophageal-junction CancerMonoclonal AntibodyGastric CancerHER2-positive Gastric Cancer
Interventions
DRUG

HLX22

HLX22 15mg/kg Q3w

DRUG

Pembrolizumab

Pembrolizumab 200mg q3w

DRUG

Trastuzumab

Trastuzumab 8 mg/kg loading dose and then 6 mg/kg maintenance thereafter ,Q3W

DRUG

Oxaliplatin

Oxaliplatin 130 mg/m2 ,Q3W

DRUG

Capecitabine

Capecitabine 1000 mg/m2 bid on Days 1-14 ,Q3W

Trial Locations (88)

112

RECRUITING

LLC Todua Clinic, Tbilisi

114

RECRUITING

"Ltd New Hospitals", Tbilisi

RECRUITING

Tbilisi State Medical University and Ingorovka High Medical Technology University Clinic Ltd, Tbilisi

159

RECRUITING

JSV VIAN- Caraps Medline, Tbilisi

186

RECRUITING

Evex Hospitals - Caucasus Medical Center, Tbilisi

2109

RECRUITING

Macquarie University, North Ryde

2250

RECRUITING

Central Coast Local Health District (Gosford and Wyong Hospital), Gosford

2560

RECRUITING

GenesisCare Research, Campbelltown

3065

RECRUITING

St. Vincent Hospital Melbourne, Fitzroy

3940

RECRUITING

Peninsula Health-Frankston hospital, Frankston

4556

RECRUITING

University of the Sunshine Coast Clinical Trials, Sunshine Coast Haematology and Oncology Clinic, Sunshine Coast

15232

RECRUITING

UPMC Hillman Cancer Center, Pittsburgh

18840

RECRUITING

Guthrie Medical Group, PC and Robert Packer Hospital (Guthrie Cancer Center - Sayre), Sayre

26506

RECRUITING

West Virginia University Cancer Institute, Morgantown

33064

RECRUITING

Advanced Research LLC, Deerfield Beach

RECRUITING

Napa Research, Pompano Beach

33322

RECRUITING

BRCR Medical Center, Plantation

33401

RECRUITING

Florida Cancer Specialist - East, West Palm Beach

33705

RECRUITING

Florida Cancer Specialist - North, St. Petersburg

33901

RECRUITING

Florida Cancer Specialist - South, Fort Myers

37232

RECRUITING

Vanderbilt University Medical Center, Nashville

44195

RECRUITING

Cleveland Clinic, Cleveland

50309

RECRUITING

Mission Cancer + Blood (Exigent Network), Des Moines

52242

RECRUITING

Holden Comprehensive Cancer Center - University of Iowa, Iowa City

60611

RECRUITING

Northwestern University, Chicago

63110

RECRUITING

Washington University School of Medicine St. Louis, St Louis

68130

RECRUITING

Nebraska Cancer Specialists, Omaha

77030

RECRUITING

The University of Texas MD Anderson cancer Center, Houston

77598

RECRUITING

Texas Oncology - Gulf Coast (SCRI), Webster

78705

RECRUITING

Texas Oncology Central South (SCRI), Austin

79606

RECRUITING

Texas Oncology - West (SCRI), Abilene

80631

RECRUITING

Banner MD Anderson Cancer Center, Greeley

89169

RECRUITING

Comprehensive Cancer Centers Nevada, Las Vegas

90720

RECRUITING

OPN - Oncology Physician Network (Los Alamitos), Los Alamitos

92801

RECRUITING

Los Angeles Cancer Network, Anaheim

98405

RECRUITING

Northwest Medical Specialties, Tacoma

98502

RECRUITING

American Oncology Network Vista Oncology Division, Olympia

100142

RECRUITING

Beijing Cancer Hospital, Beijing

7560908

RECRUITING

Centro de Oncologia de Precision, Santiago

7630000

RECRUITING

Instituto del Cancer RedSalud Vitacura, Santiago

Sydney

RECRUITING

Concord Repatriation General Hospital, Concord

Unknown

RECRUITING

The Fourth Hospital of Hebei Medical University, Shijiazhuang

RECRUITING

Affiliated Hospital of Youjiang Medical University for Nationalities, Baise City

RECRUITING

Cancer Hospital Chinese Academy of Medical Sciences, Beijing

RECRUITING

Peking Union Medical College Hospital, Beijing

RECRUITING

The First Affiliated Hospital of Bengbu Medical University, Bengbu

RECRUITING

The First Hospital of Jilin University, Changchun

RECRUITING

Hunan Cancer Hospital, Changsha

RECRUITING

Heping Hospital Affiliated to Changzhi Medical College, Changzhi

RECRUITING

Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu

RECRUITING

West China Hospital of Sichuan University, Chengdu

RECRUITING

The First Affiliated Hospital of Chongqing Medical University, Chongqing

RECRUITING

Fujian Cancer Hospital, Fuzhou

RECRUITING

Zhongshan City People's Hospital, Guangdong

RECRUITING

The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou

RECRUITING

Sir Run Run Shaw Hospital (SRRSH), affiliated with the Zhejiang University School of Medicine, Hangzhou

RECRUITING

The First Affiliated Hospital, Zhejiang University School of Medic, Hangzhou

RECRUITING

Harbin Medical University Cancer Hospital, Harbin

RECRUITING

The First Affiliated Hospital of Anhui Medical University, Hefei

RECRUITING

The Second Hospital of Anhui Medical University, Hefei

RECRUITING

Cancer Hospital of Shandong First Medical University, Jinan

RECRUITING

Gansu Provincial Cancer Hospital, Lanzhou

RECRUITING

Gansu Provincial Hospital, Lanzhou

RECRUITING

The First Hospital Of Lanzhou University, Lanzhou

RECRUITING

Liuzhou Workers' Hospital, Liuzhou

RECRUITING

The First Affiliated Hospital of Henan University of Science, Luoyang

RECRUITING

Mianyang Central Hospital, Mianyang

RECRUITING

The First Affiliated Hospital of Nanchang University, Nanchang

RECRUITING

Nanjing Drum Tower Hospital, Nanjing

RECRUITING

The Affiliated Hospital of Qingdao University, Qingdao

RECRUITING

Renji Hospital,Shanghai Jiao Tong University School of Medicine, Shanghai

RECRUITING

The Central Hospital of Shaoyang, Shaoyang

RECRUITING

Liaoning Medical University Cancer Institute & Hospital, Shenyang

RECRUITING

Shanxi Cancer Hospital, Taiyuan

RECRUITING

Tianjin Medical University Cancer Institute & Hospital, Tianjin

RECRUITING

Cancer Hospital Affiliated to Xinjiang Medical University, Ürümqi

RECRUITING

The First Affiliated Hospital of Xiamen University, Xiamen

RECRUITING

Qinghai University Affiliated Hospital, Xining

RECRUITING

Xuzhou Central Hospital, Xuzhou

RECRUITING

Yichang Central People's Hospital, Yichang

RECRUITING

General Hospital of Ningxia Medical University, Yinchuan

RECRUITING

Henan Cancer Hospital, Zhengzhou

RECRUITING

The First Affiliated Hospital of Zhengzhou University, Zhengzhou

RECRUITING

Hiroshima City Hiroshima Citizens Hospital, Hiroshima

RECRUITING

Ishikawa Prefectural Central Hospital, Kanazawa

RECRUITING

Osaki Citizen Hospital, Osaki-shi

RECRUITING

Saitama Cancer Center, Saitama

RECRUITING

Keiyukai Sapporo Hospital, Sapporo

All Listed Sponsors
collaborator

Henlius USA

UNKNOWN

lead

Shanghai Henlius Biotech

INDUSTRY