The MUSE Study for Menopausal Arthralgia

PHASE2/PHASE3RecruitingINTERVENTIONAL
Enrollment

100

Participants

Timeline

Start Date

August 1, 2024

Primary Completion Date

April 30, 2027

Study Completion Date

April 30, 2028

Conditions
ArthralgiaMenopausePerimenopausal DisorderJoint PainPostmenopausal Disorder
Interventions
DRUG

Menopausal hormone therapy

Apply 17 beta-Estradiol topical gel (1.25-2.5 gms) daily Ingest Micronized Progesterone 200mg daily for 12 days each month

BEHAVIORAL

Exercise training

Exercises would focus on upper and lower body strength generally. It is anticipated that the participants ideally should exercise at least 3 times per week based on the strength training prescription. They could potentially exercise everyday, alternating between upper and lower body strength training. In all, there are up to 1-2 in-person therapy sessions and home sessions at least 3 times per week.

COMBINATION_PRODUCT

Menopausal hormone therapy + exercise training

"1. Apply 17 beta-Estradiol topical gel (1.25-2.5 gms) daily and Ingest Micronized Progesterone 200mg daily for 12 days each month~2. Exercises would focus on upper and lower body strength generally. It is anticipated that patients ideally should exercise at least 3 times per week based on the strength training prescription. They could potentially exercise everyday, alternating between upper and lower body strength training. In all, there are up to 1-2 in-person therapy sessions and home sessions at least 3 times per week."

Trial Locations (1)

Unknown

RECRUITING

National University Hospital, Singapore

All Listed Sponsors
lead

National University Hospital, Singapore

OTHER