A Comparison of NeuroSpan Bridge, NeuraGen Nerve Guide, and Nerve Autograft for Peripheral Nerve Repair

NARecruitingINTERVENTIONAL
Enrollment

80

Participants

Timeline

Start Date

March 21, 2025

Primary Completion Date

December 31, 2027

Study Completion Date

August 31, 2028

Conditions
Peripheral Nerve Injuries
Interventions
DEVICE

NeuroSpan Bridge

"The implant is used to connect peripheral nerve discontinuities. It is designed to be an interface between the nerve and surrounding tissue and to create a conduit for axonal growth across a nerve gap.~The NeuroSpan Bridge is a novel scaffold to support regeneration that mimics the natural bio- architecture, providing multiple channels that are strictly linear so that axonal position is accurately maintained across the full length of the scaffold - over any length - to re-enter the distal nerve stump."

DEVICE

NeuroGen Nerve Guide

The NeuraGen Nerve Guide is a resorbable implant for the repair of 0.5-1.0cm peripheral nerve discontinuities. NeuraGen Nerve Guide provides a protective environment for peripheral nerve repair after injury. It is designed to be an interface between the nerve and surrounding tissue and to create a conduit for axonal growth across a nerve gap. The semi-permeable type 1 collagen membrane allows for controlled resorption, appropriate nutrient diffusion and retention of representative Nerve Growth Factor.

DEVICE

Nerve Autograft

A nerve autograft is a surgical procedure that involves transplanting a segment of a patient's own sensory nerve tissue to repair a damaged peripheral nerve injury measuring 1.1-3.0cm. It is designed to be an interface between the nerve and surrounding tissue and to create a conduit for axonal growth across a nerve gap

Trial Locations (6)

10003

RECRUITING

NYU Langone Orthopedic Center, New York

19104

NOT_YET_RECRUITING

University of Pennsylvania- Penn Presbyterian Medical Center, Philadelphia

21218

RECRUITING

Medstar Union Memorial Hospital- The Curtis National Hand Center, Baltimore

43212

RECRUITING

OSU Wexner Medical Center, Columbus

78258

RECRUITING

The San Antonio Orthopaedic Group (TSAOG Orthopaedics), San Antonio

94158

RECRUITING

UCSF Orthopedic Institute, San Francisco

Sponsors
All Listed Sponsors
collaborator

MCRA

INDUSTRY

lead

Auxilium Biotechnologies

INDUSTRY

NCT06529835 - A Comparison of NeuroSpan Bridge, NeuraGen Nerve Guide, and Nerve Autograft for Peripheral Nerve Repair | Biotech Hunter | Biotech Hunter