NCT06529809View on ClinicalTrials.gov

Accelerated Brachytherapy Forward Chemo Radiation Therapy (ABC-RT) for Locally-advanced Cervical Cancer

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

50

Participants

Timeline

Start Date

February 11, 2025

Primary Completion Date

December 31, 2031

Study Completion Date

December 31, 2031

Conditions
Locally Advanced Cervical Carcinoma
Interventions
RADIATION

Hypofractionated external beam radiation

Central pelvis (19.05 Gy in 15 fractions), nodal basins (40 Gy in 15 fractions), with a simultaneous integrated boost to grossly positive lymph nodes (48 Gy in 15 fractions)

DRUG

Chemotherapy

Concurrent chemotherapy are not dictated by the protocol and will follow standard of care guidelines

RADIATION

Image-guided brachytherapy

HDR boost 7.3 Gy x 6 fractions

Trial Locations (1)

63110

RECRUITING

Washington University School of Medicine, St Louis

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

Washington University School of Medicine

OTHER