N10: A Study of Reduced Chemotherapy and Monoclonal Antibody (mAb)-Based Therapy in Children With Neuroblastoma

DANYELZA is a humanized monoclonal antibody of the IgG1 subclass

Yeast derived recombinant human Sargramostim (GM-CSF)

Cyclophosphamide is an alkylating agent related to nitrogen mustard

Topotecan is a topoisomerase I-inhibitor that is a semisynthetic derivative of camptothecin.

Vincristine is an alkaloid isolated from Vinca rosea Linn (periwinkle).

Doxorubicin is an anthracycline antibiotic

Ifosfamide is a structural analogue of cyclophosphamide

Etoposide for Injection is available as a 20 mg/mL solution in sterile multiple dose vials (5 mL, 25 mL, or 50 mL each).

Carboplatin is available in 50 mg, 150 mg, 450 mg, and 600 mg vials.

Irinotecan hydrochloride trihydrate (CPT-11) is a topoisomerase I inhibitor

Temozolomide is administered intravenously