Prediction of Decompensation and HCC Development in Advanced Chronic Liver Disease

RecruitingOBSERVATIONAL
Enrollment

600

Participants

Timeline

Start Date

September 1, 2024

Primary Completion Date

September 30, 2025

Study Completion Date

September 30, 2027

Conditions
Liver DiseasesHepatocellular CarcinomaHepatocarcinomaAdvanced Chronic Liver Disease
Interventions
OTHER

Standard survillance protocol

Patients will be followed every 6 months. They will undergo at each visit an ultrasound examination including liver stiffness and a routine blood test, including AFP. Other examinations are carried out according to the standard of medical care. Blood, urine and stool tests as well as instrumental diagnostics such as duplex ultrasound, computer tomography, MR-tomography, endoscopies, bone marrow punctures, elastographies, TIPS implantations, operations, etc. will be performed as part of the usual diagnostic clarification.

OTHER

Stratified survillance protocol

"Based on PLEASE and M10LS20 scores, patients will be followed every 3 or 12 months. Low-risk patients will be followed once per year, and high-risk patients every 3 months.~They will undergo at each visit an ultrasound examination including liver stiffness and a routine blood test, including AFP. Other examinations are carried out according to the standard of medical care. Blood, urine and stool tests as well as instrumental diagnostics such as duplex ultrasound, computer tomography, MR-tomography, endoscopies, bone marrow punctures, elastographies, TIPS implantations, operations, etc. will be performed as part of the usual diagnostic clarification."

Trial Locations (1)

48149

RECRUITING

University Hospital Muenster, Münster

All Listed Sponsors
lead

University Hospital Muenster

OTHER