420
Participants
Start Date
February 1, 2025
Primary Completion Date
August 16, 2028
Study Completion Date
August 16, 2028
Intravenous administration of Methylprednisolone
Patients will take intravenous administration of Methylprednisolone (500mg/100ml by IV over 30 minutes per day) for 3 days.
Oral Prednisone
After intravenous administration of Methylprednisolone patients will take by oral Prednisone 1mg/kg per day once a day (with a maximum dose of 90 mg per day for patients weighing \> 90kg) for 1 month, followed with a progressive decrease of 10 mg Prednisone every 15 days until a dose of 10mg per day during 15 days (= stop).
Perfusion of placebo
Patients will take perfusion of placebo (G5%: 100ml over 30 minutes per day) for 3 days.
Oral Prednisone placebo
After the perfusion of placebo, patients will take by oral Prednisone placebo once a day for the same duration as that required if the patient was in the investigational medicinal products group (1 month + progressive decrease).
Assistance Publique - Hôpitaux de Paris
OTHER