Effect of Different Depths of Neuromuscular Blockade on Respiratory Mechanics in Patients With Moderate-severe Acute Respiratory Distress Syndrome

NARecruitingINTERVENTIONAL
Enrollment

20

Participants

Timeline

Start Date

June 28, 2024

Primary Completion Date

May 30, 2025

Study Completion Date

June 30, 2025

Conditions
ARDSLung Protective Ventilation
Interventions
DRUG

cisatracurium

The initial bolus dose of cisatracurium injection is 0.05-0.1mg/kg, followed by a continuous infusion of 1ug/kg/min of cisatracurium, with data on vital signs, respiratory mechanics, TOF response, etc. recorded after a 15-minute wait. The maintenance infusion dose of cisatracurium is then gradually increased in a gradient of 0.5ug/kg/min, with data collection after a 15-minute wait after each increase. If the patient\'s spontaneous breathing completely disappears, the infusion dose of cisatracurium will no longer be increased, and the titration will end.

Trial Locations (1)

Unknown

RECRUITING

Zhongda Hospital, Affiliated to Southeast University, Nanjing

All Listed Sponsors
lead

Southeast University, China

OTHER