Role of Interleukin-13 Pathways on Pain and Itch Sensitivity

A small drop of histamine dihydrochloride (1%, in saline) will be applied to a previously determined area on the volar forearm followed by a prick through the drop.

Approximately 30-35 cowhage spicules will be manually inserted into the subject's skin.

A small drop of BAM8-22 solution will be applied to a previously determined area on the volar forearm followed by a prick through the drop.