52
Participants
Start Date
December 16, 2024
Primary Completion Date
July 23, 2026
Study Completion Date
September 13, 2027
Ivosidenib
Two 250 mg tablets, totaling 500 mg, administered orally once daily, taken continuously throughout treatment duration
Durvalumab (for the first 8, 21-day, cycles)
1500mg intravenous (IV) infusion every 3 weeks, for a maximum of 8 (21-day) cycles
Gemcitabine (for the first 8, 21-day, cycles)
1000 mg/m2 IV infusion on days 1 and 8 of every 21-day cycle, for a maximum of 8 cycles
Cisplatin (for the first 8, 21-day, cycles)
25 mg/m\^2 IV infusion on days 1 and 8 of every 21-day cycle, for a maximum of 8 cycles
Durvalumab (starting from cycle 9)
1500mg intravenous (IV) infusion every 4 weeks, starting from cycle 9. Cycles are 28 days long, starting Cycle 9.
Ivosidenib Recommended Combination Dose (RCD)
RCD administered orally once daily, taken continuously throughout treatment duration
NOT_YET_RECRUITING
Alfred Health, Melbourne
RECRUITING
Seoul National University Hospital, Seoul
RECRUITING
Severance, Seoul
RECRUITING
Seoul St. Mary'S Hospital, Seoul
RECRUITING
H. Valle de Hebron, Barcelona
RECRUITING
Memorial Sloan Kettering Cancer Center, New York
RECRUITING
Charite Universitatsmedizin, Berlin
RECRUITING
Cha Bundang Medical Center, Seongnam
RECRUITING
Seoul National University Bundang Hospital, Seongnam
RECRUITING
Hospital Universitario Gregorio Marañón, Madrid
RECRUITING
H. 12 de Octubre, Madrid
NOT_YET_RECRUITING
Hospital Universitario Fundación Jiménez Díaz, Madrid
NOT_YET_RECRUITING
Gibbs Cancer Center, Spartanburg
NOT_YET_RECRUITING
Medizinische Hochschule Hannover Oe 6810, Hanover
RECRUITING
Institut Bergonie, Bordeaux
NOT_YET_RECRUITING
Moffitt Cancer Center, Tampa
RECRUITING
Chu Montpellier-Hopital Saint-Eloi, Montpellier
RECRUITING
Universitätsklinikum Düsseldorf, Düsseldorf
RECRUITING
Universitären Centrums Für Tumorerkrankungen (Uct) Der J.W. Goethe-Universität Frankfurt, Frankfurt
RECRUITING
Northwestern Medicine, Chicago
NOT_YET_RECRUITING
Universitätsklinikum Ulm, Ulm
RECRUITING
Usc Norris Comprehensive Cancer Center, Los Angeles
RECRUITING
Hôpital Beaujon, Clichy
NOT_YET_RECRUITING
Fred Hutchinson Cancer Center, Seattle
RECRUITING
National Cancer Center Hospital East, Kashiwa
RECRUITING
National Cancer Center Hospital, Chūōku
RECRUITING
Kyoto University Hospital, Kyoto
RECRUITING
Kanagawa Cancer Center, Yokohama
Institut de Recherches Internationales Servier
OTHER