A Study to Evaluate Preventive Treatments for Talquetamab-related Oral Toxicity

PHASE2RecruitingINTERVENTIONAL
Enrollment

130

Participants

Timeline

Start Date

August 26, 2024

Primary Completion Date

April 15, 2026

Study Completion Date

October 18, 2027

Conditions
Relapse Multiple MyelomaRefractory Multiple Myeloma
Interventions
DRUG

Talquetamab

Talquetamab will be administered subcutaneously.

DRUG

Prophylaxis A

Prophylaxis A will be administered orally.

DRUG

Prophylaxis B

Prophylaxis B will be administered orally.

DRUG

Prophylaxis C

Prophylaxis C will be administered orally.

Trial Locations (37)

10029

RECRUITING

Icahn School of Medicine at Mt. Sinai, New York

14642

RECRUITING

University of Rochester Medical Center, Rochester

23298

RECRUITING

Virginia Commonwealth University - Massey Cancer Center, Richmond

27705

RECRUITING

Duke University Medical Center, Durham

28034

RECRUITING

Hosp. Univ. Ramon Y Cajal, Madrid

28041

RECRUITING

Hosp. Univ. 12 de Octubre, Madrid

28223

RECRUITING

Hosp. Quiron Madrid Pozuelo, Pozuelo de Alarcón

30120

RECRUITING

Hosp. Univ. Virgen de La Arrixaca, El Palmar

37007

RECRUITING

Hosp Clinico Univ de Salamanca, Salamanca

44106

RECRUITING

University Hospitals Cleveland Medical Center, Cleveland

80218

RECRUITING

Colorado Blood Cancer Institute, Denver

94143

RECRUITING

University of California San Francisco, San Francisco

98109

RECRUITING

University of Washington, Seattle

06510

RECRUITING

Yale University School Of Medicine, New Haven

70390-140

RECRUITING

Hospitais Integrados da Gavea SA DF Star, Brasília

95070-560

RECRUITING

Fundacao Universidade de Caxias do Sul, Caxias do Sul

81520-060

RECRUITING

Hospital Erasto Gaertner- Liga Paranaense de Combate ao Cancer, Curitiba

41253 190

RECRUITING

Instituto D Or de Pesquisa e Ensino, Salvador

01455 010

RECRUITING

Clinica Medica Sao Germano S/S LTDA, São Paulo

04543-000

RECRUITING

Instituto D Or de Pesquisa e Ensino IDOR, São Paulo

1081 HV

RECRUITING

VUMC Amsterdam, Amsterdam

3318 AT

RECRUITING

Albert Schweitzer Ziekenhuis, Dordrecht

3015 CN

RECRUITING

Erasmus MC, Rotterdam

00918

RECRUITING

Hospital Espanol Auxilio Mutuo Auxilio Mutuo Cancer Center, San Juan

03080

RECRUITING

Seoul National University Hospital, Seoul

06591

RECRUITING

The Catholic University of Korea Seoul St Mary s Hospital, Seoul

135-230

RECRUITING

Samsung Medical Center, Seoul

08916

RECRUITING

Hosp. Univ. Germans Trias I Pujol, Badalona

08036

RECRUITING

Hosp Clinic de Barcelona, Barcelona

BT9 7AB

RECRUITING

Belfast City Hospital, Belfast

CO4 5JL

RECRUITING

Colchester Hospital University NHS, Colchester

BN21 2UD

RECRUITING

Eastbourne District General Hospital, Eastbourne

L7 8YA

RECRUITING

The Clatterbridge Cancer Centre, Liverpool

NW1 2BU

RECRUITING

University College London Hospitals, London

W12 0HS

RECRUITING

Hammersmith Hospital, London

M20 4BX

RECRUITING

The Christie NHS Foundation Trust Christie Hospital, Manchester

NE7 7DN

RECRUITING

Newcastle Freeman Hospital, Newcastle upon Tyne

All Listed Sponsors
lead

Janssen Research & Development, LLC

INDUSTRY