Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain

PHASE3RecruitingINTERVENTIONAL
Enrollment

269

Participants

Timeline

Start Date

December 12, 2024

Primary Completion Date

June 30, 2028

Study Completion Date

June 30, 2028

Conditions
Anatomic Stage IV Breast Cancer AJCC v8Metastatic Breast CarcinomaMetastatic Digestive System CarcinomaMetastatic Lung Non-Small Cell CarcinomaMetastatic Malignant Neoplasm in the BrainMetastatic Malignant Solid NeoplasmMetastatic MelanomaMetastatic Renal Cell CarcinomaStage IV Lung Cancer AJCC v8Stage IV Renal Cell Cancer AJCC v8
Interventions
PROCEDURE

Computed Tomography

Undergo CT

RADIATION

Fractionated Stereotactic Radiation Therapy

Undergo FSRS

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

RADIATION

Stereotactic Radiosurgery

Undergo SRS

Trial Locations (223)

10016

RECRUITING

Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York

10065

RECRUITING

Memorial Sloan Kettering Cancer Center, New York

10461

RECRUITING

Montefiore Medical Center-Einstein Campus, The Bronx

RECRUITING

Montefiore Medical Center-Weiler Hospital, The Bronx

10467

RECRUITING

Montefiore Medical Center - Moses Campus, The Bronx

10604

RECRUITING

Memorial Sloan Kettering Westchester, Harrison

11220

RECRUITING

NYU Langone Hospital - Brooklyn, Brooklyn

11501

RECRUITING

NYU Langone Hospital - Long Island, Mineola

11553

RECRUITING

Memorial Sloan Kettering Nassau, Uniondale

11725

RECRUITING

Memorial Sloan Kettering Commack, Commack

11794

RECRUITING

Stony Brook University Medical Center, Stony Brook

13210

RECRUITING

State University of New York Upstate Medical University, Syracuse

13215

RECRUITING

SUNY Upstate Medical Center-Community Campus, Syracuse

15213

RECRUITING

UPMC-Presbyterian Hospital, Pittsburgh

15232

RECRUITING

UPMC-Shadyside Hospital, Pittsburgh

17201

RECRUITING

Chambersburg Hospital, Chambersburg

17403

RECRUITING

WellSpan Health-York Cancer Center, York

RECRUITING

WellSpan Health-York Hospital, York

18015

RECRUITING

Saint Luke's University Hospital-Bethlehem Campus, Bethlehem

18104

RECRUITING

Saint Luke's Cancer Center - Allentown, Allentown

18512

RECRUITING

Northeast Radiation Oncology Center, Dunmore

18951

RECRUITING

Saint Luke's Hospital - Upper Bucks Campus, Quakertown

19103

RECRUITING

NRG Oncology, Philadelphia

19104

RECRUITING

University of Pennsylvania/Abramson Cancer Center, Philadelphia

19107

RECRUITING

Thomas Jefferson University Hospital, Philadelphia

19114

RECRUITING

Jefferson Torresdale Hospital, Philadelphia

19611

RECRUITING

Reading Hospital, West Reading

20774

RECRUITING

UM Capital Region Medical Center, Largo

21014

RECRUITING

UM Upper Chesapeake Medical Center, Bel Air

21044

RECRUITING

Central Maryland Radiation Oncology in Howard County, Columbia

21061

RECRUITING

UM Baltimore Washington Medical Center/Tate Cancer Center, Glen Burnie

21157

RECRUITING

William E Kahlert Regional Cancer Center/Sinai Hospital, Westminster

21201

RECRUITING

Maryland Proton Treatment Center, Baltimore

RECRUITING

University of Maryland/Greenebaum Cancer Center, Baltimore

21215

RECRUITING

Sinai Hospital of Baltimore, Baltimore

21601

RECRUITING

University of Maryland Shore Medical Center at Easton, Easton

23298

RECRUITING

VCU Massey Comprehensive Cancer Center, Richmond

30060

RECRUITING

Wellstar Kennestone Hospital, Marietta

30106

RECRUITING

WellStar Cobb Hospital, Austell

30308

RECRUITING

Emory University Hospital Midtown, Atlanta

30309

RECRUITING

Piedmont Hospital, Atlanta

30322

RECRUITING

Emory University Hospital/Winship Cancer Institute, Atlanta

33136

RECRUITING

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33146

RECRUITING

UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables

33166

RECRUITING

UM Sylvester Comprehensive Cancer Center at Doral, Doral

33176

RECRUITING

Miami Cancer Institute, Miami

RECRUITING

UM Sylvester Comprehensive Cancer Center at Kendall, Miami

33180

RECRUITING

UM Sylvester Comprehensive Cancer Center at Aventura, Aventura

33324

RECRUITING

UM Sylvester Comprehensive Cancer Center at Plantation, Plantation

33442

RECRUITING

UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach

33486

RECRUITING

Boca Raton Regional Hospital, Boca Raton

33544

RECRUITING

Moffitt Cancer Center at Wesley Chapel, Wesley Chapel

33607

RECRUITING

Moffitt Cancer Center-International Plaza, Tampa

33612

RECRUITING

Moffitt Cancer Center - McKinley Campus, Tampa

RECRUITING

Moffitt Cancer Center, Tampa

37204

RECRUITING

Vanderbilt Breast Center at One Hundred Oaks, Nashville

37232

RECRUITING

Vanderbilt University/Ingram Cancer Center, Nashville

40202

RECRUITING

The James Graham Brown Cancer Center at University of Louisville, Louisville

40245

RECRUITING

UofL Health Medical Center Northeast, Louisville

40536

RECRUITING

University of Kentucky/Markey Cancer Center, Lexington

42303

RECRUITING

Owensboro Health Mitchell Memorial Cancer Center, Owensboro

43015

RECRUITING

Delaware Health Center-Grady Cancer Center, Delaware

RECRUITING

Grady Memorial Hospital, Delaware

43210

RECRUITING

Ohio State University Comprehensive Cancer Center, Columbus

43214

RECRUITING

Riverside Methodist Hospital, Columbus

43215

RECRUITING

Grant Medical Center, Columbus

44060

RECRUITING

UH Seidman Cancer Center at Lake Health Mentor Campus, Mentor

44106

RECRUITING

Case Western Reserve University, Cleveland

44501

ACTIVE_NOT_RECRUITING

Saint Elizabeth Youngstown Hospital, Youngstown

45069

RECRUITING

University of Cincinnati Cancer Center-West Chester, West Chester

45219

RECRUITING

University of Cincinnati Cancer Center-UC Medical Center, Cincinnati

45429

ACTIVE_NOT_RECRUITING

Kettering Medical Center, Kettering

45431

ACTIVE_NOT_RECRUITING

Indu and Raj Soin Medical Center, Beavercreek

46307

RECRUITING

Northwest Cancer Center - Main Campus, Crown Point

RECRUITING

UChicago Medicine Northwest Indiana, Crown Point

46311

RECRUITING

Northwest Oncology LLC, Dyer

46321

RECRUITING

The Community Hospital, Munster

RECRUITING

Women's Diagnostic Center - Munster, Munster

46342

RECRUITING

Northwest Cancer Center - Hobart, Hobart

RECRUITING

Saint Mary Medical Center, Hobart

46383

RECRUITING

Northwest Cancer Center - Valparaiso, Valparaiso

46526

RECRUITING

Goshen Center for Cancer Care, Goshen

48106

RECRUITING

Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor

48109

RECRUITING

University of Michigan Comprehensive Cancer Center, Ann Arbor

48114

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Brighton, Brighton

48154

RECRUITING

Trinity Health Saint Mary Mercy Livonia Hospital, Livonia

48197

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti

48202

RECRUITING

Henry Ford Hospital, Detroit

48601

RECRUITING

MyMichigan Medical Center Saginaw, Saginaw

48764

RECRUITING

MyMichigan Medical Center Tawas, Tawas City

50010

RECRUITING

Mary Greeley Medical Center, Ames

RECRUITING

McFarland Clinic - Ames, Ames

53226

RECRUITING

Medical College of Wisconsin, Milwaukee

53718

RECRUITING

University of Wisconsin Carbone Cancer Center - Eastpark Medical Center, Madison

53792

RECRUITING

University of Wisconsin Carbone Cancer Center - University Hospital, Madison

54401

RECRUITING

Aspirus Regional Cancer Center, Wausau

54409

RECRUITING

Langlade Hospital and Cancer Center, Antigo

54481

RECRUITING

Aspirus Cancer Care - Stevens Point, Stevens Point

54494

RECRUITING

Aspirus Cancer Care - Wisconsin Rapids, Wisconsin Rapids

54501

RECRUITING

Aspirus Cancer Care - James Beck Cancer Center, Rhinelander

54911

RECRUITING

ThedaCare Regional Cancer Center, Appleton

55362

RECRUITING

Monticello Cancer Center, Monticello

56303

RECRUITING

Coborn Cancer Center at Saint Cloud Hospital, Saint Cloud

57104

RECRUITING

Sanford Cancer Center Oncology Clinic, Sioux Falls

58122

RECRUITING

Sanford Broadway Medical Center, Fargo

RECRUITING

Sanford Roger Maris Cancer Center, Fargo

60126

RECRUITING

Elmhurst Memorial Hospital, Elmhurst

60153

RECRUITING

Loyola University Medical Center, Maywood

60451

RECRUITING

UC Comprehensive Cancer Center at Silver Cross, New Lenox

60462

RECRUITING

University of Chicago Medicine-Orland Park, Orland Park

60540

RECRUITING

Edward Hospital/Cancer Center, Naperville

60555

RECRUITING

Northwestern Medicine Cancer Center Warrenville, Warrenville

60611

RECRUITING

Northwestern University, Chicago

60612

RECRUITING

Rush University Medical Center, Chicago

60637

RECRUITING

University of Chicago Comprehensive Cancer Center, Chicago

61801

RECRUITING

Carle Cancer Center, Urbana

61832

RECRUITING

Carle at The Riverfront, Danville

61938

RECRUITING

Carle Physician Group-Mattoon/Charleston, Mattoon

62269

RECRUITING

Cancer Care Center of O'Fallon, O'Fallon

RECRUITING

HSHS Saint Elizabeth's Hospital, O'Fallon

RECRUITING

Memorial Hospital East, Shiloh

62401

RECRUITING

Carle Physician Group-Effingham, Effingham

RECRUITING

Crossroads Cancer Center, Effingham

62526

RECRUITING

Cancer Care Specialists of Illinois - Decatur, Decatur

RECRUITING

Decatur Memorial Hospital, Decatur

62702

RECRUITING

Southern Illinois University School of Medicine, Springfield

RECRUITING

Springfield Clinic, Springfield

62781

RECRUITING

Springfield Memorial Hospital, Springfield

62801

RECRUITING

Centralia Oncology Clinic, Centralia

63110

RECRUITING

Washington University School of Medicine, St Louis

63129

RECRUITING

Siteman Cancer Center-South County, St Louis

63136

RECRUITING

Siteman Cancer Center at Christian Hospital, St Louis

63141

RECRUITING

Siteman Cancer Center at West County Hospital, Creve Coeur

63376

RECRUITING

Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters

63640

RECRUITING

Parkland Health Center - Farmington, Farmington

65804

RECRUITING

Mercy Hospital Springfield, Springfield

66061

RECRUITING

The University of Kansas Cancer Center - Olathe, Olathe

66160

RECRUITING

University of Kansas Cancer Center, Kansas City

66210

RECRUITING

University of Kansas Cancer Center-Overland Park, Overland Park

68118

RECRUITING

Nebraska Medicine-Village Pointe, Omaha

68123

RECRUITING

Nebraska Medicine-Bellevue, Bellevue

68198

RECRUITING

University of Nebraska Medical Center, Omaha

72205

RECRUITING

University of Arkansas for Medical Sciences, Little Rock

73104

RECRUITING

University of Oklahoma Health Sciences Center, Oklahoma City

77030

RECRUITING

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston

RECRUITING

M D Anderson Cancer Center, Houston

RECRUITING

Memorial Hermann Texas Medical Center, Houston

77079

RECRUITING

MD Anderson West Houston, Houston

77384

RECRUITING

MD Anderson in The Woodlands, Conroe

77478

RECRUITING

MD Anderson in Sugar Land, Sugar Land

77573

RECRUITING

MD Anderson League City, League City

78229

RECRUITING

University of Texas Health Science Center at San Antonio, San Antonio

80045

RECRUITING

UCHealth University of Colorado Hospital, Aurora

80524

RECRUITING

Poudre Valley Hospital, Fort Collins

80528

RECRUITING

Cancer Care and Hematology-Fort Collins, Fort Collins

80538

RECRUITING

Medical Center of the Rockies, Loveland

80631

RECRUITING

UCHealth Greeley Hospital, Greeley

80909

RECRUITING

UCHealth Memorial Hospital Central, Colorado Springs

80920

RECRUITING

Memorial Hospital North, Colorado Springs

84112

RECRUITING

Huntsman Cancer Institute/University of Utah, Salt Lake City

85719

RECRUITING

Banner University Medical Center - Tucson, Tucson

RECRUITING

University of Arizona Cancer Center-North Campus, Tucson

87106

RECRUITING

University of New Mexico Cancer Center, Albuquerque

89502

RECRUITING

Renown Regional Medical Center, Reno

90027

RECRUITING

Kaiser Permanente Los Angeles Medical Center, Los Angeles

90503

RECRUITING

City of Hope South Bay, Torrance

90706

RECRUITING

Kaiser Permanente-Bellflower, Bellflower

91010

RECRUITING

City of Hope Comprehensive Cancer Center, Duarte

91030

RECRUITING

City of Hope South Pasadena, South Pasadena

91761

RECRUITING

Kaiser Permanente-Ontario, Ontario

91786

RECRUITING

City of Hope Upland, Upland

92024

RECRUITING

UC San Diego Health System - Encinitas, Encinitas

92093

RECRUITING

UC San Diego Moores Cancer Center, La Jolla

92103

RECRUITING

UC San Diego Medical Center - Hillcrest, San Diego

92612

RECRUITING

UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine

92618

RECRUITING

City of Hope at Irvine Lennar, Irvine

92806

RECRUITING

Kaiser Permanente-Anaheim, Anaheim

92868

RECRUITING

UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange

92882

RECRUITING

City of Hope Corona, Corona

93534

RECRUITING

City of Hope Antelope Valley, Lancaster

94304

RECRUITING

Stanford Cancer Institute Palo Alto, Palo Alto

94558

RECRUITING

Providence Queen of The Valley, Napa

94598

RECRUITING

John Muir Medical Center-Walnut Creek, Walnut Creek

95403

RECRUITING

Providence Medical Foundation - Santa Rosa, Santa Rosa

96701

RECRUITING

Hawaii Cancer Care - Westridge, ‘Aiea

96706

RECRUITING

The Queen's Medical Center - West Oahu, ‘Ewa Beach

96734

RECRUITING

Castle Medical Center, Kailua

96766

RECRUITING

Wilcox Memorial Hospital and Kauai Medical Clinic, Lihue

96813

RECRUITING

Hawaii Cancer Care Inc - Waterfront Plaza, Honolulu

RECRUITING

Queen's Cancer Cenrer - POB I, Honolulu

RECRUITING

Queen's Medical Center, Honolulu

RECRUITING

University of Hawaii Cancer Center, Honolulu

96817

RECRUITING

Queen's Cancer Center - Kuakini, Honolulu

96826

RECRUITING

Kapiolani Medical Center for Women and Children, Honolulu

97015

RECRUITING

Clackamas Radiation Oncology Center, Clackamas

97030

RECRUITING

Legacy Mount Hood Medical Center, Gresham

97062

RECRUITING

Legacy Meridian Park Hospital, Tualatin

97210

RECRUITING

Legacy Good Samaritan Hospital and Medical Center, Portland

97213

RECRUITING

Providence Portland Medical Center, Portland

97225

RECRUITING

Providence Saint Vincent Medical Center, Portland

98055

RECRUITING

Valley Medical Center, Renton

98684

RECRUITING

Legacy Cancer Institute Medical Oncology and Day Treatment, Vancouver

98686

RECRUITING

Legacy Salmon Creek Hospital, Vancouver

06102

RECRUITING

Hartford Hospital, Hartford

06050

RECRUITING

The Hospital of Central Connecticut, New Britain

04102

RECRUITING

MaineHealth Maine Medical Center - Portland, Portland

04073

RECRUITING

MaineHealth Cancer Care Center of York County, Sanford

04074

RECRUITING

MaineHealth Maine Medical Center- Scarborough, Scarborough

07920

RECRUITING

Memorial Sloan Kettering Basking Ridge, Basking Ridge

07039

RECRUITING

Saint Barnabas Medical Center, Livingston

07748

RECRUITING

Memorial Sloan Kettering Monmouth, Middletown

07645

RECRUITING

Memorial Sloan Kettering Bergen, Montvale

08903

RECRUITING

Rutgers Cancer Institute of New Jersey, New Brunswick

07112

RECRUITING

Newark Beth Israel Medical Center, Newark

07652

RECRUITING

The Valley Hospital - Luckow Pavilion, Paramus

07450

RECRUITING

Valley Health System Ridgewood Campus, Ridgewood

08080

RECRUITING

Sidney Kimmel Cancer Center Washington Township, Sewell

08755

RECRUITING

Community Medical Center, Toms River

17033-0850

RECRUITING

Penn State Milton S Hershey Medical Center, Hershey

57117-5134

RECRUITING

Sanford USD Medical Center - Sioux Falls, Sioux Falls

05401

RECRUITING

University of Vermont Medical Center, Burlington

05405

RECRUITING

University of Vermont and State Agricultural College, Burlington

Unknown

SUSPENDED

Pamela Youde Nethersole Eastern Hospital, Chai Wan

Sponsors

Lead Sponsor

All Listed Sponsors
lead

NRG Oncology

OTHER