AK104 and Low-dose Radiation in Recurrent/Metastatic HNSCC After Failure of First-line Systemic Therapy

PHASE2RecruitingINTERVENTIONAL

Enrollment

Participants

Timeline

Start Date

July 3, 2024

Primary Completion Date

July 1, 2026

Study Completion Date

July 1, 2028

Conditions

Head and Neck Squamous Cell Carcinoma

Interventions

DRUG

Cadonilimab

a PD-1/CTLA-4 dual antibody

RADIATION

Low-dose radiotherapy

Low-dose radiation

RADIATION

SBRT

selected leisions to treat with stereotactic radiotherapy

DRUG

Capecitabine

Capecitabine metronomic chemotherapy

Trial Locations (1)

RECRUITING

Fudan University Shanghai Cancer Center, Shanghai

All Listed Sponsors

lead

Fudan University

OTHER