Quatitative MRI of the Spinal Cord in Cervical Myelopathy: Assessment of Microstuctural Damage for Outcome Improvement

NARecruitingINTERVENTIONAL
Enrollment

100

Participants

Timeline

Start Date

April 3, 2024

Primary Completion Date

May 31, 2025

Study Completion Date

May 31, 2025

Conditions
Cervical Myelopathy
Interventions
DIAGNOSTIC_TEST

MRI standard and qMRI

Non-contrast cervical spine MRI including morphological and quantitative MRI sequences on a 3 Tesla scanner. MRI examination includes conventional and experimental sequences

OTHER

MEPs and SSEPs

Neurophysiological examination by motor and somatosensorial evocked potential using transcranial magnetic stimulation and electrical stimulation to the peripheral nerve

OTHER

Neuromotor assessment

Upper and Lower limb assessment: Purdue Pegboard Test (PTT), Box and Block test (BBT), Nine Hole Peg Test (NHPT), gait analysis and 30 seconds sit to stand test (30CST)

PROCEDURE

Anterior cervical discectomy and fusion

If applicable: Anterior cervical discectomy and fusion surgery using PEEK or modern carbon fiber material

Trial Locations (1)

20089

RECRUITING

IRCCS Istituto Clinico Humanitas, Rozzano

Sponsors
All Listed Sponsors
collaborator

Mediolanum Cardio Research

OTHER

lead

Istituto Clinico Humanitas

OTHER

NCT06486038 - Quatitative MRI of the Spinal Cord in Cervical Myelopathy: Assessment of Microstuctural Damage for Outcome Improvement | Biotech Hunter | Biotech Hunter