600
Participants
Start Date
June 3, 2024
Primary Completion Date
December 31, 2026
Study Completion Date
December 31, 2028
Navtemadlin
Navtemadlin is an investigational MDM2 inhibitor
Navtemadlin placebo
Navtemadlin placebo
Ruxolitinib
Ruxolitinib is a janus kinase 1/2 inhibitor
RECRUITING
Medical University Vienna, Vienna
RECRUITING
Hospital Ottakring, Department of Internal Medicine I, Vienna
RECRUITING
Antwerp Hospital Network (ZNA) Cadix, Antwerp
RECRUITING
University Hospitals Leuven, Campus Gasthuisberg, Leuven
RECRUITING
University Hospital Center Sart-Tilman, Liège
RECRUITING
Ordensklinikum Linz GmbH Elisabethinen Hospital, Department of Internal Medicine I - Hemato-Oncology, Linz
RECRUITING
Kepler University Hospital GmbH, Med Campus 3, University Clinic for Hematology and Internal Oncology, Linz
RECRUITING
Szabolcs-Szatmar-Bereg County Teaching Hospital, Nyíregyháza
RECRUITING
JSC Vian, Kutaisi
RECRUITING
UCL Mont-Godinne University Hospitals, Yvoir
RECRUITING
Royal Perth Hospital, Perth
RECRUITING
Sir Charles Gairdner Hospital, Nedlands
RECRUITING
Medical University Innsbruck, Department of Internal Medicine V (Hematology and Oncology), Innsbruck
RECRUITING
Royal Hobart Hospital (RHH), Hobart
RECRUITING
Clinical Hospital Center Bezanijska Kosa, Belgrade
RECRUITING
University Hospital Graz, Department of Internal Medicine, Graz
RECRUITING
Regional Hospital Hochsteiermark - Leoben, Department of Internal Medicine, Department of Hematology and Oncology, Leoben
RECRUITING
General Hospital Delta, Roeselare
RECRUITING
Clinical Hospital Dubrava, Zagreb
RECRUITING
Clinical Hospital Merkur, Zagreb
RECRUITING
Solmed Clinic, Zagreb
RECRUITING
University Hospital Centre Zagreb, Zagreb
WITHDRAWN
Caceres Hospital Complex - San Pedro de Alcantara General Hospital, Cáceres
RECRUITING
City of Health and Science of Turin, Turin
RECRUITING
Montefiore Einstein Comprehensive Cancer Center, The Bronx
RECRUITING
University Clinical Center of Serbia, Belgrade
RECRUITING
Northwell Health, R.J. Zuckerberg Cancer Center, Lake Success
RECRUITING
Brookdale University Hospital and Medical Center, Brooklyn
RECRUITING
Institute of Hematology and Blood Transfusion, Prague
RECRUITING
Cayuga Cancer Center, Ithaca
RECRUITING
West Penn Hospital, Pittsburgh
RECRUITING
Abramson Cancer Center of the University of Pennsylvania, Philadelphia
RECRUITING
Medical Oncology Hematology Consultants, PA, Newark
RECRUITING
MedStar Georgetown University Hospital, Lombardi Comprehensive Cancer Center, Washington D.C.
RECRUITING
Maggiore Polyclinic Hospital, Foundation IRCCS Ca' Granda, Milan
RECRUITING
University Hospital Hamburg-Eppendorf, Hamburg
RECRUITING
The Center for Cancer and Blood Disorders, Bethesda
RECRUITING
University Hospital of Split, Split
RECRUITING
Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore
RECRUITING
General Hospital of Sibenik-Knin County, Šibenik
RECRUITING
Virginia Cancer Institute, Richmond
RECRUITING
VCU Medical Center, Richmond
RECRUITING
Virginia Oncology Associates - Virginia Beach, Virginia Beach
RECRUITING
University Hospital Schleswig-Holstein, Kiel
RECRUITING
University General Hospital of Patras, Pátrai
RECRUITING
Atrium Health Wake Forest Baptist, Winston-Salem
RECRUITING
Duke University Medical Center, Durham
RECRUITING
Regional Medical Oncology Center, Wilson
RECRUITING
University Hospital 12 de Octubre, Madrid
RECRUITING
University Hospital Ramon y Cajal, Madrid
RECRUITING
"University Hospital Maggiore della Carita of Novara", Novara
RECRUITING
Atrium Health Levine Cancer Institute, Charlotte
RECRUITING
University Hospital Virgen de la Victoria, Málaga
RECRUITING
Nimes University Hospital Center, Department of Clinical Hematology and Medical Oncology, Nîmes
RECRUITING
Mayo Clinic - Jacksonville, Jacksonville
RECRUITING
AdventHealth Cancer Institute, Orlando
RECRUITING
University of Miami, Miami
RECRUITING
Moffitt Cancer Center, Tampa
RECRUITING
Gran Canaria Dr Negrin University Hospital, Las Palmas de Gran Canaria
RECRUITING
UAB Hospital, Birmingham
RECRUITING
Tours Regional University Hospital Center, Tours
RECRUITING
University Clinical Hospital of Salamanca, Salamanca
RECRUITING
Tennessee Oncology, Nashville
RECRUITING
Vanderbilt University Medical Center, Nashville
RECRUITING
Tennessee Oncology, Chattanooga
RECRUITING
Polyclinic S. Orsola-Malpighi, Bologna
RECRUITING
Norton Cancer Institute, Louisville
RECRUITING
Marien Hospital Duesseldorf GmbH, Düsseldorf
RECRUITING
Kyungpook National University Hospital, Daegu
RECRUITING
Keimyung University - Dongsan Medical Center, Daegu
RECRUITING
Nantes University Hospital Center - Hotel Dieu Hospital, Nantes
RECRUITING
Cleveland Clinic Cancer Center at Fairview Hospital, Cleveland
RECRUITING
Hillcrest Hospital - Cleveland Clinic, Mayfield Heights
RECRUITING
Independence Family Health Center - Cleveland Clinic, Independence
RECRUITING
Cleveland Clinic, Cleveland
RECRUITING
Gabrail Cancer Center, Canton
RECRUITING
University of Cincinnati Medical Center, Cincinnati
RECRUITING
University Clinical Hospital of Valencia, Valencia
RECRUITING
University and Polytechnic Hospital La Fe, Valencia
RECRUITING
"Institute of Romagna for Cancer Research Dino Amadori - IRCCS IRST", Forlì
RECRUITING
Inje University Busan Paik Hospital, Busan
RECRUITING
University of Michigan Hospital, Ann Arbor
RECRUITING
Henry Ford Cancer Institute - Brigitte Harris Cancer Pavilion, Detroit
RECRUITING
Pusan National University Hospital, Busan
RECRUITING
Quironsalud Zaragoza Hospital, Zaragoza
RECRUITING
Careggi University Hospital, Florence
RECRUITING
Mission Cancer + Blood, Des Moines
RECRUITING
Sheboygan Cancer & Blood Specialists, Sheboygan
RECRUITING
Amiens Picardie University Hospital - South, Amiens
RECRUITING
Lille Regional University Hospital Center, Lille
RECRUITING
Marche University Hospital, Ancona
RECRUITING
Local Health Company of Pesaro and Urbino, Pesaro
RECRUITING
University of Kansas Cancer Center - Westwood, Westwood
RECRUITING
Strasbourg Europe Institut of Cancerology, Strasbourg
RECRUITING
Nebraska Hematology - Oncology, P.C., Lincoln
RECRUITING
University Hospital Heidelberg, Heidelberg
RECRUITING
South Lyon Hospital Center, Lyon
RECRUITING
Robert-Bosch-Hospital, Stuttgart
RECRUITING
Mary Bird Perkins Cancer Center, Baton Rouge
RECRUITING
Staufer Schwaebisch Gmuend Hospital, Mutlangen
RECRUITING
Saint-Louis Hospital, Department of Adult Hematology, Paris
RECRUITING
UT - SouthWestern, Dallas
RECRUITING
U.T. MD Anderson Cancer Center, Houston
RECRUITING
The University of Texas Health Science Center at San Antonio, San Antonio
RECRUITING
University Hospital Freiburg, Freiburg im Breisgau
RECRUITING
Rocky Mountain Cancer Centers - Aurora, Aurora
RECRUITING
Hospital Rechts der Isar, Munich
RECRUITING
University of Utah, Huntsman Cancer Institute, Salt Lake City
RECRUITING
Mayo Clinic - Phoenix, Phoenix
RECRUITING
Banner MD Anderson Cancer Center, Gilbert
RECRUITING
Mohtaseb Cancer Center and Blood Disorders, Henderson
RECRUITING
University Hospital Ulm, Ulm
RECRUITING
UCLA Hematology/Oncology Clinic - Los Angeles, Los Angeles
RECRUITING
Hospital Nuernberg, Campus North, Nuremberg
RECRUITING
The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance
RECRUITING
UC San Diego Moores Cancer Center, La Jolla
RECRUITING
Scripps Health, Prebys Cancer Center, San Diego
RECRUITING
Willamette Valley Cancer Institute and Research Center, Eugene
RECRUITING
Fred Hutchinson Cancer Centre, Seattle
RECRUITING
Northwest Medical Specialties, PLLC - Tacoma, Tacoma
RECRUITING
"Prof. Dr. Ion Chiricuta Institute of Oncology, Hematology Department", Cluj-Napoca
RECRUITING
Bihor County Emergency Clinical Hospital, Department of Hematology, Oradea
RECRUITING
Onco Card Srl, Brasov
RECRUITING
Targu Mures County Emergency Clinical Hospital, Internal Medicine Department I, Hematology Unit, Târgu Mureş
RECRUITING
Dana Farber Cancer Institute, Boston
RECRUITING
Hackensack University Medical Center, Hackensack
RECRUITING
ICAHN School of Medicine at Mount Sinai, New York
RECRUITING
Medical University of South Carolina (MUSC), Charleston
RECRUITING
Royal Adelaide Hospital, Adelaide
RECRUITING
Monash Medical Center Clayton, Clayton
RECRUITING
Townsville University Hospital, Douglas
RECRUITING
Gosford Hospital, Gosford
RECRUITING
St George Hospital, Kogarah
RECRUITING
The Royal Melbourne Hospital - Peter MacCallum Cancer Center, Melbourne
RECRUITING
The Alfred Hospital, Melbourne
RECRUITING
Calvary Mater Newcastle Hospital, Waratah
RECRUITING
Clinical Hospital Centre Rijeka, Rijeka
RECRUITING
University Hospital Brno, Clinic of Internal Medicine - Hematology and Oncology, Brno
RECRUITING
University Hospital Hradec Kralove, Hradec Králové
RECRUITING
University Hospital Ostrava, Ostrava
RECRUITING
University Hospital Kralovske Vinohrady, Prague
RECRUITING
Angers University Hospital Center, Angers
RECRUITING
Leon Berard Center, Lyon
RECRUITING
Bordeaux University Hospital, Pessac
RECRUITING
University Hospital Center of Poitiers, Poitiers
RECRUITING
University Hospital of Toulouse, IUCT-Oncopole, Toulouse
RECRUITING
Hannover Medical School, Hanover
RECRUITING
University General Hospital of Ioannina, Ioannina
RECRUITING
Fejer County St. Gyorgy University Teaching Hospital, Székesfehérvár
RECRUITING
National Hospital SS. Antonio e Biagio e Cesare Arrigo, Alessandria
RECRUITING
ASST Spedali Civili Brescia, Brescia
RECRUITING
"University Hospital G.Rodolico - San Marco", Catania
RECRUITING
European Institute of Oncology (IEO), IRCCS, Milan
RECRUITING
University Hospital San Luigi Gonzaga, Orbassano
RECRUITING
"University Polyclinic Hospital Paolo Giaccone Palermo", Palermo
RECRUITING
Polyclinic San Matteo, IRCCS, Pavia
RECRUITING
Hospital Arcispedale S. Maria Nuova of Reggio Emilia, Reggio Emilia
RECRUITING
Hospital S. Eugenio- Rome 2 ASL, Rome
RECRUITING
ASST Sette Laghi Hospital, Varese
RECRUITING
"InterHem General Partnership", Bialystok
RECRUITING
University Teaching Centre, Hematology and Transplantology Clinic, Gdansk
RECRUITING
Independent Public Healthcare Facility University Hospital in Krakow, Krakow
RECRUITING
Oncology Center of Warmia and Mazury in Olsztyn, Olsztyn
RECRUITING
Dr Alfred Sokolowski Specialty Hospital, Wałbrzych
RECRUITING
Jan Mikulicz-Radecki Teaching Hospital in Wroclaw, Wroclaw
RECRUITING
Braga Hospital, Braga
RECRUITING
Vila Nova de Gaia Central Hospital, Vila Nova de Gaia
RECRUITING
Clinical Center of Vojvodina, Novi Sad
RECRUITING
Catalan Institute of Oncology, Hospital Duran i Reynals, Barcelona
RECRUITING
Archet 1 and 2 hospital, Nice
RECRUITING
JSC German Hospital, Tbilisi
RECRUITING
LEPL The First University Clinic of Tbilisi State Medical University, Tbilisi
RECRUITING
Tbilisi State Medical University and Ingorokva High Medical Technology University Clinic LLC, Tbilisi
RECRUITING
JSC K. Eristavi National Center of Experimental and Clinical Surgery, Tbilisi
RECRUITING
Caucasus Medical Centre LLC, Tbilisi
RECRUITING
University Hospital Halle (Saale), Halle
RECRUITING
University Hospital Jena, Jena
RECRUITING
MVZ Mitte Am Johannisplatz, Leipzig
RECRUITING
General Hospital of Athens Laikon, Athens
RECRUITING
"University General Hospital Attikon", Athens
RECRUITING
"General Hospital of Thessaloniki G. Papanikolaou", Thessaloniki
RECRUITING
Semmelweis University, Budapest
RECRUITING
Tolna County Hospital, Szekszárd
RECRUITING
Nicolaus Copernicus Provincial Multispecialty Oncology and Traumatology Center, Lodz
RECRUITING
Jedrzej Sniadecki Specialist Hospital in Nowy Sacz, Nowy Sącz
RECRUITING
AIDPORT, Poznan
RECRUITING
Dom Lekarski Medical Center Outlet Park, Szczecin
RECRUITING
Janusz Korczak Provincial Specialist Hospital, Słupsk
RECRUITING
Clinical Best Solutions LLC, Limited Partnership, Warsaw
RECRUITING
Hospital Center of Baixo Vouga -Aveiro Unit - Hospital Infante D. Pedro, Aveiro
RECRUITING
Central Hospital of Western Lisbon, Lisbon
RECRUITING
Centro Hospitalar Lisboa Norte (CHLN) EPE - Hospital de Santa Maria, Lisbon
RECRUITING
Colentina Clinical Hospital, Department of Hematology, Bucharest
RECRUITING
University Clinical Center Kragujevac, Kragujevac
RECRUITING
Seoul National University Hospital, Seoul
RECRUITING
Severance Hospital, Yonsei University Health System, Seoul
RECRUITING
Soon Chun Hyang University Hospital Seoul, Seoul
RECRUITING
Asan Medical Center, Seoul
RECRUITING
The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul
RECRUITING
University Hospital Germans Trias i Pujol, Badalona
RECRUITING
University Hospital Vall d'Hebron, Barcelona
RECRUITING
Birmingham Heartlands Hospital, Birmingham
RECRUITING
Lincoln County Hospital, Boston
RECRUITING
Pilgrim Hospital, Boston
RECRUITING
Addenbrooke's Hospital, Cambridge
RECRUITING
University Hospital of Wales, Cardiff
RECRUITING
Western General Hospital, Lothian Health Board, Edinburgh
RECRUITING
Gloucestershire Royal Hospital, Gloucester
RECRUITING
Harrogate District Hospital, Harrogate
RECRUITING
Leicester Royal Infirmary, Leicester
RECRUITING
The Clatterbridge Cancer Center NHS Foundation Trust, Liverpool
RECRUITING
University College Hospital, London
RECRUITING
Guy's Hospital, London
RECRUITING
Genesis Care, Oxford, Oxford
RECRUITING
Genesis Care, Windsor, Windsor
Lead Sponsor
Kartos Therapeutics, Inc.
INDUSTRY