20
Participants
Start Date
September 30, 2024
Primary Completion Date
June 30, 2026
Study Completion Date
July 31, 2026
Low-intensity resistance exercise training
The intervention protocol will consist of 60 minutes of low-intensity resistance exercise training 3x/week for 6 weeks.
High-Dose Remote ischemic conditioning (RIC)
Treatment dose of RIC- the RIC cuff will be inflated to 20 mmHg over the participant's systolic blood pressure. The treatment dose of RIC will be applied in 4 sets of cycles with inflating the cuff and leaving it pumped for 5 minutes then deflating the cuff for an off period of 5 minutes. Total treatment time will be 35 minutes.
Low-Dose Remote ischemic conditioning (RIC)
This dose will be the control for the study. Low-dose RIC- the RIC cuff will be inflated to 10 mmHg below the participant's diastolic blood pressure. The low-dose RIC will be applied in 4 sets of cycles with inflating the cuff and leaving it pumped for 5 minutes then deflating the cuff for an off period of 5 minutes. Total treatment time will be 35 minutes.
Duke University, Durham
Lead Sponsor
National Institutes of Health (NIH)
NIH
Duke University
OTHER